Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Juho Vuononvirta"'
Autor:
Claire Vinel, Gabriel Rosser, Loredana Guglielmi, Myrianni Constantinou, Nicola Pomella, Xinyu Zhang, James R. Boot, Tania A. Jones, Thomas O. Millner, Anaelle A. Dumas, Vardhman Rakyan, Jeremy Rees, Jamie L. Thompson, Juho Vuononvirta, Suchita Nadkarni, Tedani El Assan, Natasha Aley, Yung-Yao Lin, Pentao Liu, Sven Nelander, Denise Sheer, Catherine L. R. Merry, Federica Marelli-Berg, Sebastian Brandner, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the disco
Externí odkaz:
https://doaj.org/article/eef727b592d24a7697303fa96e18e608
Autor:
Kenneth C. P. Cheung, Silvia Fanti, Claudio Mauro, Guosu Wang, Anitha S. Nair, Hongmei Fu, Silvia Angeletti, Silvia Spoto, Marta Fogolari, Francesco Romano, Dunja Aksentijevic, Weiwei Liu, Baiying Li, Lixin Cheng, Liwen Jiang, Juho Vuononvirta, Thanushiyan R. Poobalasingam, David M. Smith, Massimo Ciccozzi, Egle Solito, Federica M. Marelli-Berg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on en
Externí odkaz:
https://doaj.org/article/df928ac93a0a4597a8951f70e8733d1b
Autor:
Goda Juzenaite, Judith Secklehner, Juho Vuononvirta, Yoseph Helbawi, John B. G. Mackey, Charlotte Dean, James A. Harker, Leo M. Carlin, Sara Rankin, Katia De Filippo
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The rapid response of neutrophils throughout the body to a systemic challenge is a critical first step in resolution of bacterial infection such as Escherichia coli (E. coli). Here we delineated the dynamics of this response, revealing novel insights
Externí odkaz:
https://doaj.org/article/67efe035c82742a48b93c25118ed42a5
Autor:
Sari Törmänen, Matti Korppi, Johanna Teräsjärvi, Juho Vuononvirta, Petri Koponen, Merja Helminen, Qiushui He, Kirsi Nuolivirta
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Toll-like receptors (TLRs) recognise microbes that contribute to the severity of bronchiolitis and the subsequent risk of asthma. We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs
Externí odkaz:
https://doaj.org/article/ccd67b4332b1487e93909ba9c7e36725
Autor:
Eero Lauhkonen, Petri Koponen, Juho Vuononvirta, Johanna Teräsjärvi, Kirsi Nuolivirta, Jyri O Toikka, Merja Helminen, Qiushui He, Matti Korppi
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146526 (2016)
AIM:Toll-like receptors (TLR) play a crucial role in innate immunity, protecting the host from pathogens such as viruses. Genetic variations in TLRs have been associated with the severity of viral bronchiolitis in infancy and with the later occurrenc
Externí odkaz:
https://doaj.org/article/c291d2f5baef468a8220229a7c90ea03
Autor:
Eero Lauhkonen, Petri Koponen, Johanna Teräsjärvi, Kirsi Gröndahl-Yli-Hannuksela, Juho Vuononvirta, Kirsi Nuolivirta, Jyri O Toikka, Merja Helminen, Qiushui He, Matti Korppi
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140799 (2015)
Interleukin-10 (IL-10) has been associated with wheezing and asthma in children and the genetic variation of the IL-10 cytokine production may be linked to post-bronchiolitis lung function. We used impulse oscillometry (IOS) to evaluate the associati
Externí odkaz:
https://doaj.org/article/f2c910c0e7db43e6996b63fae44506a2
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88919 (2014)
BACKGROUND: Mannose-binding lectin (MBL) is one of the key molecules in innate immunity and its role in human vaccine responses is poorly known. This study aimed to investigate the possible association of MBL polymorphisms with antibody production af
Externí odkaz:
https://doaj.org/article/45448595d3a2473882ef58f5c3ed8e8e
Autor:
Juho Vuononvirta, Laura Toivonen, Kirsi Gröndahl-Yli-Hannuksela, Alex-Mikael Barkoff, Laura Lindholm, Jussi Mertsola, Ville Peltola, Qiushui He
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26198 (2011)
BACKGROUND: Human nasopharynx is often colonized by potentially pathogenic bacteria. Gene polymorphisms in mannose-binding lectin (MBL), toll-like receptor (TLR) 2 and TLR4 have been reported. The present study aimed to investigate possible associati
Externí odkaz:
https://doaj.org/article/5391767151c34565a2342028fdec7ff5
Autor:
James R. Boot, Denise Sheer, Vardhman K. Rakyan, Catherine L.R. Merry, Claire Vinel, Sebastian Brandner, Sven Nelander, Yung-Yao Lin, Suchita Nadkarni, Tedani El Assan, Juho Vuononvirta, Thomas O Millner, Federica M. Marelli-Berg, Myrianni Constantinou, Loredana Guglielmi, Jamie L. Thompson, Xinyu Zhang, Gabriel Rosser, Tania A. Jones, Pentao Liu, Nicola Pomella, Anaelle A. Dumas, Jeremy Rees, Natasha Aley, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develo
Autor:
Lamya Yamani, Frances R. Balkwill, Federica M. Marelli-Berg, Juho Vuononvirta, Melania Capasso, Eleanor J. Ward, Suchita Nadkarni, Maryam Jangani
Publikováno v:
Journal of leukocyte biology 111(5), 967-980 (2022). doi:10.1002/JLB.1A0920-588R
Monocyte migration to the sites of inflammation and maturation into macrophages are key steps for their immune effector function. Here, we show that mechanistic target of rapamycin complex 2 (mTORC2)-dependent Akt activation is instrumental for metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c37bac8cd8d674c7b85b94c49a2a57
https://pub.dzne.de/record/162927
https://pub.dzne.de/record/162927