Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Juko Sugihara"'
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Studies on the Metabolic Fate of TA-510, a Hepatic Anti-inflammatory Agent. (1). Blood Concentration, Distribution and Excretion in Bats and Dogs
Autor: Kazuyuki Hirakoso, Toshiyuki Kume, Masayoshi Yoshikawa, Juko Sugihara
Publikováno v: Drug Metabolism and Pharmacokinetics. 15:318-326
Pharmacokinetics in the plasma, tissue distribution and excretion of TA-510, a novel hepatic agent, were investigated after a single oral (30 mg/kg) or intravenous (3 mg/kg) administration of 14C-labeled TA-510 to male rats and dogs. 1. The absorptio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55e7ca6011c6e64612b22e25eff1bfae
https://doi.org/10.2133/dmpk.15.318
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4
Disposition of Taltirelin. (2): The Transfers into the Fetus and Milk, Sex-Related Difference after Single Oral Administration and Blood Concentration after Repeated Oral Dosing in Rats
Autor: Hirohiko Kodama, Juko Sugihara, Akiko Kono, Masayoshi Yoshikawa
Publikováno v: Drug Metabolism and Pharmacokinetics. 12:475-482
The transfers of 14C-taltirelin into the fetus and milk and sex-related difference were investigated after a single oral administration of 14C-taltirelin at a dose of 3 mg/kg to rats. The blood level after repeat ed oral dosing was also studied. 1. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b06a9db8903c13188e2fc4a2f5ebfb8
https://doi.org/10.2133/dmpk.12.475
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5
Accumulation of Radioactivity in Rat Brain and Peripheral Tissues Including Salivary Gland after Intravenous Administration of 14C-D-aspartic Acid
Autor: Kazuhiro Imai, Takeshi Fukushima, Hiroshi Homma, Juko Sugihara, Tomofumi Santa, Hirohiko Kodama, Masayoshi Yoshikawa
Publikováno v: Proceedings of the Japan Academy, Series B. 73:48-52
After the intravenous administration of 14C-D-aspartic acid (Asp) into Sprague-Dawley rats (male, 7-week-old), the distribution and elimination of radioactivity was investigated by the whole body autoradiography. High radioactivities were detected in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f6383db9327a3d4e110787753855c09
https://doi.org/10.2183/pjab.73.48
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6
Disposition of Taltirelin. (3): The Transfer into the Brain and Brain Distribution in Rats
Autor: Juko Sugihara, Hirohiko Kodama, Susumu Chishima, Takeshi Fukushima, Masayoshi Yoshikawa
Publikováno v: Drug Metabolism and Pharmacokinetics. 12:483-490
The transfer, distribution and degradation of taltirelin in the brain were investigated after oral (3 mg/kg) or intravenous (1 mg/kg) administration and injection into cisterna cerebellomedullaris (300 μg/kg) in rats. 1. Taltirelin was hardly degrad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91a805c537643c556374d092305d23f3
https://doi.org/10.2133/dmpk.12.483
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7
Disposition of Taltirelin. (1): Absorption, Distribution, Metabolism and Excretion in Rats and Dogs
Autor: Masakatsu Takahashi, Masayoshi Yoshikawa, Satoshi Furuuchi, Hirohiko Kodama, Juko Sugihara
Publikováno v: Drug Metabolism and Pharmacokinetics. 12:460-474
The absorption, distribution, excretion and metabolism were investigated after a single oral (3 mg/kg) or intravenous (1 mg/kg) administration of 14C-taltirelin to male rats and dogs. 1. The extent of absorption calculated from the ratio of urinary e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b8ff489e03b89e5ef342ab8bd3c3952
https://doi.org/10.2133/dmpk.12.460
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8
Chronic anti-ataxic actions of the novel thyrotropin-releasing hormone (TRH) analog, TA-0910, during and after repeated administration in Rolling mouse Nagoya: behavioral and pharmacokinetic studies
Autor: Yuzo Matsuoka, Takeshi Fukushima, Kiyoshi Kinoshita, Yasuhiko Kodama, Juko Sugihara, Michio Yamamura
Publikováno v: Biologicalpharmaceutical bulletin. 20(1)
Anti-ataxic effects of TA-0910, a novel thyrotropin-releasing hormone analog, in mice of the ataxic mutant mouse strain Rolling mouse Nagoya (RMN) are sustained beyond its 2-week oral administration period (Kinoshita et al., Eur. J. Pharmacol., 274,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0428148cfcd5372799da04a015233e9
https://pubmed.ncbi.nlm.nih.gov/9013803
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9
Distribution of thyrotropin-releasing hormone (TRH) receptors in the brain of the ataxic mutant mouse, rolling mouse Nagoya
Autor: Kiyoshi Kinoshita, Michio Yamamura, Juko Sugihara
Publikováno v: Biologicalpharmaceutical bulletin. 20(1)
Thyrotropin-releasing hormone (TRH) and its analog, TA-0910, ameliorate the ataxia of the mutant mouse, rolling mouse Nagoya, by metabolic normalization in the ventral tegmental field (VTF). We here investigated the distribution of cerebral TRH recep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86aa82e1195aec5bf1494e90ad8caf83
https://pubmed.ncbi.nlm.nih.gov/9013814
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10
Metabolic Fate of Timepidium Bromide (SA-504)
Autor: Juko Sugihara, Naomasa Taga
Publikováno v: RADIOISOTOPES. 26:238-244
The colored substances excreted in bile or urine have bee investigated after adminstration of a high dose of SQ-504 to rats. A reddish-violet colored substance and a bluish-violet colored substance were dominant. Their chemical structures were not as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0433d3205eb285b10900c3777bfd6709
https://doi.org/10.3769/radioisotopes.26.4_238
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