Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers

Autor: Rik Ossenkoppele, Juhan Reimand, Ruben Smith, Antoine Leuzy, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Henrik Zetterberg, the Alzheimer's Disease Neuroimaging Initiative, Philip Scheltens, Jeffrey L Dage, Femke Bouwman, Kaj Blennow, Niklas Mattsson‐Carlgren, Shorena Janelidze, Oskar Hansson

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-15 (2021)

Abstract PET, CSF and plasma biomarkers of tau pathology may be differentially associated with Alzheimer's disease (AD)‐related demographic, cognitive, genetic and neuroimaging markers. We examined 771 participants with normal cognition, mild cogni

Externí odkaz: https://doaj.org/article/057a0cbad93e4950bcab674977a33f6d

PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases

Autor: Juhan Reimand, Arno de Wilde, Charlotte E. Teunissen, Marissa Zwan, Albert D. Windhorst, Ronald Boellaard, Frederik Barkhof, Wiesje M. van der Flier, Philip Scheltens, Bart N. M. van Berckel, Rik Ossenkoppele, Femke Bouwman

Publikováno v: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-16 (2019)

Abstract Background Amyloid-β PET and CSF Aβ42 yield discordant results in 10–20% of memory clinic patients, possibly providing unique information. Although the predictive power of demographic, clinical, genetic, and imaging features for amyloid

Externí odkaz: https://doaj.org/article/38e9cf71018d42679c12dceee4186115

Association of amyloid-β CSF/PET discordance and tau load 5 years later

Autor: Lyduine Collij, Alzheimer’s Disease Neuroimaging Initiative, Juhan Reimand, Femke Bouwman, Philip Scheltens, Rik Ossenkoppele

Publikováno v: Alzheimer's Disease Neuroimaging Initiative 2020, ' Association of amyloid-β CSF/PET discordance and tau load 5 years later ', Neurology, vol. 95, no. 19, pp. e2648-e2657 . https://doi.org/10.1212/WNL.0000000000010739
Neurology, 95(19), e2648-e2657. Lippincott Williams and Wilkins
Neurology

ObjectiveTo investigate the association between discordant β-amyloid (Aβ) PET and CSF biomarkers at baseline and the emergence of tau pathology 5 years later.MethodsWe included 730 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69912c7c485750fbe41bda33b71a405
https://doi.org/10.1212/wnl.0000000000010739

Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer’s disease

Autor: Albert D. Windhorst, Bart N.M. van Berckel, Emma M. Coomans, Denise Visser, Rik Ossenkoppele, Wiesje M. van der Flier, Sander C.J. Verfaillie, Juhan Reimand, Tessa Timmers, Philip Scheltens, Ronald Boellaard, Emma E. Wolters, Hayel Tuncel

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, 47(13), 3165-3175. Springer Verlag
Visser, D, Wolters, E E, Verfaillie, S C J, Coomans, E M, Timmers, T, Tuncel, H, Reimand, J, Boellaard, R, Windhorst, A D, Scheltens, P, van der Flier, W M, Ossenkoppele, R & van Berckel, B N M 2020, ' Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer’s disease ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 47, no. 13, pp. 3165-3175 . https://doi.org/10.1007/s00259-020-04831-w

Purpose We aimed to investigate associations between tau pathology and relative cerebral blood flow (rCBF), and their relationship with cognition in Alzheimer’s disease (AD), by using a single dynamic [18F]flortaucipir positron emission tomography

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6317dcd946ff023512a8585e44f738a1
https://doi.org/10.1007/s00259-020-04831-w

Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18 F-Flutemetamol PET

Autor: Juhan Reimand, Marissa D. Zwan, Isadora Lopes Alves, Adriaan A. Lammertsma, Daniëlle M. E. van Assema, Pieter Jelle Visser, Lyduine E. Collij, Alle Meije Wink, Mara ten Kate, Frederik Barkhof, Philip Scheltens, Elles Konijnenberg, Maqsood Yaqub, Bart N.M. van Berckel, Anouk den Braber

Publikováno v: Journal of Nuclear Medicine
Journal of Nuclear Medicine, 60(4), 541-547. Society of Nuclear Medicine and Molecular Imaging
Collij, L, Konijnenberg, E, Reimand, J, Ten Kate, M, Den Braber, A, Lopes Alves, I, Zwan, M, Yaqub, M, Van Assema, D, Wink, A M, Lammertsma, A, Scheltens, P, Visser, P J, Barkhof, F & Van Berckel, B 2019, ' Assessing Amyloid Pathology in Cognitively Normal Subjects using [18F]Flutemetamol PET : Comparing Visual Reads and Quantitative Methods ', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 60, no. 4, pp. 541-547 . https://doi.org/10.2967/jnumed.118.211532
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 60(5), 541-547. Society of Nuclear Medicine Inc.
Collij, L E, Konijnenberg, E, Reimand, J, Kate, M T, Braber, A D, Alves, I L, Zwan, M, Yaqub, M, van Assema, D M E, Wink, A M, Lammertsma, A A, Scheltens, P, Visser, P J, Barkhof, F & van Berckel, B N M 2019, ' Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18 F-Flutemetamol PET : Comparing Visual Reads and Quantitative Methods ', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 60, no. 5, pp. 541-547 . https://doi.org/10.2967/jnumed.118.211532
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 60(4), 541-547

Our objective was to determine the optimal approach for assessing amyloid disease in a cognitively normal elderly population.Methods:Dynamic18F-flutemetamol PET scans were acquired using a coffee-break protocol (a 0- to 30-min scan and a 90- to 110-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53eddd6471e324297613b9c663b91981
https://doi.org/10.2967/jnumed.118.211532