Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Juha Okkeri"'
Autor:
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Tumour suppressors are inhibited in cancers and their reactivation could provide novel therapy opportunities. Here, the authors study the structural mechanism by which human tumour suppressor Protein Phosphatase 2A is inhibited in breast cancer cells
Externí odkaz:
https://doaj.org/article/a40d0289287e4365ac202e20daf82ec2
Autor:
Kevin Myant, Xi Qiao, Tuuli Halonen, Christophe Come, Anni Laine, Mahnaz Janghorban, Johanna I. Partanen, John Cassidy, Erinn-Lee Ogg, Patrizia Cammareri, Tiina Laiterä, Juha Okkeri, Juha Klefström, Rosalie C. Sears, Owen J. Sansom, Jukka Westermarck
Publikováno v:
Cell Reports, Vol 12, Iss 6, Pp 1019-1031 (2015)
An understanding of the mechanisms determining MYC’s transcriptional and proliferation-promoting activities in vivo could facilitate approaches for MYC targeting. However, post-translational mechanisms that control MYC function in vivo are poorly u
Externí odkaz:
https://doaj.org/article/9192a9a0cda04901aa08c766517eccaa
Autor:
Anchit Khanna, Juha Okkeri, Turker Bilgen, Timo Tiirikka, Mauno Vihinen, Tapio Visakorpi, Jukka Westermarck
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17979 (2011)
EGFR-MEK-ERK signaling pathway has an established role in promoting malignant growth and disease progression in human cancers. Therefore identification of transcriptional targets mediating the oncogenic effects of the EGFR-MEK-ERK pathway would be hi
Externí odkaz:
https://doaj.org/article/0644c9972f2b408aa3b9832ede5ab4ec
Autor:
Zhizhi Wang, Otto Kauko, Karolina Pavic, Wenqing Xu, Grzegorz Sarek, Tuuli Halonen, Jiao Wang, Juha Okkeri, Zihe Rao, Jukka Westermarck, Päivi M. Ojala
Publikováno v:
EMBO reports. 18:437-450
Protein phosphatase 2A (PP2A) is a critical human tumor suppressor. Cancerous inhibitor of PP2A (CIP2A) supports the activity of several critical cancer drivers (Akt, MYC, E2F1) and promotes malignancy in most cancer types via PP2A inhibition. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d2d7dc5b011b4090e7740abb5aea75
https://doi.org/10.15252/embr.201642788
https://doi.org/10.15252/embr.201642788
Autor:
Juha Okkeri, Tuomas Haltia
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1757(11):1485-1495
ZntA is a P-type ATPase which transports Zn 2+ , Pb 2+ and Cd 2+ out of the cell. Two cysteine-containing motifs, CAAC near the N-terminus and CPC in transmembrane helix 6, are involved in binding of the translocated metal. We have studied these moti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca1b329dfbfd40ee72f3958c8bad2ee
Publikováno v:
Biochemical Journal. 377:95-105
In P-type ATPases, the nucleotide-binding (N) domain is located in the middle of the sequence which folds into the phosphorylation (P) domain. The N domain of ZntA, a Zn2+-translocating P-type ATPase from Escherichia coli, is approx. 13% identical wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76825d7c289c2c3f1b3c5128e10dffbd
https://doi.org/10.1042/bj20030740
https://doi.org/10.1042/bj20030740
Autor:
Philip Coffino, Jens Laitinen, Kristiina Järvinen, Merja Auvinen, Kari Alitalo, Leif C. Andersson, Anneli Hotti, Erkki Hölttä, Olli A. Jänne, Juha Okkeri, Mathias Bergman
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 35:496-521
c-Myc is an oncogenic transcription factor involved in the regulation of cell proliferation, differentiation and apoptosis. The direct targets of c-Myc mediating these various processes are slowly being unravelled. This study indicates that the ornit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43aad1af07351d48a5c14850a7da1751
https://doi.org/10.1016/s1357-2725(02)00305-9
https://doi.org/10.1016/s1357-2725(02)00305-9
Autor:
Kevin Myant, Tuuli Halonen, Erinn Lee Ogg, John W. Cassidy, Anni Laine, Tiina Laiterä, Rosalie C. Sears, Mahnaz Janghorban, Jukka Westermarck, Owen J. Sansom, Christophe Côme, Juha Klefström, Johanna I. Partanen, Juha Okkeri, Xi Qiao, Patrizia Cammareri
Publikováno v:
Cell Reports, Vol 12, Iss 6, Pp 1019-1031 (2015)
Myant, K, Qiao, X, Halonen, T, Come, C, Laine, A, Janghorban, M, Partanen, J, Cassidy, J, Ogg, E, Cammareri, P, Laiterä, T, Okkeri, J, Klefström, J, Sears, R, Sansom, O & Westermarck, J 2015, ' Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation ', Cell Reports, vol. 12, no. 6, pp. 1019-1031 . https://doi.org/10.1016/j.celrep.2015.07.003
Myant, K, Qiao, X, Halonen, T, Come, C, Laine, A, Janghorban, M, Partanen, J, Cassidy, J, Ogg, E, Cammareri, P, Laiterä, T, Okkeri, J, Klefström, J, Sears, R, Sansom, O & Westermarck, J 2015, ' Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation ', Cell Reports, vol. 12, no. 6, pp. 1019-1031 . https://doi.org/10.1016/j.celrep.2015.07.003
An understanding of the mechanisms determining MYC's transcriptional and proliferation-promoting activities in vivo could facilitate approaches for MYC targeting. However, post-translational mechanisms that control MYC function in vivo are poorly und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82131f1b06b1e00aa470a63c57e9ae59
https://pubmed.ncbi.nlm.nih.gov/26235622
https://pubmed.ncbi.nlm.nih.gov/26235622
Autor:
Kevin Myant, Christophe Côme, Anni Laine, Tuuli Halonen, Tiina Laiterä, Owen J. Sansom, Jukka Westermarck, Mahnaz Janghorban, Juha Klefström, Xi Qiao, Johanna I. Partanen, Rosalie C. Sears, Erinn-Lee Ogg, Juha Okkeri
Publikováno v:
Molecular Cancer Research. 13:PR03-PR03
Targeting MYC function would be highly desirable for hyperproliferative diseases. As MYC itself is refractory to direct chemical inhibition, understanding of the mechanisms determining MYC's transcriptional and proliferation promoting activities in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2954962858272d03f9b1666967b2cd01
https://doi.org/10.1158/1557-3125.myc15-pr03
https://doi.org/10.1158/1557-3125.myc15-pr03
Autor:
Juha Okkeri, Tuomas Haltia
Publikováno v:
Biochemistry. 38:14109-14116
Cation-transporting P-type ATPases comprise a major membrane protein family, the members of which are found in eukaryotes, eubacteria, and archaea. A phylogenetically old branch of the P-type ATPase family is involved in the transport of heavy-metal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347fb496ddfd2186a25c1ae11be8d11c
https://doi.org/10.1021/bi9913956
https://doi.org/10.1021/bi9913956