Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Jules Brodeur"'
Publikováno v:
Journal of Applied Toxicology. 32:564-580
Physiologically based pharmacokinetic modeling and occupational exposure assessment studies often use minute ventilation rates (VE), alveolar ventilation rates (VA) and cardiac outputs (Q) that are not reflective of the physiological variations encou
Publikováno v:
Inhalation Toxicology. 23:74-94
The methodology developed in our previous studies ( Brochu et al. 2006a-c ) for the determination of physiological daily inhalation rates was improved by integrating into the calculation process, both nighttime and daytime respiratory parameters, nam
Publikováno v:
Human and Ecological Risk Assessment: An International Journal. 12:702-735
The distribution of physiological daily inhalation rates for pregnant and lactating females aged 11 to 55 years was determined according to total daily energy expenditures, energy costs for growth, pregnancy and lactation (maternal milk-energy synthe
Publikováno v:
AIHA Journal. 64:17-23
This study compared two toxicokinetic approaches for determining correction factors to be applied to occupational exposure limits (ELs) for unusual exposure scenarios: a classic one-compartment toxicokinetic approach and the physiologically based tox
Autor:
Jules Brodeur, Robert Tardif, Ginette Truchon, François Lemay, A. Vyskocil, Guy Perrault, Daniel Drolet
Publikováno v:
AIHAJ. 62:584-594
Research activities sought development of a method to adjust exposure limits for 694 substances for unusual work schedules. A consensus was established on the basic toxicological principle for adjustment; criteria for adjustment were selected by a pa
Publikováno v:
Toxicology and Applied Pharmacology. 144:120-134
The objective of the present study was to develop a physiologically based pharmacokinetic (PBPK) model for a ternary mixture of alkyl benzenes [toluene (TOL), m-xylene (XYL), and ethylbenzene (EBZ)] in rats and humans. The approach involved the devel
Publikováno v:
Toxicology and Applied Pharmacology. 120:266-273
The present study was undertaken to investigate the mechanism of toxicokinetic interaction between toluene (TOL) and m-xylene (XYL) in vivo in the male Sprague-Dawley rat by physiologically based toxicokinetic (PBTK) modeling. First, the metabolic co
Publikováno v:
International Archives of Occupational and Environmental Health. 64:569-580
The present study was undertaken to investigate the influence of different exposure scenarios on the elimination of toluene and m-xylene in alveolar air and other biological fluids in human volunteers. The study was also aimed at establishing the eff
Publikováno v:
Journal of applied toxicology : JAT. 32(8)
Physiologically based pharmacokinetic modeling and occupational exposure assessment studies often use minute ventilation rates (VE), alveolar ventilation rates (VA) and cardiac outputs (Q) that are not reflective of the physiological variations encou
Publikováno v:
Toxicology and Industrial Health. 8:37-52
This review is a critical survey and evaluation of recent literature on solvent interactions for the assessment of health risk. It addresses the implications of multiple solvent exposures 1) by examining the influence of solvent-solvent and ethanol-s