Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jui-Heng Tseng"'
Autor:
Miles R. Bryan III, Xu Tian, Jui-Heng Tseng, Baggio A. Evangelista, Joey V. Ragusa, Audra F. Bryan, Winifred Trotman, David Irwin, Todd J. Cohen
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Tauopathies, including Alzheimer’s disease (AD), are a class of neurodegenerative diseases characterized by the presence of insoluble tau inclusions. Tau phosphorylation has traditionally been viewed as the dominant post-translational modi
Externí odkaz:
https://doaj.org/article/a224761b89a941c684570125212d6515
Autor:
Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V. Riddick, Michelle S. Itano, Ashutosh Tripathy, Sheryl S. Moy, Virginia M. Y. Lee, John Q. Trojanowski, David J. Irwin, Todd J. Cohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
HDAC6 is a tau deacetylase and acetylation of tau inhibits its function and promotes aggregation. Here the authors show that HDAC6 protects against tau accumulation in a mouse model of tauopathy.
Externí odkaz:
https://doaj.org/article/61ab6286279144ac8d59a59cc0805267
Autor:
Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101255- (2020)
Summary: The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species
Externí odkaz:
https://doaj.org/article/4d3bd9a5d99a43c1a2f2a65407b70fe6
Autor:
Jui-Heng Tseng, Ling Xie, Sheng Song, Youmei Xie, Lauren Allen, Deepa Ajit, Jau-Shyong Hong, Xian Chen, Rick B. Meeker, Todd J. Cohen
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2169-2183 (2017)
The initiating events that promote tau mislocalization and pathology in Alzheimer’s disease (AD) are not well defined, partly because of the lack of endogenous models that recapitulate tau dysfunction. We exposed wild-type neurons to a neuroinflamm
Externí odkaz:
https://doaj.org/article/1665a8b11919450b82d0f39837a40b91
Autor:
Ashutosh Tripathy, Deepa Ajit, Natallia V. Riddick, John Q. Trojanowski, Michelle S. Itano, Sheryl S. Moy, Hanna Trzeciakiewicz, Todd J. Cohen, Zarin Tabassum, Youjun Chen, Claire Peterson, Rebecca Lobrovich, Jui-Heng Tseng, Aditi Ajit, Virginia M.-Y. Lee, David J. Irwin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Tauopathies including Alzheimer’s disease (AD) are marked by the accumulation of aberrantly modified tau proteins. Acetylated tau, in particular, has recently been implicated in neurodegeneration and cognitive decline. HDAC6 reversibly regulates ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd10a6c5e8f3d302f740aa43d104675
http://link.springer.com/article/10.1038/s41467-020-19317-4
http://link.springer.com/article/10.1038/s41467-020-19317-4
Autor:
Zarin Tabassum, Jui-Heng Tseng, Camryn Isemann, Xu Tian, Youjun Chen, Laura E. Herring, Todd J. Cohen
Publikováno v:
The Journal of biological chemistry. 298(6)
The posttranslational regulation of the neuronal proteome is critical for brain homeostasis but becomes dysregulated in the aged or diseased brain, in which abnormal posttranslational modifications (PTMs) are frequently observed. While the full exten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b9a6acbe57878d9f7b3ef50b5e8206
https://pubmed.ncbi.nlm.nih.gov/35469920
https://pubmed.ncbi.nlm.nih.gov/35469920
Autor:
Baggio A Evangelista, Kathleen S. M. Reed, Aimee E Cruikshank, Ivana Y Quiroga, Rick B. Meeker, Douglas H. Phanstiel, Sarah S. Cohen, Jui-Heng Tseng, Hyejung Won, Joey V Ragusa, Todd J. Cohen, Marielle L Bond
Alzheimers disease (AD) is a progressive neurodegenerative disease that impacts nearly 400 million people worldwide. The accumulation of amyloid beta (A{beta}) in the brain has historically been associated with AD, and recent evidence suggests that n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12b2fdac644b4c357232219b7c821ebb
https://doi.org/10.1101/2021.09.14.460110
https://doi.org/10.1101/2021.09.14.460110
Autor:
Zarin Tabassum1, Jui-Heng Tseng1, Isemann, Camryn1, Xu Tian1, Youjun Chen1, Herring, Laura E.2, Cohen, Todd J.1,3 toddcohen@neurology.unc.edu
Publikováno v:
Journal of Biological Chemistry. Jun2022, Vol. 298 Issue 6, p1-14. 14p.
Autor:
Rick B. Meeker, Heba Al Housseiny, Connor M. Wander, Yen-Yu Ian Shih, Sheng Song, Jui-Heng Tseng, Aditi Ajit, Juan Song, David J. Irwin, Todd J. Cohen, Dalton S. Tart, Rebecca Lobrovich
Publikováno v:
iScience
iScience, Vol 23, Iss 7, Pp 101255-(2020)
iScience, Vol 23, Iss 7, Pp 101255-(2020)
Summary The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba053b2be352a444a5aeb99745cbd81
http://europepmc.org/articles/PMC7322077
http://europepmc.org/articles/PMC7322077