Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Jukka Hiltunen"'
Autor:
Markku Miettinen, Helena Leijon, Annamari Heiskanen, Tero Satomaa, Caj Haglund, Tuomas Kaprio, Johanna Arola, Jukka Hiltunen
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 102:3990-4000
Context No effective methods for separating primary pheochromocytomas and paragangliomas with metastatic potential are currently available. The identification of specific asparagine-linked glycan (N-glycan) structures, which are associated with metas
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:206-210
The aim of this study was to develop a direct fluorination method for the preparation of [18F]-(E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4′-methyl-phenyl)nortropane ([18F]FE-PE2I (VI). The synthesis procedure relies on the conventional K
Autor:
Christer Halldin, Jukka Hiltunen, Johnny Vercouillie, Balázs Gulyás, Denis Guilloteau, Patrick Emond, Judit Sovago, Jari Tarkiainen, Johan Lundberg, Sylvie Chalon, Lars Farde
Publikováno v:
Synapse. 58:173-183
The aim of this study was to explore the potential of a new selective serotonin transporter (5-HTT) inhibitor, N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine (MADAM, K(i)=1.65 nM), as a PET radioligand for examination of 5-HTT in the nonhuman
Publikováno v:
Veterinary Surgery. 32:402-409
Objectives— To evaluate the effects of radiation synovectomy (RSYN) with holmium-166 ferric hydroxide macroaggregate (Ho-166 FHMA) on synovium and synovial fluid in normal metacarpo- and metatarsophalangeal joints of horses and to determine intraar
Autor:
Jukka Hiltunen, Håkan Hall, Terttu Särkioja, Erkki Tupala, Jari Tiihonen, Kim A. Bergström, Tuija Mantere, Pirkko Räsänen
Publikováno v:
Synapse. 48:205-211
It is generally agreed that there is a deterioration in brain dopamine (DA) system with aging. The role of the mesolimbic DA in brain ethanol reinforcement is well established, with nucleus accumbens (NAC) serving as a major terminal area of this sys
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 30:132-136
[(123)I]ADAM [2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM)] has recently been shown to be a very promising imaging ligand for the detection of serotonin transporters (SERT) in human brain, because of its high specificity for SER
Autor:
Jyrki T. Kuikka, Antony D. Gee, Meixiang Yu, Jukka Hiltunen, Simo Lötjönen, Anu J. Airaksinen, Kim A. Bergström, Jouko Vepsäläinen
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 45:1011-1017
The radiosynthesis of a novel tropane derivative [123I]KUC-25019, [[123I];N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3β-(3′,4′-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes inclu
Autor:
Andreas Pfestroff, Jan-Erik Westlin, Rudolf Arnold, Sten Nilsson, Jin Du, Jukka Hiltunen, Ulrich Wulbrand, Marcela Márquez, Martin Feldman, Hans‐Cristophe Fehman, Anders R. Holmberg
Publikováno v:
Cancer. 94:1293-1297
BACKGROUND Somatostatin receptors (SRS, five subtypes) are expressed in a variety of human tumors, including most tumors of neuroendocrine origin, breast tumors, certain brain tumors, renal cell tumors, lymphomas, and prostate cancer. Somatostatin (S
Autor:
Pirkko Räsänen, Jyrki T. Kuikka, Erkki Tupala, Jari Tiihonen, Terttu Särkioja, Jukka Hiltunen, Jouko Vepsäläinen, Kim A. Bergström, Tuija Mantere, Håkan Hall
Publikováno v:
NeuroImage. 14:87-94
Dopaminergic mechanisms are involved in the positive reinforcing and addicting effects of alcohol. Positron emission tomography (PET) and single photon emission tomography (SPET) studies have indicated alterations in striatal dopamine transporters (D
Autor:
Erkki Tupala, Terttu Särkioja, Tuija Mantere, Jukka Hiltunen, Kim A. Bergström, Jari Tiihonen, Pirkko Räsänen, Håkan Hall, J. C. Callaway
Publikováno v:
Molecular Psychiatry. 6:261-267
Alcohol acts through mechanisms involving the brain neurotransmitter dopamine (DA) with the nucleus accumbens as the key zone for mediating these effects. We evaluated the densities of DA D(2)/D(3) receptors and transporters in the nucleus accumbens