Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Juha R. Savinainen"'
Autor:
Niina Aaltonen, Prosanta K. Singha, Hermina Jakupović, Thomas Wirth, Haritha Samaranayake, Sanna Pasonen-Seppänen, Kirsi Rilla, Markku Varjosalo, Laura E. Edgington-Mitchell, Paulina Kasperkiewicz, Marcin Drag, Sara Kälvälä, Eemeli Moisio, Juha R. Savinainen, Jarmo T. Laitinen
Publikováno v:
Biological Procedures Online, Vol 22, Iss 1, Pp 1-21 (2020)
Abstract Background Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP
Externí odkaz:
https://doaj.org/article/39a46c768cee473fbdc8573d58d1d4d5
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1204 (2021)
In migraine pain, cannabis has a promising analgesic action, which, however, is associated with side psychotropic effects. To overcome these adverse effects of exogenous cannabinoids, we propose migraine pain relief via activation of the endogenous c
Externí odkaz:
https://doaj.org/article/4116fc5d607b46508c3495e1512458f5
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2413-2424 (2012)
In the central nervous system, three enzymes belonging to the serine hydrolase family are thought to regulate the life time of the endocannabinoid 2-arachidonoylglycerol (C20:4) (2-AG). From these, monoacylglycerol lipase (MAGL) is well characterized
Externí odkaz:
https://doaj.org/article/13d72efcba9d436c8b6f264f8ec5bd5a
Autor:
Karine Mardon, Jayendra Z. Patel, Juha R. Savinainen, Damion H. R. Stimson, Caitlin R. M. Oyagawa, Natasha L. Grimsey, Mary-anne Migotto, Grace F. M. Njiru, Brett R. Hamilton, Gary Cowin, Jari Yli-Kauhaluoma, Wim Vanduffel, Idriss Blakey, Rajiv Bhalla, Christopher Cawthorne, Sofie Celen, Guy Bormans, Kristofer J Thurecht, Muneer Ahamed
Publikováno v:
Journal of Medicinal Chemistry. 66:538-552
Autor:
Tony S. Eteläinen, M. Catarina Silva, Johanna K. Uhari-Väänänen, Francesca De Lorenzo, Maria H. Jäntti, Hengjing Cui, Marta Chavero-Pieres, Tommi Kilpeläinen, Christina Mechtler, Reinis Svarcbahs, Erin Seppälä, Juha R. Savinainen, Elena Puris, Gert Fricker, Mikko Gynther, Ulrika H. Julku, Henri J. Huttunen, Stephen J. Haggarty, Timo T. Myöhänen
Publikováno v:
Science Translational Medicine. 15
Tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau filaments. Protein phosphatase 2A (PP2A) is a major tau dephosphorylating phosphatase, and a decrea
Autor:
Eija Kalso, Jari Yli-Kauhaluoma, Juha R. Savinainen, Vânia M. Moreira, Tiina Ahonen, Jarmo T. Laitinen
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1269-1273
[Image: see text] Screening of an in-house library of compounds identified 12-thiazole abietanes as a new class of reversible inhibitors of the human metabolic serine hydrolase. Further optimization of the first hit compound lead to the 2-methylthiaz
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1204, p 1204 (2021)
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1204, p 1204 (2021)
In migraine pain, cannabis has a promising analgesic action, which, however, is associated with side psychotropic effects. To overcome these adverse effects of exogenous cannabinoids, we propose migraine pain relief via activation of the endogenous c
Autor:
Thomas Wirth, Eemeli Moisio, Kirsi Rilla, Paulina Kasperkiewicz, Prosanta K. Singha, Markku Varjosalo, Sanna Pasonen-Seppänen, Jarmo T. Laitinen, Sara Kälvälä, Marcin Drag, Juha R. Savinainen, Hermina Jakupović, Laura E. Edgington-Mitchell, Niina Aaltonen, Haritha Samaranayake
Publikováno v:
Biological Procedures
Biological Procedures Online, Vol 22, Iss 1, Pp 1-21 (2020)
Biological Procedures Online, Vol 22, Iss 1, Pp 1-21 (2020)
Background Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP) using f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc07b4597e8c09e23c74070010b5b96d
http://hdl.handle.net/10138/317397
http://hdl.handle.net/10138/317397
Autor:
Jarmo T. Laitinen, Steffi Goffart, Tapio Nevalainen, Jayendra Z. Patel, Dina Navia-Paldanius, Tuomo Laitinen, Juha R. Savinainen, Hermina Jakupović, Tiina Jääskeläinen, Sanna Pasonen-Seppänen, Miriam López Navarro
Publikováno v:
European Journal of Pharmaceutical Sciences. 93:253-263
ABHD11 (α/β-hydrolase domain containing 11) is a non-annotated enzyme belonging to the family of metabolic serine hydrolases (mSHs). Its natural substrates and products are unknown. Using competitive activity-based protein profiling (ABPP) to ident
Autor:
Haritha Samaranayake, Marcin Drag, Sanna Pasonen-Seppänen, Sara Kälvälä, Laura E. Edgington-Mitchell, Jarmo T. Laitinen, Eemeli Moisio, Markku Varjosalo, Prosanta K. Singha, Paulina Kasperkiewicz, Juha R. Savinainen, Hermina Jakupović, Niina Aaltonen, Kirsi Rilla, Thomas Wirth
Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP) using fluorophosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a12dc98db7aac398bba304bd842d700