Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Julen, Oyarzabal"'
Autor:
Francisco Exposito, Miriam Redrado, Diego Serrano, Silvia Calabuig-Fariñas, Aida Bao-Caamano, Sandra Gallach, Eloisa Jantus-Lewintre, Angel Diaz-Lagares, Aitor Rodriguez-Casanova, Juan Sandoval, Edurne San Jose-Eneriz, Javier Garcia, Esther Redin, Yaiza Senent, Sergio Leon, Ruben Pio, Rafael Lopez, Julen Oyarzabal, Antonio Pineda-Lucena, Xabier Agirre, Luis M. Montuenga, Felipe Prosper, Alfonso Calvo
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-16 (2024)
Abstract The treatment of non-small cell lung cancer (NSCLC) patients has significantly improved with recent therapeutic strategies; however, many patients still do not benefit from them. As a result, new treatment approaches are urgently needed. In
Externí odkaz:
https://doaj.org/article/6e85bcef9c6c4041a19b62d5fdc24ce3
Autor:
Edurne San José-Enériz, Naroa Gimenez-Camino, Obdulia Rabal, Leire Garate, Estibaliz Miranda, Nahia Gómez-Echarte, Fernando García, Stella Charalampopoulou, Elena Sáez, Amaia Vilas-Zornoza, Patxi San Martín-Uriz, Luis V. Valcárcel, Naroa Barrena, Diego Alignani, Luis Esteban Tamariz-Amador, Ana Pérez-Ruiz, Sebastian Hilscher, Mike Schutkowski, Ana Alfonso-Pierola, Nicolás Martinez-Calle, María José Larrayoz, Bruno Paiva, María José Calasanz, Javier Muñoz, Marta Isasa, José Ignacio Martin-Subero, Antonio Pineda-Lucena, Julen Oyarzabal, Xabier Agirre, Felipe Prósper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Despite the development of novel therapies for acute myeloid leukemia, outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the
Externí odkaz:
https://doaj.org/article/c19f4277205c445384d53303bce19ff2
Autor:
Daniel Jericó, Karol M. Córdoba, Lei Jiang, Caroline Schmitt, María Morán, Ana Sampedro, Manuel Alegre, María Collantes, Eva Santamaría, Estíbaliz Alegre, Corinne Culerier, Ander Estella-Hermoso de Mendoza, Julen Oyarzabal, Miguel A. Martín, Iván Peñuelas, Matías A. Ávila, Laurent Gouya, Paolo G.V. Martini, Antonio Fontanellas
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 207-219 (2021)
Variegate porphyria (VP) results from haploinsufficiency of protoporphyrinogen oxidase (PPOX), the seventh enzyme in the heme synthesis pathway. There is no VP model that recapitulates the clinical manifestations of acute attacks. Combined administra
Externí odkaz:
https://doaj.org/article/f0e88f862dcd434c9fb48ea42beb448a
Autor:
Antonio Garcia-Gomez, Tianlu Li, Carlos de la Calle-Fabregat, Javier Rodríguez-Ubreva, Laura Ciudad, Francesc Català-Moll, Gerard Godoy-Tena, Montserrat Martín-Sánchez, Laura San-Segundo, Sandra Muntión, Xabier Morales, Carlos Ortiz-de-Solórzano, Julen Oyarzabal, Edurne San José-Enériz, Manel Esteller, Xabier Agirre, Felipe Prosper, Mercedes Garayoa, Esteban Ballestar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mesenchymal stromal cells (MSCs) have been shown to support multiple myeloma (MM) development. Here, MSCs isolated from the bone marrow of MM patients are shown to have altered DNA methylation patterns and a methyltransferase inhibitor reverts MM-ass
Externí odkaz:
https://doaj.org/article/97c0cd9d38aa419d8042bda6761115e0
Publikováno v:
Journal of Cheminformatics, Vol 10, Iss 1, Pp 1-19 (2018)
Abstract Epigenetic therapies are being investigated for the treatment of cancer, cognitive disorders, metabolic alterations and autoinmune diseases. Among the different epigenetic target families, protein lysine methyltransferases (PKMTs), are espec
Externí odkaz:
https://doaj.org/article/7fc2e2566987484cbf22e578a7ad0e5d
Autor:
Edurne San José-Enériz, Xabier Agirre, Obdulia Rabal, Amaia Vilas-Zornoza, Juan A. Sanchez-Arias, Estibaliz Miranda, Ana Ugarte, Sergio Roa, Bruno Paiva, Ander Estella-Hermoso de Mendoza, Rosa María Alvarez, Noelia Casares, Victor Segura, José I. Martín-Subero, François-Xavier Ogi, Pierre Soule, Clara M. Santiveri, Ramón Campos-Olivas, Giancarlo Castellano, Maite Garcia Fernandez de Barrena, Juan Roberto Rodriguez-Madoz, Maria José García-Barchino, Juan Jose Lasarte, Matias A Avila, Jose Angel Martinez-Climent, Julen Oyarzabal, Felipe Prosper
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Epigenetic drugs are emerging as a powerful therapeutic option for cancer treatment. Here, the authors synthesized selective chemical probes that simultaneously inhibit the G9a and DNMTs methyltransferase activity and demonstrate their anti-tumour ac
Externí odkaz:
https://doaj.org/article/286f3156e84448249eb1c05f274be064
Autor:
Mar Cuadrado-Tejedor, Marta Pérez-González, Cristina García-Muñoz, Damián Muruzabal, Carolina García-Barroso, Obdulia Rabal, Víctor Segura, Juan A. Sánchez-Arias, Julen Oyarzabal, Ana Garcia-Osta
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
The discouraging results with therapies for Alzheimer’s disease (AD) in clinical trials, highlights the urgent need to adopt new approaches. Like other complex diseases, it is becoming clear that AD therapies should focus on the simultaneous modula
Externí odkaz:
https://doaj.org/article/406af94d56d34149a280e4d9333bb21a
Autor:
Jose A. Martinez-Climent, Felipe Prosper, Oscar Yanes, Xabier Agirre, Maria D. Odero, Maria J. Moreno-Aliaga, Bruno Paiva, Alvaro Martinez-Baztan, Julen Oyarzabal, Ruben Pio, Puri Fortes, Celia Prior, Jiahuai Han, Alexandra Junza, Carlos Panizo, Maria J. Calasanz, Maria J. Larrayoz, Marta Fernandez-Galilea, Carmen Vicente, Jon Celay, Marta Larrayoz, Maria J. Garcia-Barchino, Vicente Fresquet
For millions of years, endogenous retroelements have remained transcriptionally silent within mammalian genomes by epigenetic mechanisms. Modern anticancer therapies targeting the epigenetic machinery awaken retroelement expression, inducing antivira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd38133a1d3d0fc69bfac72ef54132a
https://doi.org/10.1158/2159-8290.c.6549353.v1
https://doi.org/10.1158/2159-8290.c.6549353.v1
Autor:
Jose A. Martinez-Climent, Felipe Prosper, Oscar Yanes, Xabier Agirre, Maria D. Odero, Maria J. Moreno-Aliaga, Bruno Paiva, Alvaro Martinez-Baztan, Julen Oyarzabal, Ruben Pio, Puri Fortes, Celia Prior, Jiahuai Han, Alexandra Junza, Carlos Panizo, Maria J. Calasanz, Maria J. Larrayoz, Marta Fernandez-Galilea, Carmen Vicente, Jon Celay, Marta Larrayoz, Maria J. Garcia-Barchino, Vicente Fresquet
Supplementary Figures S1-S7 with legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cd1ba7e34a4f91806bf9b7dfe5c665
https://doi.org/10.1158/2159-8290.22540328.v1
https://doi.org/10.1158/2159-8290.22540328.v1
Autor:
Jose A. Martinez-Climent, Felipe Prosper, Oscar Yanes, Xabier Agirre, Maria D. Odero, Maria J. Moreno-Aliaga, Bruno Paiva, Alvaro Martinez-Baztan, Julen Oyarzabal, Ruben Pio, Puri Fortes, Celia Prior, Jiahuai Han, Alexandra Junza, Carlos Panizo, Maria J. Calasanz, Maria J. Larrayoz, Marta Fernandez-Galilea, Carmen Vicente, Jon Celay, Marta Larrayoz, Maria J. Garcia-Barchino, Vicente Fresquet
Resources Table and Suppl. Tables. S1-S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c062deac21564ce858ab3b68ff8059
https://doi.org/10.1158/2159-8290.22540331
https://doi.org/10.1158/2159-8290.22540331