Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif.

Autor: Xi Liu, Teruyuki Sano, Yongsheng Guan, Shigekazu Nagata, Jules A Hoffmann, Hidehiro Fukuyama

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42725 (2012)

Innate immune responses against DNA are essential to counter both pathogen infections and tissue damages. Mammalian EYAs were recently shown to play a role in regulating the innate immune responses against DNA. Here, we demonstrate that the unique Dr

Externí odkaz: https://doaj.org/article/398f6804122a4533a9832b05fc60df37

Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut.

Autor: Shin-Hong Shiao, Miranda M A Whitten, Daniel Zachary, Jules A Hoffmann, Elena A Levashina

Publikováno v: PLoS Pathogens, Vol 2, Iss 12, p e133 (2006)

The midgut epithelium of the mosquito malaria vector Anopheles is a hostile environment for Plasmodium, with most parasites succumbing to host defenses. This study addresses morphological and ultrastructural features associated with Plasmodium berghe

Externí odkaz: https://doaj.org/article/c0f97fca7f0747678f70ef4bae700166

Toll-mediated airway homeostasis is essential for fly survival upon injection of RasV12-GFP oncogenic cells

Autor: Shanming Ji, Xiaojing Zhou, Jules A. Hoffmann

Publikováno v: Cell Reports, Vol 43, Iss 2, Pp 113677- (2024)

Summary: Toll signaling is well known for its pivotal role in the host response against the invasion of external pathogens. Here, we investigate the potential involvement of Toll signaling in the intersection between the host and oncogenic cells. We

Externí odkaz: https://doaj.org/article/7a592ff38e444a9ab1419afce1a475d6

A Toll pathway effector protects Drosophila specifically from distinct toxins secreted by a fungus or a bacterium

Autor: Jianqiong Huang, Yanyan Lou, Jiyong Liu, Philippe Bulet, Chuping Cai, Kaiyu Ma, Renjie Jiao, Jules A. Hoffmann, Samuel Liégeois, Zi Li, Dominique Ferrandon

Publikováno v: Proceedings of the National Academy of Sciences. 120

The Drosophila systemic immune response against many Gram-positive bacteria and fungi is mediated by the Toll pathway. How Toll-regulated effectors actually fulfill this role remains poorly understood as the known Toll-regulated antimicrobial peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44a1b680235887c1e1f4b30d1b133c74
https://doi.org/10.1073/pnas.2205140120

A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defenses

Autor: Wenmin Fan, Di Chen, Pragya Prakash, Xiao Lan, Akira Goto, Jules A. Hoffmann, Arghyashree Roychowdhury-Sinha

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (12), pp.e2100825118. ⟨10.1073/pnas.2100825118⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (12), pp.e2100825118. ⟨10.1073/pnas.2100825118⟩

International audience; Oncogenic RasV12 cells [A. Simcox et al., PLoS Genet. 4, e1000142 (2008)] injected into adult males proliferated massively after a lag period of several days, and led to the demise of the flies after 2 to 3 wk. The injection i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef15a884a7ea5162d314ee5c24c87a0
https://doi.org/10.1073/pnas.2100825118