Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Jui-Hua Hsieh"'
Autor:
Anna Kreutz, Oluwakemi B. Oyetade, Xiaoqing Chang, Jui-Hua Hsieh, Mamta Behl, David G. Allen, Nicole C. Kleinstreuer, Helena T. Hogberg
Publikováno v:
Toxics, Vol 12, Iss 6, p 437 (2024)
Organophosphorus flame retardants (OPFRs) are abundant and persistent in the environment but have limited toxicity information. Their similarity in structure to organophosphate pesticides presents great concern for developmental neurotoxicity (DNT).
Externí odkaz:
https://doaj.org/article/b9c9cf0a09ab4395abede8e2b28ea39d
Autor:
Jon T. Hamm, Jui-Hua Hsieh, Georgia K. Roberts, Bradley Collins, Jenni Gorospe, Barney Sparrow, Nigel J. Walker, Lisa Truong, Robyn L. Tanguay, Sylvia Dyballa, Rafael Miñana, Valentina Schiavone, Javier Terriente, Andrea Weiner, Arantza Muriana, Celia Quevedo, Kristen R. Ryan
Publikováno v:
Toxics, Vol 12, Iss 1, p 93 (2024)
Embryonic zebrafish represent a useful test system to screen substances for their ability to perturb development. The exposure scenarios, endpoints captured, and data analysis vary among the laboratories who conduct screening. A lack of harmonization
Externí odkaz:
https://doaj.org/article/fe04f956da7a498393268a3e24973ccf
Corrigendum: Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis
Autor:
Parker Combs, Jeremy Erickson, Jui-Hua Hsieh, Kai Guo, Sue Nolte, Charles Schmitt, Scott Auerbach, Junguk Hur
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Externí odkaz:
https://doaj.org/article/230a2ee041984fc198b3d0cdd4b6ab9e
Autor:
Parker Combs, Jeremy Erickson, Jui-Hua Hsieh, Kai Guo, Sue Nolte, Charles Schmitt, Scott Auerbach, Junguk Hur
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Inference of toxicological and mechanistic properties of untested chemicals through structural or biological similarity is a commonly employed approach for initial chemical characterization and hypothesis generation. We previously developed a web-bas
Externí odkaz:
https://doaj.org/article/eb9bf185c5fc46588c1f8a599061c2d9
Autor:
Tony Eight Lin, Li-Chin Sung, Min-Wu Chao, Min Li, Jia-Huei Zheng, Tzu-Ying Sung, Jui-Hua Hsieh, Chia-Ron Yang, Hsueh-Yun Lee, Er-Chieh Cho, Kai-Cheng Hsu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 226-235 (2022)
Bruton tyrosine kinase (BTK) is linked to multiple signalling pathways that regulate cellular survival, activation, and proliferation. A covalent BTK inhibitor has shown favourable outcomes for treating B cell malignant leukaemia. However, covalent i
Externí odkaz:
https://doaj.org/article/4eee7f20c593416abeb5853c9de04c92
Autor:
Danielle Ireland, Siqi Zhang, Veronica Bochenek, Jui-Hua Hsieh, Christina Rabeler, Zane Meyer, Eva-Maria S. Collins
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Organophosphorus pesticides (OPs) are a chemically diverse class of commonly used insecticides. Epidemiological studies suggest that low dose chronic prenatal and infant exposures can lead to life-long neurological damage and behavioral disorders. Wh
Externí odkaz:
https://doaj.org/article/fb348face9264fa29985af3d23d4419d
Autor:
Jui-Hua Hsieh, Sue Nolte, Jon T. Hamm, Zicong Wang, Georgia K. Roberts, Charles P. Schmitt, Kristen R. Ryan
Publikováno v:
Toxics, Vol 11, Iss 5, p 407 (2023)
The embryonic zebrafish is a useful vertebrate model for assessing the effects of substances on growth and development. However, cross-laboratory developmental toxicity outcomes can vary and reported developmental defects in zebrafish may not be dire
Externí odkaz:
https://doaj.org/article/4a0478dfadd64bb1aa56137e9a3f5c9e
Autor:
Tony Eight Lin, Chia-Ron Yang, Ching-Hsuan Chou, Jui-Yi Hsu, Min-Wu Chao, Tzu-Ying Sung, Jui-Hua Hsieh, Wei-Jan Huang, Kai-Cheng Hsu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112459- (2022)
Chronic inflammation is an underlying cause in a number of diseases. Cyclin-dependent kinase 8 (CDK8) has been implicated as an inflammatory mediator, indicating its potential as an anti-inflammatory target. Herein, we performed structure-based virtu
Externí odkaz:
https://doaj.org/article/0571fe428d584aff829c19f8da7aaa05
Autor:
Tony Eight Lin, Min-Wu Chao, Wei-Chun HuangFu, Huang-Ju Tu, Zhao-Xiang Peng, Chih-Jou Su, Tzu-Ying Sung, Jui-Hua Hsieh, Cheng-Chung Lee, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112580- (2022)
The dysregulation of DYRK1A is implicated in many diseases such as cancer, diabetes, and neurodegenerative diseases. Alzheimer’s disease is one of the most common neurodegenerative disease and has elevated interest in DYRK1A research. Overexpressio
Externí odkaz:
https://doaj.org/article/bde6aaca1032477f872fda9997782694
Autor:
Kai-Cheng Hsu, Chang-Yi Liu, Tony Eight Lin, Jui-Hua Hsieh, Tzu-Ying Sung, Hui-Ju Tseng, Jinn-Moon Yang, Wei-Jan Huang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Histone deacetylases (HDAC) contain eighteen isoforms that can be divided into four classes. Of these isoform enzymes, class IIa (containing HDAC4, 5, 7 and 9) target unique substrates, some of which are client proteins associated with epige
Externí odkaz:
https://doaj.org/article/7b99dbc22d7541d3950827cebd4867ae