Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Juhani Huuskonen"'
Autor:
Risto O. Juvonen, Mira Ahinko, Elmeri M. Jokinen, Juhani Huuskonen, Hannu Raunio, Olli T. Pentikäinen
Publikováno v:
ACS Omega, Vol 6, Iss 17, Pp 11286-11296 (2021)
Externí odkaz:
https://doaj.org/article/d98e760f25234a2f80683f7c9d6217d5
Autor:
Sanna Niinivehmas, Pekka A. Postila, Sanna Rauhamäki, Elangovan Manivannan, Sami Kortet, Mira Ahinko, Pasi Huuskonen, Niina Nyberg, Pasi Koskimies, Sakari Lätti, Elina Multamäki, Risto O. Juvonen, Hannu Raunio, Markku Pasanen, Juhani Huuskonen, Olli T. Pentikäinen
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 743-754 (2018)
A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced ≥62% HS
Externí odkaz:
https://doaj.org/article/ca9ca7ff4f1a4f61961e932f9fb13641
Autor:
Sanna Rauhamäki, Pekka A. Postila, Sanna Niinivehmas, Sami Kortet, Emmi Schildt, Mira Pasanen, Elangovan Manivannan, Mira Ahinko, Pasi Koskimies, Niina Nyberg, Pasi Huuskonen, Elina Multamäki, Markku Pasanen, Risto O. Juvonen, Hannu Raunio, Juhani Huuskonen, Olli T. Pentikäinen
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Accordingly, small-molecule MAO-B inhibitors potentially alleviate the symptoms of dopamine-linked neuropathologies such as depress
Externí odkaz:
https://doaj.org/article/7ce7e89c445b4b708ee76689792f6021
Autor:
Pekka Juhani Huuskonen, Arto
Publikováno v:
Facilities, 2014, Vol. 32, Issue 11/12, pp. 723-738.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/F-11-2012-0092
Autor:
Mira Ahinko, Risto O. Juvonen, Elmeri M. Jokinen, Hannu Raunio, Juhani Huuskonen, Olli T. Pentikäinen
Publikováno v:
ACS Omega, Vol 6, Iss 17, Pp 11286-11296 (2021)
ACS Omega
ACS Omega
Of the three enzymes in the human cytochrome P450 family 1, CYP1A2 is an important enzyme mediating metabolism of xenobiotics including drugs in the liver, while CYP1A1 and CYP1B1 are expressed in extrahepatic tissues. Currently used CYP substrates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9137651e7405633df3c5a11400380b9b
https://doi.org/10.1021/acsomega.1c00123
https://doi.org/10.1021/acsomega.1c00123
Autor:
Hannu Raunio, Juhani Huuskonen, Elmeri M. Jokinen, Risto O. Juvonen, Olli Kärkkäinen, Olli T. Pentikäinen
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 51(11)
CYP2A13 enzyme is expressed in human extrahepatic tissues, while CYP2A6 is a hepatic enzyme. Reactions catalysed by CYP2A13 activate tobacco-specific nitrosamines and some other toxic xenobiotics in lungs.To compare oxidation characteristics and subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bc946c85c4c8b8f03a85bef47c020d
https://pubmed.ncbi.nlm.nih.gov/33703988
https://pubmed.ncbi.nlm.nih.gov/33703988
Autor:
Hannu Raunio, Rabia Jehangir, Moshe Finel, Risto O. Juvonen, Olli Kärkkäinen, Olli T. Pentikäinen, Johanna Troberg, Juhani Huuskonen, Aki T. Heikkinen
Beagle dog is a standard animal model for evaluating nonclinical pharmacokinetics of new drug candidates. Glucuronidation in intestine and liver is an important first-pass drug metabolic pathway, especially for phenolic compounds. This study evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3337c30bac2dd826b1ef2c625fcabd
http://urn.fi/URN:NBN:fi:jyu-201911054726
http://urn.fi/URN:NBN:fi:jyu-201911054726
Autor:
Pekka A. Postila, Elina Multamäki, Sanna Niinivehmas, Markku Pasanen, Juhani Huuskonen, Risto O. Juvonen, Pasi Koskimies, Niina Nyberg, Sakari Lätti, Pasi Huuskonen, Hannu Raunio, Sami Kortet, Olli T. Pentikäinen, Mira Ahinko, Elangovan Manivannan, Sanna Rauhamäki
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 743-754 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 743-754 (2018)
A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-b-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced 62% HSD1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6286a50cf65022396da43b1badcca946
http://juuli.fi/Record/0330858218
http://juuli.fi/Record/0330858218
Cytochrome P450 (CYP) enzymes constitute an essential xenobiotic metabolizing system that regulates the elimination of lipophilic compounds from the body. Convenient and affordable assays for CYP enzymes are important for assessing these metabolic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd69637c049ad752e6342ffdb71cc5f
Autor:
Moshe Finel, Risto O. Juvonen, Juhani Huuskonen, Olli T. Pentikäinen, Sanna Niinivehmas, Johanna Troberg, Sanna Rauhamäki, Aleksanteri Petsalo, Hannu Raunio, Sami Kortet
Intestinal and hepatic glucuronidation by the UDP-glucuronosyltransferases (UGTs) greatly affect the bioavailability of phenolic compounds. UGT1A10 catalyzes glucuronidation reactions in the intestine, but not in the liver. Here, our aim was to devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377ce476f5ec0cc73c7cb09d06309193
http://urn.fi/URN:NBN:fi:jyu-201803051654
http://urn.fi/URN:NBN:fi:jyu-201803051654