Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Juho Rousu"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background In last two decades, the use of high-throughput sequencing technologies has accelerated the pace of discovery of proteins. However, due to the time and resource limitations of rigorous experimental functional characterization, the
Externí odkaz:
https://doaj.org/article/a5dcf5f0ad87463f95bb0a879529be25
Autor:
Maryam Astero, Juho Rousu
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Accurate atom mapping, which establishes correspondences between atoms in reactants and products, is a crucial step in analyzing chemical reactions. In this paper, we present a novel end-to-end approach that formulates the atom mapping probl
Externí odkaz:
https://doaj.org/article/ada8551207434d2cac7cfbd5c0c03265
Publikováno v:
Advanced Science, Vol 11, Iss 8, Pp n/a-n/a (2024)
Abstract Aerosol particles found in the atmosphere affect the climate and worsen air quality. To mitigate these adverse impacts, aerosol particle formation and aerosol chemistry in the atmosphere need to be better mapped out and understood. Currently
Externí odkaz:
https://doaj.org/article/557948cf39a34e60841aba012e829d8a
Autor:
Weikaixin Kong, Gianmarco Midena, Yingjia Chen, Paschalis Athanasiadis, Tianduanyi Wang, Juho Rousu, Liye He, Tero Aittokallio
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2807-2814 (2022)
Synergistic effects between drugs are rare and highly context-dependent and patient-specific. Hence, there is a need to develop novel approaches to stratify patients for optimal therapy regimens, especially in the context of personalized design of co
Externí odkaz:
https://doaj.org/article/175a067dc4514c28b5498d1175b594cd
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010177 (2022)
Engineered microbial cells present a sustainable alternative to fossil-based synthesis of chemicals and fuels. Cellular synthesis routes are readily assembled and introduced into microbial strains using state-of-the-art synthetic biology tools. Howev
Externí odkaz:
https://doaj.org/article/829fbf0e0b62409195b258f0eefcd7d5
Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects
Autor:
Heli Julkunen, Anna Cichonska, Prson Gautam, Sandor Szedmak, Jane Douat, Tapio Pahikkala, Tero Aittokallio, Juho Rousu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Combinatorial treatments have become a standard of care for various complex diseases including cancers. Here, the authors show that combinatorial responses of two anticancer drugs can be accurately predicted using factorization machines trained on la
Externí odkaz:
https://doaj.org/article/1dbe0a68db6948d0bdbef3a4f57cf4b3
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3819-3832 (2020)
While high-throughput drug screening offers possibilities to profile phenotypic responses of hundreds of compounds, elucidation of the cell context-specific mechanisms of drug action requires additional analyses. To that end, we developed a computati
Externí odkaz:
https://doaj.org/article/25a61671e8804d9591c69081345c5309
Autor:
Grímur Hjörleifsson Eldjárn, Andrew Ramsay, Justin J J van der Hooft, Katherine R Duncan, Sylvia Soldatou, Juho Rousu, Rónán Daly, Joe Wandy, Simon Rogers
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008920 (2021)
Specialised metabolites from microbial sources are well-known for their wide range of biomedical applications, particularly as antibiotics. When mining paired genomic and metabolomic data sets for novel specialised metabolites, establishing links bet
Externí odkaz:
https://doaj.org/article/89b6d5a70ae74450a811bae11ac64a60
Autor:
Emma L. Schymanski, Christoph Ruttkies, Martin Krauss, Céline Brouard, Tobias Kind, Kai Dührkop, Felicity Allen, Arpana Vaniya, Dries Verdegem, Sebastian Böcker, Juho Rousu, Huibin Shen, Hiroshi Tsugawa, Tanvir Sajed, Oliver Fiehn, Bart Ghesquière, Steffen Neumann
Publikováno v:
Journal of Cheminformatics, Vol 9, Iss 1, Pp 1-21 (2017)
Abstract Background The fourth round of the Critical Assessment of Small Molecule Identification (CASMI) Contest ( www.casmi-contest.org ) was held in 2016, with two new categories for automated methods. This article covers the 208 challenges in Cate
Externí odkaz:
https://doaj.org/article/013056657b734f69b3d71c7aa087fc60
Autor:
Anna Cichonska, Balaguru Ravikumar, Elina Parri, Sanna Timonen, Tapio Pahikkala, Antti Airola, Krister Wennerberg, Juho Rousu, Tero Aittokallio
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 8, p e1005678 (2017)
Due to relatively high costs and labor required for experimental profiling of the full target space of chemical compounds, various machine learning models have been proposed as cost-effective means to advance this process in terms of predicting the m
Externí odkaz:
https://doaj.org/article/7279e5f8bd5b43b087551e17292e5595