Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Juhana M. Hakumäki"'
Publikováno v:
NMR in Biomedicine. 22:272-279
The measurement of water diffusion by diffusion-weighted MRI (DWI) in vivo offers a non-invasive method for assessing tissue responses to anti-cancer therapies. The pathway of cell death after anti-cancer treatment is often apoptosis, which leads to
Autor:
Ari Hinkkanen, Jarmo Wahlfors, Outi Rautsi, Markus Vähä-Koskela, Juhana M. Hakumäki, Thomas Wirth, Tiina Wahlfors, Ann-Marie Määttä, Katja Häkkinen, Linda C. Jansson, Piia Valonen, Kimmo Mäkinen, Riikka Pellinen, Timo Liimatainen
Publikováno v:
International Journal of Cancer. 121:863-870
Semliki Forest virus (SFV) is one of the latest candidates for a virotherapeutic agent against cancer, and recent studies have demonstrated its efficacy in tumor models. In the present study, we examined the antitumor efficacy of an avirulent SFV str
Autor:
Juhana M. Hakumäki, John D. Gearhart, Kimmo K. Lehtimäki, Jacobus F.A. Jansen, Peter C.M. van Zijl, Jeff W.M. Bulte, Michael J. Shamblott
Publikováno v:
Magnetic Resonance in Medicine. 56:666-670
The classification of embryonic and adult stem cells, including their derivatives, is still limited, and often these cells are best defined by their functional properties. Recent gene array studies have yielded contradictory results. Also, very littl
Publikováno v:
FEBS Letters. 580:4746-4750
This letter presents a novel identification and analysis of mobile cholesterol compounds in an experimental glioma model by 1H MRS in vivo. The cholesterol compounds turned out to comprise as much as 17mol% of MRS visible total lipids. The results al
Autor:
Juhana M. Hakumäki, T. Wirth, Teemu O. Ihalainen, Jani K. Raty, Ale Närvänen, E Hamerlynck, Tuulia Huhtala, Seppo Ylä-Herttuala, Timo Liimatainen, Kari Airenne, Maija Vihinen-Ranta
Publikováno v:
Gene Therapy. 13:1440-1446
We describe here a technique for the visualization of viral vector delivery by magnetic resonance imaging (MRI) in vivo. By conjugating avidin-coated baculoviral vectors (Baavi) with biotinylated ultra-small superparamagnetic iron oxide particles (US
Publikováno v:
Magnetic Resonance in Medicine. 55:800-804
Current therapeutic approaches to treat cancer are often hampered by the lack of specificity of the drugs used for therapy. Scavidin, a novel fusion protein expressed on cell membranes, could be utilized for targeting of therapeutic molecules. Scavid
Autor:
Johanna Silvennoinen, Heikki J. Helminen, Miika T. Nieminen, Juhana M. Hakumäki, Jukka S. Jurvelin, Juha Töyräs, Mika M. Hyttinen, Jarno Rieppo
Publikováno v:
Magnetic Resonance in Medicine. 48:640-648
In Gd-DTPA-enhanced T imaging of articular cartilage, the MRI contrast agent with two negative charges is understood to accumulate in tissue inversely to the negative charge of cartilage glycosaminoglycans (GAGs) of proteoglycans (PGs), and this lead
Autor:
Juhana M. Hakumäki, Seppo Ylä-Herttuala, Olli Gröhn, Piia Valonen, Risto A. Kauppinen, Kristiina Tyynelä
Publikováno v:
Cancer Gene Therapy. 9:338-345
The design and evaluation of therapeutic gene transfection protocols and vectors are under extensive development. Magnetic resonance imaging (MRI) techniques can aid considerably in the development of experimental treatment approaches, as well as in
Autor:
Miika T. Nieminen, Mika M. Hyttinen, Juhana M. Hakumäki, Jarno Rieppo, Johanna Silvennoinen, Heikki J. Helminen, Juha Töyräs, Jukka S. Jurvelin
Publikováno v:
Magnetic Resonance in Medicine. 46:487-493
It has been suggested that orientational changes in the collagen network of articular cartilage account for the depthwise T2 anisotropy of MRI through the magic angle effect. To investigate the relationship between laminar T2 appearance and collagen
Publikováno v:
Neuroscience Letters. 212:151-154
Changes in cerebral macromolecular 1H nuclear magnetic resonance (NMR) spectrum were studied in cortical brain slices in vitro. Aglycaemic hypoxia irreversibly increased various short T2 spectral components at 1.8-0.8 ppm in concordance with energy l