Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Juin Fok-Seang"'
Autor:
Brian M. Maas, Jos Lommerse, Nele Plock, Radha A. Railkar, S.Y. Amy Cheung, Luzelena Caro, Jingxian Chen, Wen Liu, Ying Zhang, Qinlei Huang, Wei Gao, Li Qin, Jie Meng, Han Witjes, Emilie Schindler, Benjamin Guiastrennec, Francesco Bellanti, Daniel S. Spellman, Brad Roadcap, Mariya Kalinova, Juin Fok-Seang, Andrew P. Catchpole, Amy S. Espeseth, S. Aubrey Stoch, Eseng Lai, Kalpit A. Vora, Antonios O. Aliprantis, Jeffrey R. Sachs
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103651- (2021)
Background: Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody (mAb) under development to prevent RSV infection in infants. Development and validat
Externí odkaz:
https://doaj.org/article/29110f874edd46dea00e331b42ac8484
Autor:
Beate Schmoele-Thoma, Agnieszka M. Zareba, Qin Jiang, Mohan S. Maddur, Rana Danaf, Alex Mann, Kingsley Eze, Juin Fok-Seang, Golam Kabir, Andrew Catchpole, Daniel A. Scott, Alejandra C. Gurtman, Kathrin U. Jansen, William C. Gruber, Philip R. Dormitzer, Kena A. Swanson
Publikováno v:
The New England journal of medicine. 386(25)
Although human respiratory syncytial virus (RSV) is an important cause of illness and death in older adults, no RSV vaccine has been licensed.In a phase 2a study, we randomly assigned healthy adults (18 to 50 years of age), in a 1:1 ratio, to receive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9454d99b9859b1a57e7ee102b2d0219
https://pubmed.ncbi.nlm.nih.gov/35731658
https://pubmed.ncbi.nlm.nih.gov/35731658
Autor:
Bart Remmerie, John P. DeVincenzo, Young-In Kim, Dirk Roymans, Rene Verloes, Nacer Lounis, Sarah Rusch, Anil Koul, Marita Stevens, Alison Boyers, Lisa Harrison, Elizabeth A. Meals, Juin Fok-Seang, Dymphy Huntjens, Kris Mari N
Publikováno v:
The Journal of infectious diseases. 218(5)
Background Respiratory syncytial virus (RSV) disease has no effective treatment. JNJ-53718678 is a fusion inhibitor with selective activity against RSV. Methods After confirmation of RSV infection or 5 days after inoculation with RSV, participants (n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93140d9db59bcfedaefca35ee44054e4
https://pubmed.ncbi.nlm.nih.gov/29684148
https://pubmed.ncbi.nlm.nih.gov/29684148
Autor:
Alison Boyers, Samuel Israel, Juin Fok-Seang, Sarah Rusch, John P. DeVincenzo, Rene Verloes, Kris Mariёn, Dymphy Huntjens, Marita Stevens, Nacer Lounis
Publikováno v:
Open Forum Infectious Diseases. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95dc888a0c81256b07b99dfab3230d9e
https://doi.org/10.1093/ofid/ofw172.513
https://doi.org/10.1093/ofid/ofw172.513
Autor:
Joan Cao, Hua Wu, Paul Griffin, Qinghai Peng, R. Lynn Jackson, Scott L. Butler, Wade S. Blair, Edward J. Murray, Chris Pickford, Amy K. Patick, Juin Fok-Seang, Manos Perros, Jason Isaacson
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:5080-5087
A new small-molecule inhibitor class that targets virion maturation was identified from a human immunodeficiency virus type 1 (HIV-1) antiviral screen. PF-46396, a representative molecule, exhibits antiviral activity against HIV-1 laboratory strains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d33ce4fb865fdb241b995d666f89a1
https://doi.org/10.1128/aac.00759-09
https://doi.org/10.1128/aac.00759-09
Autor:
Rawal Jaiessh, Amy Randall, Tram T. Tran, Fiona M. Adam, Daniel Siddle, Iain Gardner, Tanya Parkinson, Manos Perros, David R. Fenwick, Christopher Pickford, Juin Fok-Seang, Charles E. Mowbray, David Howard Williams, Donald Stuart Middleton, Hannah Vuong, Peter T. Stephenson, Michelle Y. Platts, Duncan Hay
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5246-5249
A series of piperazine derivatives were designed and synthesised as gp120-CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by compounds 9 and 28. The rat pharmacokinetic and antiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3a4d25958155d25e9e2f74217f4f79
https://doi.org/10.1016/j.bmcl.2009.06.080
https://doi.org/10.1016/j.bmcl.2009.06.080
Publikováno v:
European Journal of Neuroscience. 10:2400-2415
Repair of demyelination in the CNS requires that oligodendrocyte precursors (OPs) migrate, divide and then myelinate. Repair of axon damage requires axonal regeneration. Limited remyelination and axon regeneration occurs soon after injury, but usuall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db9339e26206971cfa74ad66c800e806
https://doi.org/10.1046/j.1460-9568.1998.00251.x
https://doi.org/10.1046/j.1460-9568.1998.00251.x
Autor:
John H. Rogers, Elizabeth M. Muir, Elizabeth Housden, James W. Fawcett, L.C. Smith-Thomas, J.-S. Du, Juin Fok-Seang
Publikováno v:
Glia. 23:24-34
The ability of cells to migrate through tissues depends on their production of a variety of proteases, and the same may be true of growth cones. Urokinase (plasminogen activator) regulates much of the extracellular proteolytic activity, by activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c2a297180a60e9e900fdefb246f98dc
https://doi.org/10.1002/(sici)1098-1136(199805)23:1<24::aid-glia3>3.0.co
https://doi.org/10.1002/(sici)1098-1136(199805)23:1<24::aid-glia3>3.0.co
Autor:
Juin Fok-Seang, Robert H. Miller
Publikováno v:
The Journal of Neuroscience. 12:2751-2764
Cultures of newborn rat spinal cord contain multiple types of astrocytes. By using a combination of cultures enriched for glial precursors and clonal analysis, we have identified a particular astrocyte precursor that gives rise to morphologically dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be20f2325d59cd8827d58b23fdf2b92
https://doi.org/10.1523/jneurosci.12-07-02751.1992
https://doi.org/10.1523/jneurosci.12-07-02751.1992
Autor:
Jaiessh Rawal, David Howard Williams, Donald Stuart Middleton, Michelle Y. Platts, Juin Fok-Seang, Manos Perros, Frederick Calo, Duncan Hay, Christopher Pickford, David R. Fenwick, Tram T. Tran, Hannah Vuong, Fiona M. Adam, Iain Gardner, Tanya Parkinson, Peter T. Stephenson, Amy Randall
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(17)
The synthesis and structure-activity relationship of a series of novel gp120-CD4 inhibitors are described. Pharmacokinetic studies and antiviral spectrum assessment of lead compounds led to the identification of compound 36, a potent gp120-CD4 inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0315d777c77dc2ffe5cf5ff5806e52ce
https://pubmed.ncbi.nlm.nih.gov/19632839
https://pubmed.ncbi.nlm.nih.gov/19632839