Výsledky vyhledávání - "Juha Yrjänheikki"

Akademický článek

Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study

Autor: Christoph Schindler, Jacek Mikosiński, Pawel Mikosiński, Hanna-Riikka Kärkkäinen, Mirka Sanio, Jere Kurkipuro, Igor Mierau, Wesley Smith, Aki Vartiainen, Laurent Décory, Dirk Weber, Thomas Wirth, Juha Yrjänheikki, Sebastian Schellong, Haritha Samaranayake

Publikováno v: Therapeutic Advances in Endocrinology and Metabolism, Vol 15 (2024)

Background: Diabetic foot ulcer (DFU) is a common and highly morbid complication of diabetes with high unmet medical needs. AUP1602-C, a topical four-in-one gene therapy medicinal product (GTMP), consisting of a Lactococcus cremoris strain that produ

Externí odkaz: https://doaj.org/article/d62825e4b1614b6989ec62c8e21d41b2

Zobrazit plný text záznamu

Akademický článek

Four in one-Combination therapy using live Lactococcus lactis expressing three therapeutic proteins for the treatment of chronic non-healing wounds.

Autor: Jere Kurkipuro, Igor Mierau, Thomas Wirth, Haritha Samaranayake, Wesley Smith, Hanna-Riikka Kärkkäinen, Mirka Tikkanen, Juha Yrjänheikki

Publikováno v: PLoS ONE, Vol 17, Iss 2, p e0264775 (2022)

Diabetes mellitus is one of the major concerns for health care systems, affecting 382 million people worldwide. Among the different complications of diabetes, lower limbs chronic ulceration is a common, severe and costly cause of morbidity. Diabetic

Externí odkaz: https://doaj.org/article/d70ba555e63c4f58bc329d0754c285dc

Zobrazit plný text záznamu

Four in one-Combination therapy using live Lactococcus lactis expressing three therapeutic proteins for the treatment of chronic non-healing wounds

Autor: Jere Kurkipuro, Igor Mierau, Thomas Wirth, Haritha Samaranayake, Wesley Smith, Hanna-Riikka Kärkkäinen, Mirka Tikkanen, Juha Yrjänheikki

Publikováno v: PloS one. 17(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1682e8e9ddea3fb8ee6b9b994c92918
https://pubmed.ncbi.nlm.nih.gov/35226700

Zobrazit plný text záznamu

Interleukin-1 beta-induced expression of the prostaglandin E2-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB

Autor: Michael Hüll, Juha Yrjänheikki, Jeroen J.M. Hoozemans, Ravi Shankar Akundi, Anne Waschbisch, Bernd L. Fiebich, Nina Virtainen, Robert Veerhuis, M. Lienhard Schmitz, Eduardo Candelario-Jalil, Helen Slawik

Publikováno v: Journal of Neurochemistry. 96:680-693

Both interleukin-1beta (IL-1beta) and prostaglandins (PGs) are important mediators of physiological and pathophysiological processes in the brain. PGE2 exerts its effects by binding to four different types of PGE2 receptors named EP1-EP4. EP3 has fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02054c727058887547cbdec6edfa8d58
https://doi.org/10.1111/j.1471-4159.2005.03599.x

Zobrazit plný text záznamu

Spreading Depression–Induced Expression of c-fos and Cyclooxygenase-2 in Transgenic Mice that Overexpress Human Copper/Zinc-Superoxide Dismutase

Autor: Jari Koistinaho, Pak H. Chan, Alexander de Crespigny, Juha Yrjänheikki, Michael E. Moseley, Jean-Christophe Copin

Publikováno v: Journal of Neurotrauma. 17:713-718

Spreading depression (SD) is a wave of sustained depolarization challenging the energy metabolism of cells without causing irreversible damage. SD is a major mechanism of gene induction that takes place in cortical injury, including ischemia. We stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201fa9e48b97cc0fbd2f47a1b7af7a30
https://doi.org/10.1089/089771500415445

Zobrazit plný text záznamu

Spreading Depression–Induced Gene Expression Is Regulated by Plasma Glucose

Autor: Jari Koistinaho, Pak H. Chan, Juha Yrjänheikki, Sanna Pasonen

Publikováno v: Stroke. 30:114-119

Background and Purpose —Plasma glucose and spreading depression (SD) are both determinants of brain ischemia. The purpose of this study was to examine whether plasma glucose affects SD-induced gene expression in the cortex. Methods —SD was induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141950dcaceeaecb545f20908bdc9f94
https://doi.org/10.1161/01.str.30.1.114

Zobrazit plný text záznamu

Induction of ornithine decarboxylase mRNA in transient focal cerebral ischemia in the rat

Autor: Susanna Miettinen, Jari Koistinaho, Juha Yrjänheikki, Riitta Keinänen

Publikováno v: Neuroscience Letters. 239:69-72

We used in situ hybridization to localize the long-term changes in ornithine decarboxylase (ODC) expression after a 90 min occlusion of the middle cerebral artery (MCAO) in the rat. The ODC mRNA was induced in the ipsilateral dentate gyrus (DG) and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59e94eef0370aff082d93b579ddd724
https://doi.org/10.1016/s0304-3940(97)00890-2

Zobrazit plný text záznamu

Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N -methyl- d -aspartic acid-receptors and phospholipase A 2

Autor: Jari Koistinaho, Susanna Miettinen, Francesca R. Fusco, Reina Roivainen, Riitta Keinänen, Juha Yrjänheikki, Timo Hirvonen, Matti Närhi, Tomas Hökfelt

Publikováno v: Proceedings of the National Academy of Sciences. 94:6500-6505

Repetitive spreading depression (SD) waves, involving depolarization of neurons and astrocytes and up-regulation of glucose consumption, is thought to lower the threshold of neuronal death during and immediately after ischemia. Using rat models for S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e02af6031f27e42b51396ae136963d
https://doi.org/10.1073/pnas.94.12.6500

Zobrazit plný text záznamu

Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease

Autor: Susan J. Hendricks, David Howland, Juha Yrjänheikki, Larry Park, Bruno Buisson, Taneli Heikkinen, Amyaouch Bradaia, Vahri Beaumont, Jukka Puoliväli, Nina Vartiainen, Ignacio Munoz-Sanjuan, Outi Kontkanen, Kristian Wadel, Kimmo Lehtimäki, Jacob R. Glaser, Chrystelle Touller

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e50717 (2012)
PLoS ONE

Huntington's disease (HD) is an autosomal neurodegenerative disorder, characterized by severe behavioral, cognitive, and motor deficits. Since the discovery of the huntingtin gene (HTT) mutation that causes the disease, several mouse lines have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8108aa260b76a639f8099cb375c3f4
http://europepmc.org/articles/PMC3527436?pdf=render

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání