Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Juho Pirhonen"'
Autor:
Burcin Gungor, Lauri Vanharanta, Maarit Hölttä-Vuori, Juho Pirhonen, Nikolaj H.T. Petersen, Silvia Gramolelli, Päivi M. Ojala, Thomas Kirkegaard, Elina Ikonen
Publikováno v:
Molecular Metabolism, Vol 28, Iss , Pp 135-143 (2019)
Objective: Heat Shock Proteins (HSPs) maintain cellular homeostasis under stress. HSP70 represents a major stress-inducible family member and has been identified as a druggable target in inherited cholesterol-sphingolipid storage diseases. We investi
Externí odkaz:
https://doaj.org/article/2ed7880320f64daea1d5fa9a9ec7e58a
Autor:
Simon G. Pfisterer, Gergana Gateva, Peter Horvath, Juho Pirhonen, Veijo T. Salo, Leena Karhinen, Markku Varjosalo, Samppa J. Ryhänen, Pekka Lappalainen, Elina Ikonen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Lipid droplets (LDs) are cellular organelles dedicated to triacylglycerol storage that can undergo fusion and dissociation events. Here the authors show that formin-like 1-dependent acto-myosin assembly on LDs facilitates their dissociation and, as a
Externí odkaz:
https://doaj.org/article/ed431a9166504d47adae4b3f6abb8d16
Autor:
Juho Pirhonen, Johanna Arola, Sanja Sädevirta, Panu Luukkonen, Sanna-Maria Karppinen, Taina Pihlajaniemi, Antti Isomäki, Mika Hukkanen, Hannele Yki-Järvinen, Elina Ikonen
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147804 (2016)
BACKGROUND AND AIMS:Early detection of fibrosis is important in identifying individuals at risk for advanced liver disease in non-alcoholic fatty liver disease (NAFLD). We tested whether second-harmonic generation (SHG) and coherent anti-Stokes Raman
Externí odkaz:
https://doaj.org/article/5b05bc2430d14e87b34a2c9b26d39c3c
Autor:
Elina Ikonen, Pauli Puolakkainen, György Markó-Varga, Peter Horvath, Johan Malm, Melinda Rezeli, Jeovanis Gil, Caj Haglund, Hanna Seppänen, Johan Peränen, Maarit Hölttä, Mária Kovács, Ede Migh, Yonghyo Kim, Jaana Hagström, Ábel Szkalisity, Juho Pirhonen
Supplementary Data from Lipid Metabolic Reprogramming Extends beyond Histologic Tumor Demarcations in Operable Human Pancreatic Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4904f6adcd6ea8991e71326ddf13c3
https://doi.org/10.1158/0008-5472.22432620
https://doi.org/10.1158/0008-5472.22432620
Autor:
Elina Ikonen, Pauli Puolakkainen, György Markó-Varga, Peter Horvath, Johan Malm, Melinda Rezeli, Jeovanis Gil, Caj Haglund, Hanna Seppänen, Johan Peränen, Maarit Hölttä, Mária Kovács, Ede Migh, Yonghyo Kim, Jaana Hagström, Ábel Szkalisity, Juho Pirhonen
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies and potentially curable only with radical surgical resection at early stages. The tumor microenvironment has been shown to be central to the development and progression of PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2561d846fa068c6fdd08ce0f6dac360a
https://doi.org/10.1158/0008-5472.c.6514191
https://doi.org/10.1158/0008-5472.c.6514191
Autor:
Juho Pirhonen, Ábel Szkalisity, Jaana Hagström, Yonghyo Kim, Ede Migh, Mária Kovács, Maarit Hölttä, Johan Peränen, Hanna Seppänen, Caj Haglund, Jeovanis Gil, Melinda Rezeli, Johan Malm, Peter Horvath, György Markó-Varga, Pauli Puolakkainen, Elina Ikonen
Publikováno v:
Cancer research. 82(21)
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies and potentially curable only with radical surgical resection at early stages. The tumor microenvironment has been shown to be central to the development and progression of PD
Autor:
Henriikka Kentala, Robert Andrews, Zoltán Pataj, Vesa M. Olkkonen, Eija Jokitalo, Juho Pirhonen, Silke Matysik, Leena Karhinen, Eeva Jääskeläinen, Leena Meriläinen, Shiqian Li, Annika Koponen, Helena Vihinen, You Zhou, Elina Ikonen, Annukka M. Kivelä, Gerhard Liebisch
ORP2 is a ubiquitously expressed OSBP-related protein previously implicated in endoplasmic reticulum (ER)lipid droplet (LD) contacts, triacylglycerol (TG) metabolism, cholesterol transport, adrenocortical steroidogenesis, and actin-dependent cell dyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b303677a08f933f22ed4019fde9404fe
http://hdl.handle.net/10138/250548
http://hdl.handle.net/10138/250548
Autor:
Pekka Lappalainen, Samppa J. Ryhänen, Leena Karhinen, Elina Ikonen, Markku Varjosalo, Peter Horvath, Simon G. Pfisterer, Juho Pirhonen, Veijo T. Salo, Gergana Gateva
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications
Lipid droplets (LDs) are cellular organelles specialized in triacylglycerol (TG) storage undergoing homotypic clustering and fusion. In non-adipocytic cells with numerous LDs this is balanced by poorly understood droplet dissociation mechanisms. We i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e072cb63a3ae3c81579e819f0ac2e554
http://hdl.handle.net/10138/183452
http://hdl.handle.net/10138/183452
Autor:
Panu K. Luukkonen, Elina Ikonen, Sanja Sädevirta, Juho Pirhonen, Sanna-Maria Karppinen, Antti Isomäki, Johanna Arola, Hannele Yki-Järvinen, Mika Hukkanen, Taina Pihlajaniemi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0147804 (2016)
PLoS ONE, Vol 11, Iss 1, p e0147804 (2016)
Background and Aims Early detection of fibrosis is important in identifying individuals at risk for advanced liver disease in non-alcoholic fatty liver disease (NAFLD). We tested whether second-harmonic generation (SHG) and coherent anti-Stokes Raman
Autor:
Antti Isomäki, Sanja Sädevirta, Hannele Yki-Järvinen, Taina Pihlajaniemi, Juho Pirhonen, Panu K. Luukkonen, Sanna-Maria Karppinen, Elina Ikonen, Mika Hukkanen, Johanna Arola
Publikováno v:
Atherosclerosis. 252:e154