Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Juha Rantala"'
Autor:
Hannah Gagg, Greg Wells, Sarah J. Danson, Spencer J. Collis, Juha Rantala, Ola Rominiyi, Callum Jones, Thomas Helleday, Katie N. Myers, Connor McGarrity-Cottrell, Sophie T. Williams, Samantha Conroy
Publikováno v:
F1000Research, Vol 12 (2024)
With diminishing returns and high clinical failure rates from traditional preclinical and animal-based drug discovery strategies, more emphasis is being placed on alternative drug discovery platforms. Ex vivo approaches represent a departure from bot
Externí odkaz:
https://doaj.org/article/0d07e3d1808746329649b8bab6580273
Autor:
Hannah Gagg, Greg Wells, Sarah J. Danson, Spencer J. Collis, Juha Rantala, Ola Rominiyi, Callum Jones, Thomas Helleday, Katie N. Myers, Connor McGarrity-Cottrell, Sophie T. Williams, Samantha Conroy
Publikováno v:
F1000Research, Vol 12 (2023)
With diminishing returns and high clinical failure rates from traditional preclinical and animal-based drug discovery strategies, more emphasis is being placed on alternative drug discovery platforms. Ex vivo approaches represent a departure from bot
Externí odkaz:
https://doaj.org/article/563d9cb96d614270ab9d4531c06cee5a
Autor:
Tyler Risom, Ellen M. Langer, Margaret P. Chapman, Juha Rantala, Andrew J. Fields, Christopher Boniface, Mariano J. Alvarez, Nicholas D. Kendsersky, Carl R. Pelz, Katherine Johnson-Camacho, Lacey E. Dobrolecki, Koei Chin, Anil J. Aswani, Nicholas J. Wang, Andrea Califano, Michael T. Lewis, Claire J. Tomlin, Paul T. Spellman, Andrew Adey, Joe W. Gray, Rosalie C. Sears
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Resistance to therapy can be driven by intratumoral heterogeneity. Here, the authors show that drug tolerant persistent cell populations emerge during treatment, and these emergent populations arise through epigenetically mediated cell state transiti
Externí odkaz:
https://doaj.org/article/b334216fc1b74e778b875f012ede0e20
Autor:
Saara Laine, Heidi Högel, Tamiko Ishizu, Jussi Toivanen, Minna Yli-Karjanmaa, Tove J. Grönroos, Juha Rantala, Rami Mäkelä, Jarna C. Hannukainen, Kari K. Kalliokoski, Ilkka Heinonen
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
PurposeRac1 and its downstream target PAK1 are novel regulators of insulin and exercise-induced glucose uptake in skeletal muscle. However, it is not yet understood how different training intensities affect the expression of these proteins. Therefore
Externí odkaz:
https://doaj.org/article/d3cdb1b5acf441bfbefc744864a1e540
Autor:
Sakari Nikinmaa, Heikki Alapulli, Petri Auvinen, Martti Vaara, Juha Rantala, Esko Kankuri, Timo Sorsa, Jukka Meurman, Tommi Pätilä
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232775 (2020)
Antibacterial photodynamic therapy (aPDT) and antibacterial blue light (aBL) are emerging treatment methods auxiliary to mechanical debridement for periodontitis. APDT provided with near-infrared (NIR) light in conjunction with an indocyanine green (
Externí odkaz:
https://doaj.org/article/177a257d053e427490238e582c31acd0
Autor:
Sakari Nikinmaa, Anna Podonyi, Peter Raivio, Jukka Meurman, Timo Sorsa, Juha Rantala, Esko Kankuri, Tuomas Tauriainen, Tommi Pätilä
Publikováno v:
Antibiotics, Vol 10, Iss 10, p 1240 (2021)
New means to reduce excessive antibiotic use are urgently needed. This study tested dual-light aPDT against Staphylococcus aureus biofilm with different relative ratios of light energy with indocyanine green. We applied single-light aPDT (810 nm aPDT
Externí odkaz:
https://doaj.org/article/b80cebf6f03b408dad843911d71e3743
Autor:
Sakari Nikinmaa, Niina Moilanen, Timo Sorsa, Juha Rantala, Heikki Alapulli, Anja Kotiranta, Petri Auvinen, Esko Kankuri, Jukka H. Meurman, Tommi Pätilä
Publikováno v:
Dentistry Journal, Vol 9, Iss 5, p 52 (2021)
Aim: This study aimed to determine the feasibility and first efficacy of indocyanine green (ICG)-assisted antimicrobial photodynamictherapy (aPDT) as activated using LED light to the dental plaque. Methods: Fifteen healthy adults were assigned to thi
Externí odkaz:
https://doaj.org/article/55174d5171464315ad8e422f9810dbee
Autor:
Riikka J. Lund, Kaisa Huhtinen, Jussi Salmi, Juha Rantala, Elizabeth V. Nguyen, Robert Moulder, David R. Goodlett, Riitta Lahesmaa, Olli Carpén
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract High-grade serous ovarian cancer is the most common ovarian cancer type. Although the combination of surgery and platinum-taxane chemotherapy provide an effective treatment, drug resistance frequently occurs leading to poor outcome. In order
Externí odkaz:
https://doaj.org/article/6c01c760084d476eacca4d213f37d8c8
Autor:
Giuseppe Balistreri, Johanna Viiliäinen, Mikko Turunen, Raquel Diaz, Lauri Lyly, Pirita Pekkonen, Juha Rantala, Krista Ojala, Grzegorz Sarek, Mari Teesalu, Oxana Denisova, Karita Peltonen, Ilkka Julkunen, Markku Varjosalo, Denis Kainov, Olli Kallioniemi, Marikki Laiho, Jussi Taipale, Sampsa Hautaniemi, Päivi M Ojala
Publikováno v:
PLoS Pathogens, Vol 12, Iss 2, p e1005424 (2016)
Kaposi's sarcoma herpesvirus (KSHV) causes Kaposi's sarcoma and certain lymphoproliferative malignancies. Latent infection is established in the majority of tumor cells, whereas lytic replication is reactivated in a small fraction of cells, which is
Externí odkaz:
https://doaj.org/article/207f588768644df382ad16ba122175cb
Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer.
Autor:
Lise Lotte Christensen, Anja Holm, Juha Rantala, Olli Kallioniemi, Mads H Rasmussen, Marie S Ostenfeld, Frederik Dagnaes-Hansen, Bodil Øster, Troels Schepeler, Heidi Tobiasen, Kasper Thorsen, Oliver M Sieber, Peter Gibbs, Philippe Lamy, Torben F Hansen, Anders Jakobsen, Eva M Riising, Kristian Helin, Jan Lubinski, Rikke Hagemann-Madsen, Søren Laurberg, Torben F Ørntoft, Claus L Andersen
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e96767 (2014)
MicroRNAs (miRNAs) play a critical role in many biological processes and are aberrantly expressed in human cancers. Particular miRNAs function either as tumor suppressors or oncogenes and appear to have diagnostic and prognostic significance. Althoug
Externí odkaz:
https://doaj.org/article/22ba41fcd8b3409d804194563757951f