Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jules A. Westbrook"'
Publikováno v:
Cancer Informatics, Vol 18 (2019)
Metastasis to bone occurs in over 70% of patients with advanced breast cancer resulting in skeletal complications, including pathological fractures, hypercalcaemia, and bone pain. Significant advances have been made in the treatment of bone metastase
Externí odkaz:
https://doaj.org/article/eca9c7ae991e4ca7b7c18f211310ce9b
Publikováno v:
Cancer Informatics, Vol 18 (2019)
Metastasis to bone occurs in over 70% of patients with advanced breast cancer resulting in skeletal complications, including pathological fractures, hypercalcaemia, and bone pain. Significant advances have been made in the treatment of bone metastase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8929584daaa89c009331af647d5da39
https://doaj.org/article/eca9c7ae991e4ca7b7c18f211310ce9b
https://doaj.org/article/eca9c7ae991e4ca7b7c18f211310ce9b
Publikováno v:
PROTEOMICS - Clinical Applications. 9:295-300
Isobaric tags for relative and absolute quantitation (iTRAQ), Tandem Mass Tags (TMT) and related chemical tag reagents provide analytical platforms for quantitative proteomics applied to clinical samples. In this Viewpoint article, applications for d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a7471c3af59765072b126b0ff08fc7
https://doi.org/10.1002/prca.201400120
https://doi.org/10.1002/prca.201400120
Autor:
Jianhe Peng, Rosamonde E. Banks, David A Cairns, Robert E. Coleman, Valerie Speirs, Jules A. Westbrook, Andrew M. Hanby, H Marshall, Janet E. Brown, Ingunn Holen, Peter Selby
Publikováno v:
Cancer Research. 73:P2-11
Background Bone is the commonest site of metastasis in breast cancer and bone metastasis is associated with skeletal complications and reduced quality of life. Adjuvant use of zoledronic acid (ZA) has been explored to prevent or reduce development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bbbf21c2f7d98b6198532781f45fa4a
https://doi.org/10.1158/0008-5472.sabcs13-p2-11-07
https://doi.org/10.1158/0008-5472.sabcs13-p2-11-07
The analysis of complex proteomes is undertaken using a variety of techniques and technologies such as 2-DE, surface-enhanced laser desorption ionisation, and various types of MS. In order to overcome the complexities of protein expression in discret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007334ff6dad8598f40326137270f015
https://ora.ox.ac.uk/objects/uuid:534b4ece-0490-4c16-898e-01f3c04d2b41
https://ora.ox.ac.uk/objects/uuid:534b4ece-0490-4c16-898e-01f3c04d2b41
Autor:
Nathalie J. Lafranchi-Tristem, Michael J. Dunn, Jules A. Westbrook, Alfried P. Vogler, Alexandra Cieslak
Publikováno v:
ELECTROPHORESIS. 28:535-544
In a proteomic approach using 2-DE, the changes in protein expression patterns in wing imaginal discs induced by hormone treatment have been studied. Here we show the response of butterfly imaginal wing disc tissue taken from late fifth instar larvae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db201da8efbb6d5d768323b06ecb6d5c
https://doi.org/10.1002/elps.200600620
https://doi.org/10.1002/elps.200600620
Autor:
Penelope D. Ottewell, Matthew Walker, Hannah K Brown, Ingunn Holen, Robert E. Coleman, Simon S. Cross, C. Alyson Evans, Peter Selby, Faith Nutter, Jules A. Westbrook, Janet E. Brown
Publikováno v:
Endocrine-related cancer. 21(2)
Advanced breast cancer is associated with the development of incurable bone metastasis. The two key processes involved, tumour cell homing to and subsequent colonisation of bone, remain to be clearly defined. Genetic studies have indicated that diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277d4ed2f5a36e3617a6f44f334283da
https://pubmed.ncbi.nlm.nih.gov/24413608
https://pubmed.ncbi.nlm.nih.gov/24413608
Publikováno v:
ELECTROPHORESIS. 22:2865-2871
Two-dimensional gel electrophoresis (2-DE) enables separation of complex mixtures of proteins on a single polyacrylamide gel according to isoelectric point, molecular weight, solubility, and relative abundance. For this reason, 2-DE together with mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545bd7eb37cf88c197f7c6c6075c17b4
https://doi.org/10.1002/1522-2683(200108)22:14<2865::aid-elps2865>3.0.co
https://doi.org/10.1002/1522-2683(200108)22:14<2865::aid-elps2865>3.0.co
Publikováno v:
PROTEOMICS. 1:370-376
Two-dimensional gel electrophoresis (2-DE) remains the method of choice for the Separation of protein mixtures whilst mass spectrometry (MS) is rapidly becoming the premier tool for protein identification. When combined, 2-DE and MS form the current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a0b956764ac0cb521c5d8365ef1451
https://doi.org/10.1002/1615-9861(200103)1:3<370::aid-prot370>3.0.co
https://doi.org/10.1002/1615-9861(200103)1:3<370::aid-prot370>3.0.co
Publikováno v:
Cancer treatment reviews. 40(1)
Despite well-recognised advances in breast cancer treatment, there remain substantial numbers of patients who develop metastatic disease, of which up to 70% involves spread to bone, resulting in skeletal complications which have a major negative impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f47ca3dcd8e2f8b0d195fd248851f37
https://pubmed.ncbi.nlm.nih.gov/23958309
https://pubmed.ncbi.nlm.nih.gov/23958309