Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Juha Saarikettu"'
Autor:
Juha Saarikettu, Saara Lehmusvaara, Marko Pesu, Ilkka Junttila, Juha Partanen, Petra Sipilä, Matti Poutanen, Jie Yang, Teemu Haikarainen, Olli Silvennoinen
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 5, Pp 183-198 (2023)
Abstract Snd1 is an evolutionarily conserved RNA‐binding protein implicated in several regulatory processes in gene expression including activation of transcription, mRNA splicing, and microRNA decay. Here, we have investigated the outcome of Snd1
Externí odkaz:
https://doaj.org/article/16f18b224da54a86aa8f9e82d02f1857
Autor:
Saara Lehmusvaara, Teemu Haikarainen, Juha Saarikettu, Guillermo Martinez Nieto, Olli Silvennoinen
Publikováno v:
Cancers, Vol 14, Iss 13, p 3100 (2022)
SND1 is an RNA-binding protein overexpressed in large variety of cancers. SND1 has been proposed to enhance stress tolerance in cancer cells, but the molecular mechanisms are still poorly understood. We analyzed the expression of 372 miRNAs in the co
Externí odkaz:
https://doaj.org/article/335249a8a960413580a8e3a89e444458
Autor:
Jonna Saarimäki-Vire, Diego Balboa, Mark A. Russell, Juha Saarikettu, Matias Kinnunen, Salla Keskitalo, Amrinder Malhi, Cristina Valensisi, Colin Andrus, Solja Eurola, Heli Grym, Jarkko Ustinov, Kirmo Wartiovaara, R. David Hawkins, Olli Silvennoinen, Markku Varjosalo, Noel G. Morgan, Timo Otonkoski
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 281-294 (2017)
Summary: Activating germline mutations in STAT3 were recently identified as a cause of neonatal diabetes mellitus associated with beta-cell autoimmunity. We have investigated the effect of an activating mutation, STAT3K392R, on pancreatic development
Externí odkaz:
https://doaj.org/article/ec346f9834cd42bbb148c06590ce525e
Autor:
Salla Keskitalo, Amrinder Malhi, Matias Kinnunen, Solja Eurola, Cristina Valensisi, Mark Russell, Timo Otonkoski, Heli Grym, Jarkko Ustinov, Markku Varjosalo, Noel G. Morgan, Kirmo Wartiovaara, Olli Silvennoinen, Jonna Saarimäki-Vire, R. David Hawkins, Diego Balboa, Colin Andrus, Juha Saarikettu
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 281-294 (2017)
Summary: Activating germline mutations in STAT3 were recently identified as a cause of neonatal diabetes mellitus associated with beta-cell autoimmunity. We have investigated the effect of an activating mutation, STAT3K392R, on pancreatic development
Autor:
Xingjie Gao, Mei Mei, Olli Silvennoinen, Yi Zhang, Juan Song, Xiaoteng Cui, Jie Yang, Minxin Wei, Chao Su, Lingbiao Xin, Jie Shao, Lin Ge, Xi Yang, Jinyan He, Zhi Yao, Xue Fu, Juha Saarikettu
Publikováno v:
FEBS Journal. 282:874-890
Stress granules (SGs) and processing bodies (PBs) comprise the main types of cytoplasmic RNA foci during stress. Our previous data indicate that knockdown of human Tudor staphylococcal nuclease (Tudor-SN) affects the aggregation of SGs. However, the
Autor:
Olli Silvennoinen, Xiujuan Zhao, Zhongchao Duan, Lingbiao Xin, Xiao Fu, Juha Saarikettu, Xi Yang, Zhi Yao, Jie Yang, Chao Su, Minxin Wei
Publikováno v:
Journal of Biological Chemistry. 289:8364-8374
Adipogenesis, in which mesenchymal precursor cells differentiate into mature adipocytes, is a well orchestrated process. In the present study we identified Tudor-SN as a novel co-activator of the transcription factor peroxisome proliferator-activated
Publikováno v:
Tissue and Cell. 45:21-31
Tudor-SN (SND1, p100) has been shown to function as a transcriptional coactivator as well as a modulator of RNA metabolism and biogenesis and a component in the RNA-induced silencing complex (RISC). Tudor-SN consists of five repeats of staphylococcus
Publikováno v:
Hybridoma. 29:231-236
Tudor-SN is a multifunctional regulator of gene expression that has been shown to function as a transcriptional co-activator, regulator of miRNA processing, mRNA splicing, and stability. Tudor-SN has also been identified as a component in RNA-induced
Publikováno v:
Molecular Biology of the Cell. 19:2509-2519
The members of the MyoD family of basic helix-loop-helix (bHLH) transcription factors are critical regulators of skeletal muscle differentiation that function as heterodimers with ubiquitously expressed E-protein bHLH transcription factors. These het
Autor:
Yurong Da, Jie Yang, Neil Shaw, Olli Silvennoinen, Hao Xu, Chongyun Cheng, Zhi-Jie Liu, Min Zhao, Zihe Rao, Yang Li, Juha Saarikettu, Bi-Cheng Wang, Zhi Yao
Publikováno v:
Nature Structural & Molecular Biology. 14:779-784
The human p100 protein is a vital transcription regulator that increases gene transcription by forming a physical bridge between promoter-specific activators and the basal transcription machinery. Here we demonstrate that the tudor and SN (TSN) domai