Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Juho Hokkanen"'
Publikováno v:
Frontiers in Pharmacology, Vol 1 (2010)
Liquid chromatography-mass spectrometry (LC/MS) with generic gradient elution for a large number of chemically different compounds is a common approach in drug development, used to acquire a large amount of data in a short time frame for drug candida
Externí odkaz:
https://doaj.org/article/5d7b104c8e164552bc435f534e53ff33
Autor:
Juho Hokkanen, Maxi Heyner, Juana Díez, Valtteri Rinne, Mark Brönstrup, Kirsten Harmrolfs, Yuichi Sugiyama, Katharina Rox, Rolf Müller, Andrea Kröger, Jana Krull, Gemma Perez Vilaro
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] While a drug treatment is unavailable, the global incidence of Dengue virus (DENV) infections and its associated severe manifestations continues to rise. We report the construction of the first physiologically based pharmacokinetic/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f4ae480e5acb049a093789509650a1
https://doi.org/10.1021/acsptsci.1c00078
https://doi.org/10.1021/acsptsci.1c00078
Autor:
Juho Hokkanen, Olayemi M. Adegbolagun, Titilayo O. Fakeye, Ari Tolonen, Sharon I. Igbinoba, Marena Kajula, Johnson Segun Showande
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 30
Background Hibiscus sabdariffa beverage (HSB) is widely consumed as a medicinal herb and sometimes used concomitantly with drugs. This study evaluated the in vitro inhibitory potential of the aqueous extract of H. sabdariffa calyces (AEHS) on selecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c638238b4391db6051320e04ce03064
https://doi.org/10.1515/jbcpp-2018-0206
https://doi.org/10.1515/jbcpp-2018-0206
Autor:
Hans-Georg Sahl, Pere Picart, Ari Turpeinen, Marena Kajula, Janne A. Ihalainen, Mysore V. Tejesvi, Anna Maria Pirttilä, Sampo Mattila, Ari Tolonen, Juho Hokkanen, Joshua M. Ward, Heikki Häkkänen
Publikováno v:
Journal of Natural Products. 79:685-690
Three new epithiodiketopiperazine natural products [outovirin A (1), outovirin B (2), and outovirin C (3)] resembling the antifungal natural product gliovirin have been identified in extracts of Penicillium raciborskii, an endophytic fungus isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5ad5a95713f1d5c5e4d607594098bd
https://doi.org/10.1021/np500822k
https://doi.org/10.1021/np500822k
Autor:
Juho Hokkanen, John Z. Cao, Tuukka Ihantola, William G. Kaelin, Christopher J. Mariani, Lucy A. Godley, Peppi Koivunen, Tuomas Laukka
Publikováno v:
Journal of Biological Chemistry. 291:4256-4265
The TET enzymes are members of the 2-oxoglutarate-dependent dioxygenase family and comprise three isoenzymes in humans: TETs 1-3. These TETs convert 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) in DNA, and high 5-hmC levels are associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da727247d2008c71843d3873caeb912c
https://doi.org/10.1074/jbc.m115.688762
https://doi.org/10.1074/jbc.m115.688762
Publikováno v:
Food Science & Nutrition, 7(1):44-55
Food Science & Nutrition
Food Science & Nutrition
Background Increasing use of medicinal herbs as nutritional supplements and traditional medicines for the treatment of diabetes, hypertension, hyperlipidemia, and malaria fever with conventional drugs poses possibilities of herb–drug interactions (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302c07650a5664eb27d7850d8454e576
Wiley Online Library
Wiley Online Library
Publikováno v:
Chemical Research in Toxicology. 28:2292-2303
Many carboxylic acid-containing drugs are associated with idiosyncratic drug toxicity (IDT), which may be caused by reactive acyl glucuronide metabolites. The rate of acyl migration has been earlier suggested as a predictor of acyl glucuronide reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29190267585a0a35576e3b27fae00b3d
https://doi.org/10.1021/acs.chemrestox.5b00315
https://doi.org/10.1021/acs.chemrestox.5b00315
Publikováno v:
Journal of Agricultural and Food Chemistry. 57:9437-9447
Phenolic compounds from leaves of lingonberry (Vaccinium vitis-idaea L.), bilberry (Vaccinium myrtillus L.), and the natural hybrid of bilberry and lingonberry (Vaccinium x intermedium Ruthe L., hybrid bilberry) were identified using LC/TOF-MS and LC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad22c7c0ec74ec63f8793edf18196c94
https://doi.org/10.1021/jf9022542
https://doi.org/10.1021/jf9022542
Autor:
Sampo Mattila, Anja Hohtola, Ari Tolonen, Anna Maria Pirttilä, Juho Hokkanen, Janne J. Koskimäki, Laura Jaakola, Marja Suorsa
Publikováno v:
European Journal of Plant Pathology. 125:629-640
Bilberry (Vaccinium myrtillus) represents one of the richest flavonoid sources among plants. Flavonoids play variable, species-dependent roles in plant defences. In bilberry, flavonoid metabolism is activated in response to solar radiation but not ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6904fb602cc9ad2d56e91ca9d169670e
https://doi.org/10.1007/s10658-009-9511-6
https://doi.org/10.1007/s10658-009-9511-6
Publikováno v:
FEBS Journal. 275:4329-4342
Hypericins are biologically active constituents of Hypericum perforatum (St John's wort). It is likely that emodin anthrone, an anthraquinone precursor of hypericins, is biosynthesized via the polyketide pathway by type III polyketide synthase (PKS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d3ac4b9c524a804bc2c3a7b9769f86a
https://doi.org/10.1111/j.1742-4658.2008.06576.x
https://doi.org/10.1111/j.1742-4658.2008.06576.x