Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jules Hernández-Sánchez"'
Autor:
Taufiek K. Rajab, Jason M. Ali, Jules Hernández-Sánchez, Jennifer Mackie, Vincenzo Grimaudo, Silvia Sinichino, Christine Mills, Bushra Rana, John Dunning, Yasir Abu-Omar
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 15, Iss 1, Pp 1-6 (2020)
Abstract Background Approximately 250,000 heart valve operations are performed annually worldwide. An intensive research and development effort has led to progressively more advanced heart valve prostheses. The Carpentier-Edwards Perimount Magna Ease
Externí odkaz:
https://doaj.org/article/777ee10f0237454b81ba24d3b25f07e1
Autor:
Jules Hernández-Sánchez, Louise Harlow, Colin Church, Sean Gaine, Emily Knightbridge, Kate Bunclark, Dee Gor, Alun Bedding, Nicholas Morrell, Paul Corris, Mark Toshner
Publikováno v:
Pulmonary Circulation, Vol 8 (2017)
Our aim is to assess the safety and potential efficacy of a novel treatment paradigm in pulmonary arterial hypertension (PAH), immunomodulation by blocking interleukin-6 (IL6) signaling with the IL6 receptor antagonist, tocilizumab. Inflammation and
Externí odkaz:
https://doaj.org/article/2ade388d719b431ea6ac340587ccef6f
Autor:
Jun‐ichi Nishimura, Antoine Soubret, Noriko Arase, Simon Buatois, Masaki Hotta, Jean‐Eric Charoin, Yoshikazu Ito, Sasha Sreckovic, Hiroyuki Takamori, Christoph Bucher, Yasutaka Ueda, Jules Hernández‐Sánchez, Keisuke Gotanda, Gregor Jordan, Kenji Shinomiya, Julia Ramos, Jin Seok Kim, Jens Panse, Régis Peffault de Latour, Alexander Röth, Eiichi Morii, Hubert Schrezenmeier, Yoshitaka Isaka, Simona Sica, Yuzuru Kanakura, Sung‐Soo Yoon, Taroh Kinoshita, Ido Paz‐Priel, Alexandre Sostelly
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:904-915
Drug–target–drug complexes (DTDCs) are phenomena newly observed in patients who switch from the complement component 5 (C5) inhibitor eculizumab to crovalimab, a novel, anti-C5 antibody in development for paroxysmal nocturnal hemoglobinuria (PNH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f352fecae69e660b9f1196b2bb4809cc
https://doi.org/10.1002/cpt.2851
https://doi.org/10.1002/cpt.2851
Autor:
Charaka M. Hadinnapola, Mark Southwood, Jules Hernández – Sánchez, Katherine Bunclark, Michael Newnham, Emilia M. Swietlik, John Cannon, Stephen D. Preston, Karen Sheares, Dolores Taboada, Nicholas Screaton, David P. Jenkins, Nicholas W. Morrell, Mark Toshner, Joanna Pepke-Zaba
INTRODUCTION: Chronic thromboembolic pulmonary hypertension (CTEPH) is an underdiagnosed disease of uncertain etiology. Altered endothelial homeostasis, defective angiogenesis and inflammation are implicated. Angiopoietin 2 (Ang2) impairs acute throm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d444e0ebaf5070faa555ac5414852c
https://www.repository.cam.ac.uk/handle/1810/344392
https://www.repository.cam.ac.uk/handle/1810/344392
Autor:
Jules Hernández-Sánchez, David G. Kiely, J. Simon R. Gibbs, Joanna Pepke-Zaba, Christopher J. Rhodes, Brian Y.H. Lam, Luke Howard, Richard C. Trembath, Tae-Hwi Schwantes-An, Mark Toshner, John G Coghlan, Paul A. Corris, Amit Arora, Katie A. Lutz, Emily Knightbridge, Colin Church, Stefan Gräf, James Liley, Ken Batai, Marc Humbert, Ankit A. Desai, Louise Harlow, S. John Wort, Sean Gaine, Martin R. Wilkins, William C. Nichols, Rowena Jones, Sofia S Villar Moreschi, Jason H. Karnes, Rick A. Kittles, Lars Harbaum, Dee Gor, Florent Soubrier, Nicholas W. Morrell, Jay Suntharalingam, Michael W. Pauciulo
Publikováno v:
2022, ' Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension ', The European respiratory journal, vol. 59, no. 3, 2002463 . https://doi.org/10.1183/13993003.02463-2020
BackgroundInflammation and dysregulated immunity are important in the development of pulmonary arterial hypertension (PAH). Compelling preclinical data supports the therapeutic blockade of interleukin-6 (IL-6) signalling.MethodsWe conducted a phase 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1669f2f7075fc94c5d8cdd8d56ad4951
https://kclpure.kcl.ac.uk/ws/files/170413390/Mendelian_randomisation_and_experimental_TOSHNER_Published_online_10_Mar_22_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/170413390/Mendelian_randomisation_and_experimental_TOSHNER_Published_online_10_Mar_22_GOLD_VoR_CC_BY_.pdf
Autor:
Princy N Kumar, Jules Hernández-Sánchez, Sandra Nagel, Yuning Feng, Fang Cai, Joseph Rabin, Caryn G Morse, Nandita R Nadig, Obaid Ashraf, Deepa B Gotur, Grace A McComsey, Khalid Gafoor, Patrick Perin, Sarah C Thornton, William Stubbings, Celia J F Lin, Larry Tsai
Publikováno v:
Open Forum Infectious Diseases
Background Tocilizumab, an interleukin 6 receptor (IL-6R) antagonist monoclonal antibody, has shown efficacy in patients with coronavirus disease 2019 (COVID-19) pneumonia, but the optimal dose is unknown. Methods Patients hospitalized for moderate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d52405cc4d5aa1355dfd51a3c1caee
http://europepmc.org/articles/PMC8690270
http://europepmc.org/articles/PMC8690270
Autor:
Leonid Gibiansky, Jules Hernández-Sánchez, Sebastien Jolivet, Annabelle Lemenuel-Diot, Rajinder Bhardwaj, Stefan Sturm, Timothy Knab, Patanjali Ravva, Eric Burroughs Jordie, Elke Zwanziger, Clare Nasmyth-Miller
Publikováno v:
British journal of clinical pharmacologyREFERENCES. 88(3)
AIMS To optimise the dosing regimen of oseltamivir for immunocompromised (IC) paediatric patients (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681c66ce8ab1eaba072d991d0ea9703f
https://pubmed.ncbi.nlm.nih.gov/34449090
https://pubmed.ncbi.nlm.nih.gov/34449090
Autor:
Liam Ring, Hannah Povey, Yasir Abu-Omar, Shakil Farid, Narain Moorjani, Joanne Frances Irons, Ayyaz Ali, Andrew Ladwiniec, Jules Hernández-Sánchez, E. Caruana
Publikováno v:
Heart, Lung and Circulation. 28:314-319
Background To compare early outcomes of mitral valve repair versus replacement in elderly patients with degenerative mitral valve disease. Methods A retrospective review of prospectively collected clinical data of patients over 75 years of age, who u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7dab8758830ab7af5ce3077354246a0
https://doi.org/10.1016/j.hlc.2017.10.027
https://doi.org/10.1016/j.hlc.2017.10.027
Autor:
Jules Hernández-Sánchez, Jason M. Ali, John Dunning, Silvia Sinichino, Yasir Abu-Omar, Bushra S. Rana, Christine Mills, Taufiek Konrad Rajab, Vincenzo Grimaudo, Jennifer Mackie
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 15, Iss 1, Pp 1-6 (2020)
Journal of Cardiothoracic Surgery
Journal of Cardiothoracic Surgery
Background Approximately 250,000 heart valve operations are performed annually worldwide. An intensive research and development effort has led to progressively more advanced heart valve prostheses. The Carpentier-Edwards Perimount Magna Ease (CEPME)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74204d4bc94e1a5321deaa4d288a124
https://doi.org/10.1186/s13019-020-01248-2
https://doi.org/10.1186/s13019-020-01248-2
Autor:
Mike Davies, William R. Davies, Bushra S. Rana, Jules Hernández-Sánchez, Stephen P. Hoole, Patrick A. Calvert, Leonard M. Shapiro, Duncan C. McNab
Publikováno v:
Canadian Journal of Cardiology. 33:1708-1715
Previous studies have shown a higher prevalence of patent foramen ovale (PFO) in patients with obstructive sleep apnea syndrome (OSAS). Right to left shunting through a PFO may be encouraged by the respiratory physiology of OSAS, contributing to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c853205d6d9605fef8ff7e1c9f83a9bf
https://doi.org/10.1016/j.cjca.2017.09.005
https://doi.org/10.1016/j.cjca.2017.09.005