Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jule Focken"'
Autor:
Jule Focken, Birgit Schittek
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionStaphylococcus aureus (S. aureus) infection of the skin leads to a rapid initial innate immune response with keratinocytes in the epidermis as the initial sensors. Polymorphonuclear neutrophils (PMNs) are the first innate immune cells to
Externí odkaz:
https://doaj.org/article/65559cf63b6b4dd2905b293fae5e23eb
Autor:
Jasmin Scheurer, Birgit Sauer, Jule Focken, Martina Giampetraglia, Annika Jäger, Christian M. Schürch, Bettina Weigelin, Birgit Schittek
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/b2e76f21dbe54f03bff62133e9c45c41
Autor:
Jule Focken, Jasmin Scheurer, Annika Jäger, Christian M. Schürch, Sofie Kämereit, Simon Riel, Martin Schaller, Bettina Weigelin, Birgit Schittek
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113148- (2023)
Summary: Staphylococcus aureus is the most common cause of bacterial skin infections in humans, including patients with atopic dermatitis (AD). Polymorphonuclear neutrophils (PMNs) are the first cells to infiltrate an infection site, where they usual
Externí odkaz:
https://doaj.org/article/18ee08d62d964e14bd212678ec2667c9
Autor:
Katharina Bitschar, Birgit Sauer, Jule Focken, Hanna Dehmer, Sonja Moos, Martin Konnerth, Nadine A. Schilling, Stephanie Grond, Hubert Kalbacher, Florian C. Kurschus, Friedrich Götz, Bernhard Krismer, Andreas Peschel, Birgit Schittek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Lugdunin is a peptide antibiotic produced by the skin commensal Staphylococcus lugdunensis. Here, the authors show that lugdunin reduces Staphylococcus aureus colonization in human keratinocytes and mouse skin by inducing the expression of human LL-3
Externí odkaz:
https://doaj.org/article/cdeeef7531844cd4aa56780138aa628c
Autor:
Phil Oberacker, Peter Stepper, Donna M Bond, Sven Höhn, Jule Focken, Vivien Meyer, Luca Schelle, Victoria J Sugrue, Gert-Jan Jeunen, Tim Moser, Steven R Hore, Ferdinand von Meyenn, Katharina Hipp, Timothy A Hore, Tomasz P Jurkowski
Publikováno v:
PLoS Biology, Vol 17, Iss 1, p e3000107 (2019)
Current molecular biology laboratories rely heavily on the purification and manipulation of nucleic acids. Yet, commonly used centrifuge- and column-based protocols require specialised equipment, often use toxic reagents, and are not economically sca
Externí odkaz:
https://doaj.org/article/13517a35600a4c7ab15be98c00862666
Publikováno v:
Experimental Dermatology. 31:349-361
Staphylococcus aureus colonization is abundant on the skin of atopic dermatitis (AD) patients where it contributes to skin inflammation. S. aureus produces virulence factors that distinguish it from commensal skin bacteria such as S. epidermidis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdba4772bbb127d846178b80285edac1
https://doi.org/10.1111/exd.14478
https://doi.org/10.1111/exd.14478
Autor:
Francesca Bork, Carsten L. Greve, Christine Youn, Sirui Chen, Yu Wang, Masoud Nasri, Jule Focken, Jasmin Scheurer, Pujan Engels, Marissa Dubbelaar, Katharina Hipp, Birgit Schittek, Stefanie Bugl, Markus W. Löffler, Julia Skokowa, Nathan K. Archer, Alexander N.R. Weber
Publikováno v:
SSRN Electronic Journal.
Neutrophil extracellular traps (NETs) are a key antimicrobial feature of cellular innate immunity mediated by polymorphonuclear neutrophils (PMNs), the primary human leukocyte population. NETs trap and kill microbes but have also been linked to infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8f439cdb2d482e606710cffb24ab63
https://doi.org/10.2139/ssrn.4244243
https://doi.org/10.2139/ssrn.4244243
Autor:
Jule Focken, Laura Klink, Zsofia Bittner, Martin Schaller, Lena Staudenmaier, Franziska Herster, Lisa Bleul, Birgit Schittek, Christiane Wolz, Andreas Peschel, Birgit Fehrenbacher, Birgit Sauer, Katharina Bitschar, Alexander N.R. Weber
Publikováno v:
Journal of Investigative Dermatology. 140:1054-1065.e4
Staphylococcus aureus is a facultative pathogen found on skin and nasal surfaces. It is usually absent from the skin of healthy humans but frequently colonizes the skin of patients with atopic dermatitis. Here, we investigate the functional role of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0386ea8d6d49dd262ce5c2a026acc9
https://doi.org/10.1016/j.jid.2019.10.017
https://doi.org/10.1016/j.jid.2019.10.017
Autor:
Birgit Schittek, Katharina Bitschar, Sonja Moos, Martin C. Konnerth, Jule Focken, Stephanie Grond, Florian C. Kurschus, Nadine A. Schilling, Hubert Kalbacher, Birgit Sauer, Hanna Dehmer, Andreas Peschel, Friedrich Götz, Bernhard Krismer
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Recently our groups discovered lugdunin, a new cyclic peptide antibiotic that inhibits Staphylococcus aureus epithelial colonization in humans and rodents. In this work, we analyzed its immuno-modulatory and antimicrobial potential as a single agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02f406d3190b5352bd64757e910b805
https://pubmed.ncbi.nlm.nih.gov/31227691
https://pubmed.ncbi.nlm.nih.gov/31227691
Autor:
Phil Oberacker, Gert-Jan Jeunen, Jule Focken, Sven Hohn, Steven R. Hore, Luca Schelle, Timothy A. Hore, Peter Stepper, Donna M. Bond, Tomasz P. Jurkowski, Katharina Hipp, Vivien Meyer, Tim Moser, Victoria J Sugrue, Ferdinand von Meyenn
Publikováno v:
PLoS Biology, Vol 17, Iss 1, p e3000107 (2019)
PLoS Biology
PLoS Biology
Current molecular biology laboratories rely heavily on the purification and manipulation of nucleic acids. Yet, commonly used centrifuge- and column-based protocols require specialised equipment, often use toxic reagents, and are not economically sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5be196b077540de8a52b0c480e1758f
