Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Juha Ollila"'
Autor:
Mauno Vihinen, Juha Ollila
Publikováno v:
Molecular Immunology. 44:3537-3551
B-cell development into antibody producing cells is a complex process that relies on the tightly controlled production of hundreds of genes and proteins. A B-cell is activated through the B-cell receptor (BCR) and this activation is modified by diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e39b222b64657575d35574dae5018c8
https://doi.org/10.1016/j.molimm.2007.03.009
https://doi.org/10.1016/j.molimm.2007.03.009
Autor:
Juha Ollila, Mauno Vihinen
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 37:518-523
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The fact that humans express a very large repertoire of antibodies is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6ba62de7b0ac343fa029c087f25248
https://doi.org/10.1016/j.biocel.2004.09.007
https://doi.org/10.1016/j.biocel.2004.09.007
Autor:
Kowan Ja Jee, Kristiina Heikinheimo, Juha Ollila, Ilmo Leivo, Merja Laine, Bálint Nagy, Sakari Knuutila
Publikováno v:
Cancer Genetics and Cytogenetics. 156:104-113
Gene expression profiles were studied in 13 cases of salivary gland carcinoma including mucoepidermoid carcinoma (MEC), acinic cell carcinoma (ACC), and salivary duct carcinoma (SDC) using a cDNA array. A total of 162 genes were deregulated. Only 5 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2b6813c3ad09fcaa2bd63cbc15cec8
https://doi.org/10.1016/j.cancergencyto.2004.04.016
https://doi.org/10.1016/j.cancergencyto.2004.04.016
Publikováno v:
Tampere University
Grouping of genes into clusters according to their expression levels is important for deriving biological information, e.g., on gene functions based on microarray and other related analyses. The paper introduces the selection of the number of cluster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3128f44816135bb881679ad1caafba98
https://doi.org/10.1089/cmb.2004.11.660
https://doi.org/10.1089/cmb.2004.11.660
Autor:
Richard Rosenquist, A. Ferrer, Sakari Knuutila, Juhani Vilpo, Ulf Thunberg, Mauno Vihinen, Bálint Nagy, Gerard Tobin, Juha Ollila, Yan Aalto
Publikováno v:
Cancer Genetics and Cytogenetics. 153:69-72
The mutation status of the immunoglobulin heavy chain variable regions (IgVH) has been found to be a good prognostic indicator for B-cell chronic lymphocytic leukemia (CLL) because unmutated VH genes are associated with rapid disease progression and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a4d5d8eefb575e925c3704f69bd371
https://doi.org/10.1016/j.cancergencyto.2003.12.016
https://doi.org/10.1016/j.cancergencyto.2003.12.016
Autor:
Ismo Ulmanen, Petra Eskelin, Maria Halonen, Jorma J. Palvimo, Jani Saarela, Juha Ollila, Taina Rüppell, Hannele Kangas, Tanja Ilmarinen, Meelis Kolmer, Mauno Vihinen
Publikováno v:
Human Mutation. 23:245-257
A defective form of the AIRE protein causes autoimmune destruction of target organs by disturbing the immunological tolerance of patients with a rare monogenic disease, autoimmune polyendocrinopathy (APE)-candidiasis (C)-ectodermal dystrophy (ED), AP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ff571613da8fab0963e1004a7ba292
https://doi.org/10.1002/humu.20003
https://doi.org/10.1002/humu.20003
Publikováno v:
Cancer Genetics and Cytogenetics. 146:89-101
Expression analysis of apoptotic genes was performed for 15 patients with acute myelocytic leukemia (AML) at the time of diagnosis to identify genes and signaling pathways involved in the regulation of cell survival and apoptosis during leukemogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f01c4b9e6f4368b285c3bdc81f1e8d
https://doi.org/10.1016/s0165-4608(03)00102-x
https://doi.org/10.1016/s0165-4608(03)00102-x
Autor:
Mauno Vihinen, Juha Ollila
Publikováno v:
Genes & Immunity. 4:343-350
The development of adaptive immunity and responses to foreign molecules and organisms relies on the highly regulated production of hundreds of proteins. B-cell maturation, from committed progenitors to terminally differentiated plasma cells, is a mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d96554e64c27e71c35639e9f1fb149
https://doi.org/10.1038/sj.gene.6363974
https://doi.org/10.1038/sj.gene.6363974
Autor:
Kazunori Shibuya, Juha Ollila, Jun Kudoh, Ai Shintani, Maarit Heino, Nobuyoshi Shimizu, Mauno Vihinen, Hamish S. Scott, Pärt Peterson, Shinsei Minoshima, Ulla Aapola, Kai Krohn, Stylianos E. Antonarakis, Kazuhiko Kawasaki
Publikováno v:
Genomics, Vol. 65, No 3 (2000) pp. 293-298
We have isolated the DNMT3L gene that is related to the cytosine-5-methyltransferase 3 (DNMT3) family. The gene is located on chromosome 21q22.3 between the AIRE and the KIAA0653 genes and spans approximately 16 kb of genomic sequence. The encoded pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b23958df0f3970bdb586da0411c986
https://doi.org/10.1006/geno.2000.6168
https://doi.org/10.1006/geno.2000.6168
Publikováno v:
Karolinska Institutet
Immunodeficiencies form a distinct group of human hereditary diseases with several rare disorders. During recent years, information has been collected concerning immunodeficiency patients and mutations causing disorders. The large European (ESID) reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4b3b73f4f0b41a5eb635263ab4ac0e
https://doi.org/10.1002/(sici)1098-1004(1997)10:4<261::aid-humu1>3.0.co
https://doi.org/10.1002/(sici)1098-1004(1997)10:4<261::aid-humu1>3.0.co