Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Juha P Väyrynen"'
Autor:
Niko Hiltunen, Niko Kemi, Juha P Väyrynen, Jan Böhm, Joonas H Kauppila, Heikki Huhta, Olli Helminen
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302813 (2024)
Toll-like receptors (TLRs) are pattern recognition receptors of the innate immunity. TLRs are known to mediate both antitumor effects and tumorigenesis. TLRs are abundant in many cancers, but their expression in small bowel neuroendocrine tumors (SB-
Externí odkaz:
https://doaj.org/article/21a40a0a3dc24e33a7671cc246f69d35
Autor:
Tomotaka Ugai, Takashi Shimizu, Hidetaka Kawamura, Satoko Ugai, Yasutoshi Takashima, Genki Usui, Juha P Väyrynen, Kazuo Okadome, Koichiro Haruki, Naohiko Akimoto, Yohei Masugi, Annacarolina daSilva, Kosuke Mima, Xuehong Zhang, Andrew T Chan, Molin Wang, Wendy S Garrett, Gordon J Freeman, Jeffrey A Meyerhardt, Jonathan A Nowak, Mingyang Song, Marios Giannakis, Shuji Ogino
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 8, Pp n/a-n/a (2023)
Abstract Objectives The CD274 (programmed cell death 1 ligand 1, PD‐L1)/PDCD1 (programmed cell death 1, PD‐1) immune checkpoint axis is known to regulate the antitumor immune response. Evidence also supports an immunosuppressive effect of Fusobac
Externí odkaz:
https://doaj.org/article/6d5f4ff4a6054b57bc63ecd44396a8c0
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0286270 (2023)
Tumor-stroma ratio (TSR) is a prognostic factor for many types of solid tumors. In this study, we propose a method for automated estimation of TSR from histopathological images of colorectal cancer. The method is based on convolutional neural network
Externí odkaz:
https://doaj.org/article/4c9cc0ff0ed34a3488b09052ca6108f7
Autor:
Mingyang Song, Jennifer Borowsky, Reiko Nishihara, Marios Giannakis, Melissa Zhao, Sara A Väyrynen, Juha P Väyrynen, Koichiro Haruki, Mai Chan Lau, Andressa Dias Costa, Tomotaka Ugai, Junko Kishikawa, Naohiko Akimoto, Tzuu-Wang Chang, Kenji Fujiyoshi, Kota Arima, Tyler S Twombly, Annacarolina Da Silva, Jonathan A Nowak
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background Myeloid cells represent an abundant yet heterogeneous cell population in the colorectal cancer microenvironment, and their roles remain poorly understood.Methods We used multiplexed immunofluorescence combined with digital image analysis t
Externí odkaz:
https://doaj.org/article/1713d1cd252f4ab0b5fc14ac83bd2c53
Autor:
Hanna-Leena Kelhälä, Riitta Palatsi, Nanna Fyhrquist, Sari Lehtimäki, Juha P Väyrynen, Matti Kallioinen, Minna E Kubin, Dario Greco, Kaisa Tasanen, Harri Alenius, Beatrice Bertino, Isabelle Carlavan, Bruno Mehul, Sophie Déret, Pascale Reiniche, Philippe Martel, Carine Marty, Ulrike Blume-Peytavi, Johannes J Voegel, Antti Lauerma
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105238 (2014)
The mechanisms of inflammation in acne are currently subject of intense investigation. This study focused on the activation of adaptive and innate immunity in clinically early visible inflamed acne lesions and was performed in two independent patient
Externí odkaz:
https://doaj.org/article/2be799c3d05146d78144b913059b859a
Autor:
Naohiko Akimoto, Juha P. Väyrynen, Melissa Zhao, Tomotaka Ugai, Kenji Fujiyoshi, Jennifer Borowsky, Rong Zhong, Koichiro Haruki, Kota Arima, Mai Chan Lau, Junko Kishikawa, Tyler S. Twombly, Yasutoshi Takashima, Mingyang Song, Xuehong Zhang, Kana Wu, Andrew T. Chan, Jeffrey A. Meyerhardt, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe relationships between tumor stromal features (such as desmoplastic reaction, myxoid stroma, and keloid-like collagen bundles) and immune cells in the colorectal carcinoma microenvironment have not yet been fully characterized.MethodsIn
Externí odkaz:
https://doaj.org/article/d20c46f0ff264504a3db9b0c636524b9
Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer
Autor:
Juha P. Väyrynen, Sara A. Väyrynen, Päivi Sirniö, Ilkka Minkkinen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J. Karttunen, Anne Tuomisto, Markus J. Mäkinen
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Abstract Background Platelets not only contribute to hemostasis but also to the regulation of inflammatory reactions and cancer pathogenesis. We hypothesized that blood platelet count would be associated with systemic inflammation, the densities of t
Externí odkaz:
https://doaj.org/article/cdb7cee9f9f1423098398a7819b66244
Autor:
Raila Aro, Sanna Meriläinen, Päivi Sirniö, Juha P. Väyrynen, Vesa-Matti Pohjanen, Karl-Heinz Herzig, Tero T. Rautio, Elisa Mäkäräinen, Reetta Häivälä, Kai Klintrup, Markus J. Mäkinen, Juha Saarnio, Anne Tuomisto
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 9, p 2656 (2022)
Cancer patients commonly present sarcopenia, myosteatosis, and systemic inflammation, which are risk factors of poor survival. In this study, sarcopenia and myosteatosis were defined from preoperative body computed tomography scans of 222 colorectal
Externí odkaz:
https://doaj.org/article/cb7487c436d8484c94159c06bebb66e6
Autor:
Kenji Fujiyoshi, Juha P. Väyrynen, Jennifer Borowsky, David J. Papke, Jr., Kota Arima, Koichiro Haruki, Junko Kishikawa, Naohiko Akimoto, Tomotaka Ugai, Mai Chan Lau, Simeng Gu, Shanshan Shi, Melissa Zhao, Annacarolina Fabiana Lucia Da Silva, Tyler S. Twombly, Hongmei Nan, Jeffrey A. Meyerhardt, Mingyang Song, Xuehong Zhang, Kana Wu, Andrew T. Chan, Charles S. Fuchs, Jochen K. Lennerz, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Publikováno v:
EBioMedicine, Vol 57, Iss , Pp 102860- (2020)
Background: Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colo
Externí odkaz:
https://doaj.org/article/36f00dc68e4c4aca9c93d5fc3721bf2b
Autor:
Pei-Chen Tsai, Tsung-Hua Lee, Kun-Chi Kuo, Fang-Yi Su, Tsung-Lu Michael Lee, Eliana Marostica, Tomotaka Ugai, Melissa Zhao, Mai Chan Lau, Juha P. Väyrynen, Marios Giannakis, Yasutoshi Takashima, Seyed Mousavi Kahaki, Kana Wu, Mingyang Song, Jeffrey A. Meyerhardt, Andrew T. Chan, Jung-Hsien Chiang, Jonathan Nowak, Shuji Ogino, Kun-Hsing Yu
Publikováno v:
Nature Communications. 14
Histopathologic assessment is indispensable for diagnosing colorectal cancer (CRC). However, manual evaluation of the diseased tissues under the microscope cannot reliably inform patient prognosis or genomic variations crucial for treatment selection