Influence of long-term postmenopausal hormone-replacement therapy on estimated structural bone strength: A study in discordant monozygotic twins

Autor: Paula H. A. Ronkainen, Vuokko Kovanen, Markku Koskenvuo, Harri Suominen, Jukka Puolakka, Tuija M. Mikkola, Sulin Cheng, Carina Ankarberg-Lindgren, Ari Heinonen, Jaakko Kaprio, Markku Alen, Taina Rantanen, Sarianna Sipilä, Urho M. Kujala

Publikováno v: Journal of Bone and Mineral Research. 26:546-552

Although postmenopausal hormone-replacement therapy (HRT) is known to prevent fractures, knowledge on the influence of long-term HRT on bone strength and its determinants other than areal bone mineral density is scarce. This study used a genetically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a170bad930caaf3369886b531e59f83f
https://doi.org/10.1002/jbmr.255

Power training and postmenopausal hormone therapy affect transcriptional control of specific co-regulated gene clusters in skeletal muscle

Autor: Paula H. A. Ronkainen, Satu O A Koskinen, Dennis R. Taaffe, Urho M. Kujala, Timo Törmäkangas, Eija Pöllänen, Sulin Cheng, Vuokko Kovanen, Timo Takala, Harri Suominen, Vidal Fey, Jukka Puolakka, Sarianna Sipilä

Publikováno v: AGE
Pöllänen, E, Fey, V, Törmäkangas, T, Ronkainen, P H A, Taaffe, D R, Takala, T, Koskinen, S, Cheng, S, Puolakka, J, Kujala, U M, Suominen, H, Sipilä, S & Kovanen, V 2010, ' Power training and postmenopausal hormone therapy affect transcriptional control of specific co-regulated gene clusters in skeletal muscle ', Age, vol. 32, no. 3, pp. 347-363 . https://doi.org/10.1007/s11357-010-9140-1
AGE; Vol 32
Age

At the moment, there is no clear molecular explanation for the steeper decline in muscle performance after menopause or the mechanisms of counteractive treatments. The goal of this genome-wide study was to identify the genes and gene clusters through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc82a15126f5dc35aecf970f4f11f280

The effect of hormone replacement therapy and/or exercise on skeletal muscle attenuation in postmenopausal women: a yearlong intervention

Autor: Dennis R. Taaffe, Harri Suominen, Jukka Puolakka, Jarmo Toivanen, Sarianna Sipilä, Sulin Cheng

Publikováno v: Scopus-Elsevier

Hormone replacement therapy (HRT) has been reported to exert a positive effect on preserving muscle strength following the menopause, however, the mechanism of action remains unclear. We examined whether the mechanism involved preservation of muscle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bde71ca0cf93d944f04fea246bad6f4
https://doi.org/10.1111/j.1475-097x.2005.00628.x

Different Effects of Oral and Transdermal Hormonal Replacement on Prostacyclin and Thromboxane A2

Autor: Arto Orpana, Jukka Puolakka, Olavi Ylikorkala, Lasse Viinikka, T. Pyörälä

Publikováno v: Obstetrics & Gynecology. 89:104-107

To elucidate the mechanism of cardiovascular protection of hormone replacement therapy (HRT) by comparing the effect of oral and transdermal HRTs on the production of antiaggregatory, vasodilatory prostacyclin, and its endogenous antagonist, thrombox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6a74c25df954c75550f28e7095e4d5
https://doi.org/10.1016/s0029-7844(96)00379-1

Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy

Autor: Paula H A, Ronkainen, Eija, Pöllänen, Markku, Alén, Reino, Pitkänen, Jukka, Puolakka, Urho M, Kujala, Jaakko, Kaprio, Sarianna, Sipilä, Vuokko, Kovanen

Publikováno v: Aging cell. 9(6)

Aging is accompanied by inexorable loss of muscle tissue. One of the underlying causes for this is the massive change in the hormonal milieu of the body. The role of a female sex steroid - estrogen - in these processes is frequently neglected, althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f0506835fd035c0f9e69ee9b7f1c722
https://pubmed.ncbi.nlm.nih.gov/20883525