Výsledky vyhledávání - "Jules L Griffin"

Akademický článek

Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.

Autor: Ross A Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J Ragan, James A West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C Kienesberger, Ryszard T Smolenski, Hillary K Siddall, John L Offer, Mihaela M Mocanu, Derek M Yelon, Jason R B Dyck, Jules L Griffin, Andrey Y Abramov, Alex P Gould, Timothy J Mohun

Publikováno v: PLoS Biology, Vol 11, Iss 9, p e1001666 (2013)

Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, wh

Externí odkaz: https://doaj.org/article/c94bc252bb4048fdb56691e64de2627d

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IonFlow: a galaxy tool for the analysis of ionomics data sets

Autor: Robert C. Glen, Jules L. Griffin, Jacopo Iacovacci, W. Lin

Publikováno v: Metabolomics

Introduction Inductively coupled plasma mass spectrometry (ICP-MS) experiments generate complex multi-dimensional data sets that require specialist data analysis tools. Objective Here we describe tools to facilitate analysis of the ionome composed of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33fcc63f5e0d826505debde213918cb
https://www.repository.cam.ac.uk/handle/1810/329853

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An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease

Autor: David C. Rubinsztein, Jules L. Griffin, Benjamin R. Underwood, Zeyn W. Green-Thompson, Peter J. Pugh, Roger A. Barker, P Simon Jones, Stanley E. Lazic, Sarah L Mason, James B. Rowe

Publikováno v: Journal of Neurology

Preclinical data have shown that rilmenidine can regulate autophagy in models of Huntington’s disease (HD), providing a potential route to alter the disease course in patients. Consequently, a 2-year open-label study examining the tolerability and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c8b950ff56b26b8946256f00707f96
http://europepmc.org/articles/PMC5688221

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Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers

Autor: Lucy, Yang, Joseph, Cheriyan, David D, Gutterman, Ruth J, Mayer, Zsuzsanna, Ament, Jules L, Griffin, Aili L, Lazaar, David E, Newby, Ruth, Tal-Singer, Ian B, Wilkinson

Publikováno v: Chest

Background Smoking and COPD are risk factors for cardiovascular disease, and the pathogenesis may involve endothelial dysfunction. We tested the hypothesis that endothelium-derived epoxyeicosatrienoic acid (EET)-mediated endothelial function is impai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::057e7d0cabc13f538b80989266ad2f46
https://pubmed.ncbi.nlm.nih.gov/27884766

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S-Adenosyl Methionine Synthesis Impacts Maintenance of Acute Myeloid Leukemia Cells with Regulation of Transcriptional Elongation

Autor: Rita Romano Adao, Ana Filipa Domingues, Cecilia Castro, Antonio Curti, Jules L. Griffin, Cristina Pina, Alice V Taylor

Publikováno v: Blood. 132:2605-2605

Epigenetic dysregulation is at the heart of Acute Myeloid Leukemia (AML), and its mechanistic understanding holds promise in improving AML dismal prognosis. Modification of chromatin accessibility through post-translational modification of histones a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5c314a0c300a279692c46d32477cf47
https://doi.org/10.1182/blood-2018-99-115004

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TL1A Both Promotes and Protects from Renal Inflammation and Injury

Autor: Wang Min, Eleanor M. Bolton, Edward Chung Yern Wang, Jordan S. Pober, Rafia S. Al-Lamki, John Bradley, Jules L. Griffin, Paul Moore, Jun Wang, Aviva M. Tolkovsky, Sathia Thiru, J. Andrew Bradley

Publikováno v: Journal of the American Society of Nephrology. 19:953-960

Death receptor 3 (DR3), a member of the TNF receptor (TNFR) superfamily, is induced in human renal tubular epithelial cells (TEC) in response to injury. This study examined the expression and actions of TL1A, the principal ligand for DR3. In histolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746bf1281e46511391f1f565362e1559
https://doi.org/10.1681/asn.2007060706

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