Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Autor: Khan, K., Karim, F., Ganga, Y., Bernstein, M., Jule, Z., Reedoy, K., Cele, S., Lustig, G., Amoako, D., Wolter, N., Samsunder, N., Sivro, A., San, J., Giandhari, J., Tegally, H., Pillay, S., Naidoo, Y., Mazibuko, M., Miya, Y., Ngcobo, N., Manickchund, N., Magula, N., Karim, Q., von Gottberg, A., Karim, S., Hanekom, W., Gosnell, B., Team, C., Lessells, R., de Oliveira, T., Moosa, M., Sigal, A.

Publikováno v: Nature Communications

SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a2e7066c0c2144da64fcecff811e71
https://doi.org/10.1038/s41467-022-32396-9

SARS-CoV-2 infection in immunosuppression evolves sub-lineages which independently accumulate neutralization escape mutations.

Autor: Lustig G; Centre for the AIDS Programme of Research in South Africa, 719 Umbilo Road, Durban 4001, South Africa., Ganga Y; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa., Rodel HE; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa.; Division of Infection and Immunity, University College London, UCL Cruciform Building Gower Street, London WC1E 6BT, UK., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform, 719 Umbilo Road, Durban 4001, South Africa.; Centre for Epidemic Response and Innovation, School of Data Science and Computational Thinking, Stellenbosch University, Francie Van Zijl Drive, Cape Town 7505, South Africa., Khairallah A; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa., Jackson L; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa., Cele S; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa., Khan K; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa., Jule Z; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa., Reedoy K; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa., Karim F; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa., Bernstein M; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa., Ndung'u T; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa.; Division of Infection and Immunity, University College London, UCL Cruciform Building Gower Street, London WC1E 6BT, UK.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa.; HIV Pathogenesis Programme, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa.; Ragon Institute of MGH, MIT and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA., Moosa MS; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa., Archary D; Centre for the AIDS Programme of Research in South Africa, 719 Umbilo Road, Durban 4001, South Africa., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform, 719 Umbilo Road, Durban 4001, South Africa.; Centre for Epidemic Response and Innovation, School of Data Science and Computational Thinking, Stellenbosch University, Francie Van Zijl Drive, Cape Town 7505, South Africa.; Department of Global Health, University of Washington, 3980 15th Avenue NE, Seattle, WA 98105, USA., Lessells R; KwaZulu-Natal Research Innovation and Sequencing Platform, 719 Umbilo Road, Durban 4001, South Africa., Neher RA; SIB Swiss Institute of Bioinformatics, Quartier Sorge - Bâtiment Amphipôle, Lausanne 1015, Switzerland.; Biozentrum, University of Basel, Spitalstrasse 41 4056, Basel, Switzerland., Abdool Karim SS; Centre for the AIDS Programme of Research in South Africa, 719 Umbilo Road, Durban 4001, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, United States., Sigal A; Centre for the AIDS Programme of Research in South Africa, 719 Umbilo Road, Durban 4001, South Africa.; Africa Health Research Institute, 719 Umbilo Road, Durban 4001, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa.

Publikováno v: Virus evolution [Virus Evol] 2023 Dec 28; Vol. 10 (1), pp. vead075. Date of Electronic Publication: 2023 Dec 28 (Print Publication: 2024).

SARS-CoV-2 evolves increased infection elicited cell death and fusion in an immunosuppressed individual.

Autor: Lustig G; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Ganga Y; Africa Health Research Institute, Durban, South Africa., Rodel H; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Division of Infection and Immunity, University College London, London, UK., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Jackson L; Africa Health Research Institute, Durban, South Africa., Cele S; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Khan K; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Jule Z; Africa Health Research Institute, Durban, South Africa., Reedoy K; Africa Health Research Institute, Durban, South Africa., Karim F; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Bernstein M; Africa Health Research Institute, Durban, South Africa., Moosa MS; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Archary D; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.; Department of Global Health, University of Washington, Seattle, USA., Lessells R; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Abdool Karim SS; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States., Sigal A; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2022 Nov 30. Date of Electronic Publication: 2022 Nov 30.

Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26.CoV2.S Vaccination in People Living With Human Immunodeficiency Virus (HIV).

Autor: Khan K; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Lustig G; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Bernstein M; Africa Health Research Institute, Durban, South Africa., Archary D; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa., Cele S; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Karim F; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Smith M; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Ganga Y; Africa Health Research Institute, Durban, South Africa., Jule Z; Africa Health Research Institute, Durban, South Africa., Reedoy K; Africa Health Research Institute, Durban, South Africa., Miya Y; Africa Health Research Institute, Durban, South Africa., Mthabela N; Africa Health Research Institute, Durban, South Africa., Magula NP; Department of Medicine, King Edward VIII Hospital and University of KwaZulu Natal, Durban, South Africa., Lessells R; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., de Oliveira T; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.; Centre for Epidemic Response and Innovation, School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.; Department of Global Health, University of Washington, Seattle, Washington, USA., Gosnell BI; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Abdool Karim S; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA., Garrett N; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa., Hanekom W; Africa Health Research Institute, Durban, South Africa.; Division of Infection and Immunity, University College London, London, United Kingdom., Bekker LG; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Desmond Tutu HIV Centre, Cape Town, South Africa., Gray G; South African Medical Research Council, Cape Town, South Africa., Blackburn JM; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Sengenics Corporation, Kuala Lumpur, Malaysia., Moosa MS; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Sigal A; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2022 Aug 24; Vol. 75 (1), pp. e857-e864.

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization.

Autor: Cele S; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Jackson L; Africa Health Research Institute, Durban, South Africa., Khoury DS; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia., Khan K; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Moyo-Gwete T; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.; Centre for Epidemic Response and Innovation, School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa., San JE; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Cromer D; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia., Scheepers C; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Amoako DG; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa., Karim F; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Bernstein M; Africa Health Research Institute, Durban, South Africa., Lustig G; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Archary D; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa., Smith M; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Ganga Y; Africa Health Research Institute, Durban, South Africa., Jule Z; Africa Health Research Institute, Durban, South Africa., Reedoy K; Africa Health Research Institute, Durban, South Africa., Hwa SH; Africa Health Research Institute, Durban, South Africa.; Division of Infection and Immunity, University College London, London, UK., Giandhari J; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., Blackburn JM; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Gosnell BI; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Abdool Karim SS; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA., Hanekom W; Africa Health Research Institute, Durban, South Africa.; Division of Infection and Immunity, University College London, London, UK., von Gottberg A; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Bhiman JN; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Lessells RJ; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Moosa MS; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Davenport MP; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia., de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.; Centre for Epidemic Response and Innovation, School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Department of Global Health, University of Washington, Seattle, WA, USA., Moore PL; National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.; SA MRC Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Sigal A; Africa Health Research Institute, Durban, South Africa. alex.sigal@ahri.org.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa. alex.sigal@ahri.org.; Max Planck Institute for Infection Biology, Berlin, Germany. alex.sigal@ahri.org.

Publikováno v: Nature [Nature] 2022 Feb; Vol. 602 (7898), pp. 654-656. Date of Electronic Publication: 2021 Dec 23.