Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Juha Muilu"'
2
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy
Autor: Cristina R. Reschke, Junyi Su, Lara S. Costard, R. Jeroen Pasterkamp, Vamshidhar R. Vangoor, Gary P. Brennan, Federico Del Gallo, Tobias Engel, Valentin Neubert, Jochen H. M. Prehn, Aoife Campbell, Dennis Pultz, Lea M. Harder, Janosch P. Heller, Morten T. Venø, Yan Yan, David C. Henshall, Braxton A. Norwood, Jørgen Kjems, Niamh M. C. Connolly, Gareth Morris, Jens S. Andersen, Amaya Sanz-Rodriguez, Elena Langa, Stephanie Schorge, Felix Rosenow, Ajay Pal, Beatrice Salvetti, Karen Conboy, Juha Muilu, Paolo F. Fabene, Sebastian Bauer, Eva M. Jimenez-Mateos, Stefan J. Haunsberger, Amy Richardson
Publikováno v: Venø, M T, Reschke, C R, Morris, G, Connolly, N M C, Su, J, Yan, Y, Engel, T, Jimenez-Mateos, E M, Harder, L M, Pultz, D, Haunsberger, S J, Pal, A, Heller, J P, Campbell, A, Langa, E, Brennan, G P, Conboy, K, Richardson, A, Norwood, B A, Costard, L S, Neubert, V, Gallo, F D, Salvetti, B, Vangoor, V R, Sanz-Rodriguez, A, Muilu, J, Fabene, P F, Pasterkamp, R J, Prehn, J H M, Schorge, S, Andersen, J S, Rosenow, F, Bauer, S, Kjems, J & Henshall, D C 2020, ' A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, pp. 15977-15988 . https://doi.org/10.1073/pnas.1919313117
Proceedings of the National Academy of Sciences
Venø, M T, Reschke, C R, Morris, G, Connolly, N M C, Su, J, Yan, Y, Engel, T, Jimenez-Mateos, E M, Harder, L M, Pultz, D, Haunsberger, S J, Pal, A, Heller, J P, Campbell, A, Langa, E, Brennan, G P, Conboy, K, Richardson, A, Norwood, B A, Costard, L S, Neubert, V, Del Gallo, F, Salvetti, B, Vangoor, V R, Sanz-Rodriguez, A, Muilu, J, Fabene, P F, Pasterkamp, R J, Prehn, J H M, Schorge, S, Andersen, J S, Rosenow, F, Bauer, S, Kjems, J & Henshall, D C 2020, ' A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 27, 27, pp. 15977-15988 . https://doi.org/10.1073/pnas.1919313117
Proceedings of the National Academy of Sciences of the United States of America
Significance Temporal lobe epilepsy is commonly drug resistant and is associated with dysregulated hippocampal gene expression. MicroRNAs are short noncoding RNAs which control protein levels by binding target mRNAs via Argonaute proteins. We sequenc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef11a947b31811a4b5bce9f9ba6f9dd
https://pure.au.dk/ws/files/224579357/15977.full.pdf
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3
Genetics in an isolated population like Finland: a different basis for genomic medicine?
Autor: Helena Kääriäinen, Markus Perola, Juha Muilu, Kati Kristiansson
Publikováno v: Journal of Community Genetics
A unique genetic background in an isolated population like that of Finland offers special opportunities for genetic research as well as for applying the genetic developments to the health care. On the other hand, the different genetic background may
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e2c7363959299bcef2b9016f3a681f
https://doi.org/10.1007/s12687-017-0318-4
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5
Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data
Autor: Mélanie Courtot, Jeffrey S. Grethe, Helen Parkinson, Stian Soiland-Reyes, Murat Sariyar, Alejandra Gonzalez-Beltran, Chris Morris, Donal Fellows, Camille Laibe, Nicolas Le Novère, Jacky L. Snoep, Maria Jesus Martin, Henning Hermjakob, Johanna McEntyre, Juha Muilu, Natalie J. Stanford, Julie A. McMurry, Sarala M. Wimalaratne, Susanna-Assunta Sansone, Philippe Rocca-Serra, Carole Goble, Jean-Karim Hériché, Melissa A. Haendel, Nathalie Conte, Christopher J. Mungall, Lilly Winfree, Nicole L. Washington, Wolfgang Müller, John Kunze, Janna Hastings, Jon Ison, James Malone, Katherine Wolstencroft, Tony Burdett, Nick Juty, Rafael C. Jimenez, Alan Williams, John Deck, Michel Dumontier, Tom Conlin, Niklas Blomberg, Philipp Gormanns, Neil Swainston, Simon Jupp
Publikováno v: PLOS Biology
PLOS BIOLOGY, 15(6), e2001414
McMurry, JA; Juty, N; Blomberg, N; Burdett, T; Conlin, T; Conte, N; et al.(2017). Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data. PLoS Biology, 15(6). doi: 10.1371/journal.pbio.2001414. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/3ph405fc
PLoS biology, vol 15, iss 6
PLoS Biol. 15:e2001414 (2017)
PLOS BIOLOGY
PLOS BIOLOGY, 15(6):2001414. PUBLIC LIBRARY SCIENCE
PLoS Biology
McMurry, J A, Juty, N, Blomberg, N, Burdett, T, Conlin, T, Conte, N, Courtot, M, Deck, J, Dumontier, M, Fellows, D, Gonzalez-Beltran, A, Gormanns, P, Grethe, J, Hastings, J, Hériché, J-K, Hermjakob, H, Ison, J C, Jimenez, R C, Jupp, S, Kunze, J, Laibe, C, Le Novère, N, Malone, J, Martin, M J, McEntyre, J R, Morris, C, Muilu, J, Müller, W, Rocca-Serra, P, Sansone, S A, Sariyar, M, Snoep, J L, Soiland-Reyes, S, Stanford, N J, Swainston, N, Washington, N, Williams, A R, Wimalaratne, S M, Winfree, L M, Wolstencroft, K, Goble, C, Mungall, C J, Haendel, M A & Parkinson, H 2017, ' Identifiers for the 21st century : How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data. ', PLoS Biology, vol. 15, no. 6, e2001414 . https://doi.org/10.1371/journal.pbio.2001414
McMurry, J A, Juty, N, Blomberg, N, Burdett, T, Conlin, T, Conte, N, Courtot, M, Deck, J, Dumontier, M, Fellows, D K, Gonzalez-Beltran, A, Gormanns, P, Grethe, J, Hastings, J, Hériché, J-K, Hermjakob, H, Ison, J, Jimenez, R C, Jupp, S, Kunze, J, Laibe, C, Le Novère, N, Malone, J, Martin, M J, McEntyre, J R, Morris, C, Muilu, J, Müller, W, Rocca-Serra, P, Sansone, S-A, Sariyar, M, Snoep, J L, Soiland-Reyes, S, Stanford, N J, Swainston, N, Washington, N, Williams, A R, Wimalaratne, S M, Winfree, L M, Wolstencroft, K, Goble, C, Mungall, C J, Haendel, M A & Parkinson, H 2017, ' Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data ', P L o S Biology, vol. 15, no. 6, e2001414 . https://doi.org/10.1371/journal.pbio.2001414
Plos Biology, 15(6):e2001414. Public Library of Science
PLoS Biology, Vol 15, Iss 6, p e2001414 (2017)
In many disciplines, data is highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such databases depends on the discipline of data science and on the humble bricks and mortar th
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6
Observ-OM and Observ-TAB: Universal syntax solutions for the integration, search, and exchange of phenotype and genotype information
Autor: Helen Parkinson, Chao Pang, Erik T. Roos, Vincent Ferretti, Morris A. Swertz, Juha Muilu, Anthony J. Brookes, Kasper Joeri van der Velde, Gudmundur A. Thorisson, Tomasz Adamusiak, Sirisha Gollapudi, Myles Byrne, Hans L. Hillege
Publikováno v: Human Mutation
Human Mutation, 33(5), 867-873. Wiley
Human Mutation; Vol 33
Genetic and epidemiological research increasingly employs large collections of phenotypic and molecular observation data from high quality human and model organism samples. Standardization efforts have produced a few simple formats for exchange of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05bb0f2a1fcb22b527873144a01c5eb
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7
The Phenotype and Genotype Experiment Object Model (PaGE-OM): A Robust Data Structure for Information Related to DNA Variation
Autor: Toshio Kojima, Yasumasa Shigemoto, Martin Senger, Atsuhiro Mukaiyama, Takeshi Tomiki, Matthew Darlison, Mark Woon, Hideaki Sugawara, Haseena Rajeevan, Akihiko Konagaya, Heikki Lehväslaiho, Kimitoshi Naito, Hiroshi Mizushima, David Fredman, Gudmundur A. Thorisson, Juha Muilu, Takashige Oroguchi, Masako Kuroda, Debasis Dash, Ituro Inoue, Albert V. Smith, Anthony J. Brookes
Publikováno v: Human Mutation; Vol 30
Human Mutation
Torrents of genotype-phenotype data are being generated, all of which must be captured, processed, integrated, and exploited. To do this optimally requires the use of standard and interoperable "object models," providing a description of how to parti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c1257d3a66ec04d40a2d32e822d1a0
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8
Geographical structure and differential natural selection amongst North European populations
Autor: Lynn Cherkas, Brian P. McEvoy, Juha Muilu, Jaakko Kaprio, Markus Perola, Nicholas G. Martin, Simon Cronin, Grant W. Montgomery, Dorret I. Boomsma, Tim D. Spector, Kourosh R. Ahmadi, Jouke J. Hottenga, Patrik K. E. Magnusson, Gonneke Willemsen, Ann-Christine Syvänen, Aarno Palotie, Samuli Ripatti, Leena Peltonen, Kauko Heikkilä, Elisabeth Widen, Ulrika Liljedahl, Peter M. Visscher, Kaare Christensen, Orla Hardiman, Nancy L. Pedersen, Kirsten Ohm Kyvik, Allan F. McRae
Publikováno v: McEvoy, B P, Montgomery, GW, McRae, A F, Ripatti, S, Perola, M, Spector, T D, Cherkas, L F, Ahmadi, K, Boomsma, D I, Willemsen, G, Hottenga, J J, Pedersen, N L, Magnusson, P K E, Kyvik, K, Christensen, K, Kaprio, J, Heikkilä, K, Palotie, A, Widen, E, Muilu, J, Syvänen, A C, Liljedahl, U, Hardiman, O, Cronin, S, Peltonen, L, Martin, N G & Visscher, P M 2009, ' Geographical structure and differential natural selection amongst North European populations ', Genome Research, vol. 19, no. 5, pp. 804-814 . https://doi.org/10.1101/gr.083394.108
Genome Research, 19(5), 804-814. Cold Spring Harbor Laboratory Press
McEvoy, B P, Montgomery, G W, McRae, A F, Ripatti, S, Perola, M, Spector, T D, Cherkas, L, Ahmadi, K R, Boomsma, D, Willemsen, G, Hottenga, J J, Pedersen, N L, Magnusson, P K E, Kyvik, K O, Christensen, K, Kaprio, J, Heikkilä, K, Palotie, A, Widen, E, Muilu, J, Syvänen, A-C, Liljedahl, U, Hardiman, O, Cronin, S, Peltonen, L, Martin, N G & Visscher, P M 2009, ' Geographical structure and differential natural selection among North European populations ', Genome Research, vol. 19, no. 5, pp. 804-14 . https://doi.org/10.1101/gr.083394.108
Population structure can provide novel insight into the human past, and recognizing and correcting for such stratification is a practical concern in gene mapping by many association methodologies. We investigate these patterns, primarily through prin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0e3b263d2aebe19ed84602e6efdf7f
https://doi.org/10.1101/gr.083394.108
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9
Data Modeling and Data Communication in GenomEUtwin
Autor: Ann Björklund, Juha Muilu, Nancy L. Pedersen, Anne Leinonen, Jan-Eric Litton
Publikováno v: Twin Research. 6:383-390
Database infrastructure has become a critical component for competitive life sciences research and discovery. The explosion of data requires that the data are properly loaded, accessed, managed, queried, analyzed, and shared with others. The key purp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4b36d191ce3a917e774e7760725d6f
https://doi.org/10.1375/136905203770326385
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10
Ab initio study of small zinc sulfide crystallites
Autor: Juha Muilu, Tapani A. Pakkanen
Publikováno v: Surface Science. 364:439-452
In this work the size evolution of properties of small in vacuo zinc sulfide crystals is studied using the ab initio Hartree-Fock molecular orbital method. The calculations on finite crystallite clusters, ranging from Zn 3 S 3 to Zn 240 S 240 , are m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88f456b6f55b506acaa878f7512c7ddf
https://doi.org/10.1016/0039-6028(96)00633-4
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