Výsledky vyhledávání - "Juha Rutanen"

Extracellular Superoxide Dismutase Accelerates Endothelial Recovery and Inhibits In-Stent Restenosis in Stented Atherosclerotic Watanabe Heritable Hyperlipidemic Rabbit Aorta

Autor: Matias Inkala, Samar Basu, Juha Rutanen, Mikko O. Laukkanen, Max Levin, Jan Hinrich Bräsen, Tommi Heikura, Anna-Liisa Levonen, David Bergqvist, Seppo Ylä-Herttuala, Günter Klöppel, Olli Leppänen, Thomas Zeller, Fabian Ahrens, Hubertus Pietsch

Publikováno v: Journal of the American College of Cardiology. 50(23):2249-2253

ObjectivesThis study examined whether local gene therapy with extracellular superoxide dismutase (EC-SOD) could inhibit in-stent restenosis in atherosclerotic Watanabe heritable hyperlipidemic rabbits.BackgroundStenting causes an acute increase in su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de06c3e11f869469be6dd3d185f225b

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Nrf2 Gene Transfer Induces Antioxidant Enzymes and Suppresses Smooth Muscle Cell Growth In Vitro and Reduces Oxidative Stress in Rabbit Aorta In Vivo

Autor: Seppo Ylä-Herttuala, Matias Inkala, Anna-Liisa Levonen, Päivi Turunen, Elina Romppanen, Henna-Kaisa Jyrkkänen, Juha Rutanen, Kirsi Maatta, Tommi Heikura, Emilia Kansanen, Suvi Jauhiainen

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 27:741-747

Background— Reactive oxygen species (ROS) play a major role in vascular inflammation and pathophysiology of many vascular diseases such as atherosclerosis and injury-induced neointima formation after balloon angioplasty. Nuclear factor E2–related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780d6d51d24eb2ad03d735046bf81ece
https://doi.org/10.1161/01.atv.0000258868.80079.4d

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Gene transfer using the mature form of VEGF-D reduces neointimal thickening through nitric oxide-dependent mechanism

Autor: Suvi Jauhiainen, Tuomas T. Rissanen, Marcin Gruchała, Seppo Ylä-Herttuala, Matias Inkala, Steven A. Stacker, Juha Rutanen, Marc G. Achen, Anna-Mari Turunen, Teittinen M, Tommi Heikura, Jonna K. Koponen, Mikko Hiltunen, Mikko P. Turunen

Publikováno v: Gene Therapy. 12:980-987

Gene transfer to the vessel wall using vascular endothelial growth factors (VEGFs) has shown therapeutic potential for the treatment of restenosis. In this study, we evaluated the effect of catheter-mediated adenoviral (Ad) gene transfer of the matur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d51e7385aff1f4ede88aada82d6ba8
https://doi.org/10.1038/sj.gt.3302489

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Tissue Inhibitor of Metalloproteinase 1 Adenoviral Gene Therapy Alone Is Equally Effective in Reducing Restenosis as Combination Gene Therapy in a Rabbit Restenosis Model

Autor: Hanna L. Puhakka, Mikko P. Turunen, Seppo Ylä-Herttuala, Mikko Hiltunen, Päivi Turunen, Juha Rutanen

Publikováno v: Journal of Vascular Research. 42:361-367

Neointimal formation is a common feature after angioplasty, bypass grafting and stenting. Angioplasty damages endothelium, causing pathological changes in arteries which lead to smooth muscle cell proliferation, synthesis of extracellular matrix comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25b643fd9629c4a83b78820e9cbfa3c
https://doi.org/10.1159/000087120

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HIF-VEGF-VEGFR-2, TNF-α and IGF pathways are upregulated in critical human skeletal muscle ischemia as studied with DNA array

Autor: Juha Rutanen, Tiina T. Tuomisto, Tuomas T. Rissanen, Seppo Ylä-Herttuala, Anna Korkeela, Ismo Vajanto

Publikováno v: Atherosclerosis. 174:111-120

Critical lower limb ischemia is a common cause for amputation. To develop new therapeutic strategies, more information is needed about molecular mechanisms of tissue responses to ischemic stress and factors inducing angiogenesis. Using a DNA array of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c2c627adfe0e66d4f10800d0d424b5
https://doi.org/10.1016/j.atherosclerosis.2004.01.015

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Adenoviral Catheter-Mediated Intramyocardial Gene Transfer Using the Mature Form of Vascular Endothelial Growth Factor-D Induces Transmural Angiogenesis in Porcine Heart

Autor: Marja Hedman, Marcin Gruchała, Tommi Heikura, Antti Kivelä, Johanna E. Markkanen, Maija-Riitta Ordén, Tuomas T. Rissanen, Steven A. Stacker, Marc G. Achen, Seppo Ylä-Herttuala, Juha Hartikainen, Päivi Silvennoinen, Antti Hedman, Juha Rutanen

Publikováno v: Circulation. 109:1029-1035

Background— It is unclear what is the most efficient vector and growth factor for induction of therapeutic vascular growth in the heart. Furthermore, the histological nature of angiogenesis and potential side effects caused by different vascular en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f864479dcd088a62039d45b1f2d2bb4b
https://doi.org/10.1161/01.cir.0000115519.03688.a2

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Gene Expression in Macrophage-Rich Inflammatory Cell Infiltrates in Human Atherosclerotic Lesions as Studied by Laser Microdissection and DNA Array

Autor: Mervi S. Riekkinen, Tuomas T. Rissanen, Zsolt Kiraly, Tiina T. Tuomisto, Juha Rutanen, Seppo Ylä-Herttuala, Konrad Kölble, Kari Karkola, Helena Viita, Jan Hinrich Bräsen, Anna Korkeela

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 23:2235-2240

Objective— Inflammatory cells play an important role in atherogenesis. However, more information is needed about their gene expression profiles in human lesions. Methods and Results— We used laser microdissection (LMD) to isolate macrophage-rich

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ee03dbb94d1f7051de03f79155665e
https://doi.org/10.1161/01.atv.0000102551.91154.96

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Vascular endothelial growth factor-D expression in human atherosclerotic lesions

Autor: Mikko Hiltunen, Ismo Vajanto, Kari Karkola, Tomi Häkkinen, Kari Alitalo, Pia Leppänen, Tiina T. Tuomisto, Juha Rutanen, Steven A. Stacker, Tuomas T. Rissanen, Marc G. Achen, Seppo Ylä-Herttuala, Mari Niemi

Publikováno v: Cardiovascular Research. 59:971-979

Objective: Vascular endothelial growth factor-D (VEGF-D) is a recently characterized member of the VEGF family, but its expression in atherosclerotic lesions remains unknown. We studied the expression of VEGF-D and its receptors (VEGFR-2 and VEGFR-3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9344f48984168af3da6c27b01032cfe3
https://doi.org/10.1016/s0008-6363(03)00518-2

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Peptide-Retargeted Adenovirus Encoding a Tissue Inhibitor of Metalloproteinase-1 Decreases Restenosis after Intravascular Gene Transfer

Autor: Mikko Hiltunen, Jonna K. Koponen, Andrew C. Newby, Seppo Ylä-Herttuala, Olli Leppänen, Mikko P. Turunen, Hanna L. Puhakka, Ale Närvänen, Anna-Mari Turunen, Andrew H. Baker, Juha Rutanen

Publikováno v: Molecular Therapy. 6(3):306-312

In this study we have attached cyclic targeting peptides by way of a poly-lysine spacer on the surface of an adenovirus using a transglutaminase enzymatic reaction to enhance transduction efficiency and to modify tissue tropism in vivo. Nuclear targe

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Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF andLacZ

Autor: Outi Närvänen, Mikko Hippeläinen, Esko Alhava, Katja Arve, Juha Rutanen, Tiina T. Tuomisto, Seppo Ylä-Herttuala, Mikko Hiltunen, Tuomas T. Rissanen, Hannu Manninen, Ismo Vajanto, Heikki T. Räsänen

Publikováno v: The Journal of Gene Medicine. 4:371-380

Background Recent studies have suggested the therapeutic potential of vascular endothelial growth factor (VEGF) gene therapy in ischemic skeletal muscle. However, only limited information is available about the effects of VEGF gene therapy in differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70d46b5b0c1dd64b8cae03df06164bac
https://doi.org/10.1002/jgm.287

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