Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jukka Hartikka"'
Autor:
Larry R. Smith, Jian Ben Wang, Xiaohong Cui, Frances M. Saccoccio, Ronzo Lee, Stuart P. Adler, Michael A. McVoy, Jukka Hartikka, Rohit Mahajan
Publikováno v:
Vaccine. 33:7328-7336
A vaccine to prevent congenital cytomegalovirus (CMV) infections is a national priority. Investigational vaccines have targeted the viral glycoprotein B (gB) as an inducer of neutralizing antibodies and phosphoprotein 65 (pp65) as an inducer of cytot
Autor:
Denis Rusalov, Jukka Hartikka, Qun Wei, Mark Shlapobersky, Larry R. Smith, Catherine K. Yang, Ming Ye, Alain Rolland, Vesselina Bozoukova, Adrian Vilalta
Publikováno v:
Vaccine. 27:6399-6403
Mice were immunized either with unadjuvanted seasonal trivalent influenza vaccine (TIV) or TIV formulated with Vaxfectin, a cationic lipid-based adjuvant. Increasing doses of Vaxfectin resulted in increased hemagglutination-inhibition or anti-TIV ELI
Autor:
Jukka Hartikka, Terrie Martin, David C. Kaslow, Alain Rolland, Denis Rusalov, Keith Hall, Jane Morrow, Vicky Leamy, Peggy Lalor, Adrian Vilalta, Rohit Mahajan, Vesselina Bozoukova
Publikováno v:
Human Vaccines. 2:113-118
Experiments were conducted with a cationic lipid-formulated pDNA vaccine (VCL-AB01) to evaluate the models used to determine biodistribution, persistence and the potential for integration (into genomic DNA) of plasmid DNA-based vaccines. Mice were in
Publikováno v:
Human Gene Therapy. 9:2545-2553
Enhancers and promoters from various muscle-specific genes were substituted for or combined with the enhancer/promoter of the human cytomegalovirus (CMV) IE gene in a luciferase reporter gene plasmid in an effort to identify new promoter chimeras wit
Publikováno v:
Scopus-Elsevier
Gene therapy for muscular diseases requires the efficient transfection of a large proportion of myofiber cells within a given muscle. In the present experiments, patterns of beta-galactosidase expression were examined in mouse rectus femoris muscles
Autor:
Brian A. Crowe, Sean M. Sullivan, Mark Shlapobersky, Walter Wodal, Otfried Kistner, Jukka Hartikka, Helga Savidis-Dacho, Astrid Kerschbaum, Alain Rolland, Peter Dipl Biol Dr Bruehl, P. Noel Barrett, Michael G. Schwendinger, Larry R. Smith
Increasing the potency and supply of seasonal and pandemic influenza vaccines remains an important unmet medical need which may be effectively accomplished with adjuvanted egg- or cell culture-derived vaccines. Vaxfectin®, a cationic lipid-based adj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf348fbbd6c2f8b81d797554e6269ec9
https://europepmc.org/articles/PMC3901827/
https://europepmc.org/articles/PMC3901827/
Autor:
Alan D. Smith, Margaret R. Nichols, Seng H. Cheng, John Marshall, Michael Plewe, Yali J. Tsai, Jennifer B. Nietupski, Loretta Sukhu, Jon Norman, Carl J. Wheeler, S G Doh, Xiaowu Liang, Philip L. Felgner, Marston Manthorpe, Jukka Hartikka
Publikováno v:
Proceedings of the National Academy of Sciences. 93:11454-11459
Effective gene therapy for lung tissue requires the use of efficient vehicles to deliver the gene of interest into lung cells. When plasmid DNA encoding chloramphenicol acetyltransferase (CAT) was administered intranasally to BALB/c mice without carr
Autor:
Qun Wei, Sou Boutsaboualoy, Mark Shlapobersky, Alain Rolland, Jane Morrow, Vesselina Bozoukova, Mary K. Wloch, Ming Ye, Jukka Hartikka, Denis Rusalov, John A. Doukas, Sean M. Sullivan, Larry R. Smith
Human cytomegalovirus (CMV) establishes a lifelong persistent infection characterized by periods of latency and sporadic viral replication and is a major infectious cause of birth defects following congenital infection. Currently, no licensed vaccine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251a146ca0de56d3adbb6a8fa59143f9
https://europepmc.org/articles/PMC3601134/
https://europepmc.org/articles/PMC3601134/
Autor:
Marston Manthorpe, Jiin Felgner, Jukka Hartikka, Francine Cornefert-Jensen, Ann Rundell, Michal Margalith, Varavani Dwarki
Publikováno v:
Scopus-Elsevier
Direct injection of nonviral, covalently closed circular plasmid DNA into muscle results in expression of the DNA in myofiber cells. We have examined the expression of firefly luciferase DNA constructs injected into adult murine skeletal muscle. Cons
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Serotonergic neurons located at the base of the mammalian brain innervate practically every region of the brain and the spinal cord. These neurons exhibit spontaneous electrical discharges in a rhythmical way. Their firing frequency is modulated by s