Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Juili Dilip Shelke"'
Autor:
Wei Liu, Naoki Iwamoto, Subramanian Marappan, Khoa Luu, Snehlata Tripathi, Erin Purcell-Estabrook, Juili Dilip Shelke, Himali Shah, Anthony Lamattina, Qianli Pan, Brett Schrand, Frank Favaloro, Mugdha Bedekar, Arindom Chatterjee, Jigar Desai, Tomomi Kawamoto, Genliang Lu, Jake Metterville, Milinda Samaraweera, Priyanka Shiva Prakasha, Hailin Yang, Yuan Yin, Hui Yu, Paloma H Giangrande, Michael Byrne, Pachamuthu Kandasamy, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 51:4126-4147
Herein, we report the systematic investigation of stereopure phosphorothioate (PS) and phosphoryl guanidine (PN) linkages on siRNA-mediated silencing. The incorporation of appropriately positioned and configured stereopure PS and PN linkages to N-ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f52fce2dc6c2c20d3fb621264918bd6b
https://doi.org/10.1093/nar/gkad268
https://doi.org/10.1093/nar/gkad268
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
Autor:
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 50:5401-5423
Attaining sufficient tissue exposure at the site of action to achieve the desired pharmacodynamic effect on a target is an important determinant for any drug discovery program, and this can be particularly challenging for oligonucleotides in deep tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd2c8b0ca0bc373823740210c986ec
https://doi.org/10.1093/nar/gkac037
https://doi.org/10.1093/nar/gkac037
Autor:
Pachamuthu Kandasamy, Ann Fiegen Durbin, Michael Byrne, Robert H. Brown, Jean-Cosme Dodart, Yuan Yin, Kenneth Longo, Amy Donner, Fangjun Liu, Xiao Shelley Hu, Naoki Iwamoto, Juili Dilip Shelke, Maurine Braun, Chandra Vargeese, Jörg Ruschel, Hailin Yang, Helene Tran, Shaunna Berkovitch, Yuanjing Liu, Zhong Zhong, Hyun Gyung Jang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
A large G4C2-repeat expansion in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Neuronal degeneration associated with this expansion arises from a loss of C9orf72 protein, the accumu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5a4da0d93fe4e3773026ba3df968a1
https://doaj.org/article/c67a2cf526554819ac5be15eaecb07de
https://doaj.org/article/c67a2cf526554819ac5be15eaecb07de
Autor:
Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam, Naoki Iwamoto, Jayakanthan Kumarasamy, Gopal R Bommineni, Adam Bezigian, Onanong Chivatakarn, David C D Butler, Michael Byrne, Katarzyna Chwalenia, Kay E Davies, Jigar Desai, Juili Dilip Shelke, Ann F Durbin, Ruth Ellerington, Ben Edwards, Jack Godfrey, Andrew Hoss, Fangjun Liu, Kenneth Longo, Genliang Lu, Subramanian Marappan, Jacopo Oieni, Ik-Hyeon Paik, Erin Purcell Estabrook, Chikdu Shivalila, Maeve Tischbein, Tomomi Kawamoto, Carlo Rinaldi, Joana Rajão-Saraiva, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Cong Zhou, Jason Zhang, Luciano Apponi, Matthew J A Wood, Chandra Vargeese
Publikováno v:
Nucleic acids research. 50(10)
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an advance for the splice-switching field, current SSO chemistries have shown limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4563bb9a20823ec7e04b7dd2e362f73
https://pubmed.ncbi.nlm.nih.gov/35061895
https://pubmed.ncbi.nlm.nih.gov/35061895
Autor:
Michael, Byrne, Vinod, Vathipadiekal, Luciano, Apponi, Naoki, Iwamoto, Pachamuthu, Kandasamy, Kenneth, Longo, Fangjun, Liu, Richard, Looby, Lauren, Norwood, Anee, Shah, Juili Dilip, Shelke, Chikdu, Shivalila, Hailin, Yang, Yuan, Yin, Lankai, Guo, Keith, Bowman, Chandra, Vargeese
Publikováno v:
Translational Vision Science & Technology
Purpose Antisense oligonucleotides have been under investigation as potential therapeutics for many diseases, including inherited retinal diseases. Chemical modifications, such as chiral phosphorothioate (PS) backbone modification, are often used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::575c2acf4b12d20dd0ba7bd1766360f8
https://pubmed.ncbi.nlm.nih.gov/33510962
https://pubmed.ncbi.nlm.nih.gov/33510962
Autor:
Juili Dilip Shelke, Michael Byrne, Hailin Yang, Pachamuthu Kandasamy, Keith Bowman, Lauren Norwood, Luciano H. Apponi, Kenneth Longo, Yuan Yin, Lankai Guo, Anee Shah, Chandra Vargeese, Vinod Vathipadiekal, Naoki Iwamoto, Chikdu Shakti Shivalila, Fangjun Liu, Richard Looby
Publikováno v:
Translational Vision Science & Technology. 10:23
Purpose Antisense oligonucleotides have been under investigation as potential therapeutics for many diseases, including inherited retinal diseases. Chemical modifications, such as chiral phosphorothioate (PS) backbone modification, are often used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a72b3661eeb196a32be0e8299282af1f
https://doi.org/10.1167/tvst.10.1.23
https://doi.org/10.1167/tvst.10.1.23