Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process

Autor: Antero Salminen, Juha M. T. Hyttinen, Anu Kauppinen, Kai Kaarniranta

Publikováno v: International Journal of Cell Biology, Vol 2012 (2012)

The NF-κB signaling system and the autophagic degradation pathway are crucial cellular survival mechanisms, both being well conserved during evolution. Emerging studies have indicated that the IKK/NF-κB signaling axis regulates autophagy in a conte

Externí odkaz: https://doaj.org/article/982113afe262446ab41dfd9958e47e26

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Autor: Toni Tamminen, Ali Koskela, Elisa Toropainen, Iswariyaraja Sridevi Gurubaran, Mateusz Winiarczyk, Mikko Liukkonen, Jussi J. Paterno, Petri Lackman, Amir Sadeghi, Johanna Viiri, Juha M. T. Hyttinen, Ari Koskelainen, Kai Kaarniranta

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity

Publisher Copyright: © 2021 Toni Tamminen et al. Chronic oxidative stress eventually leads to protein aggregation in combination with impaired autophagy, which has been observed in age-related macular degeneration. We have previously shown an effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab82c487c852ee58dd16b3c0f646a248
https://aaltodoc.aalto.fi/handle/123456789/112590

Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells.

Autor: Johanna Viiri, Marialaura Amadio, Nicoletta Marchesi, Juha M T Hyttinen, Niko Kivinen, Reijo Sironen, Kirsi Rilla, Saeed Akhtar, Alessandro Provenzani, Vito Giuseppe D'Agostino, Stefano Govoni, Alessia Pascale, Hansjurgen Agostini, Goran Petrovski, Antero Salminen, Kai Kaarniranta

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e69563 (2013)

Age-related macular degeneration (AMD) is the most common reason of visual impairment in the elderly in the Western countries. The degeneration of retinal pigment epithelial cells (RPE) causes secondarily adverse effects on neural retina leading to v

Externí odkaz: https://doaj.org/article/d6824d07b1854c9eade85e2d16f9a8be

Pinosylvin-mediated protection against oxidative stress in human retinal pigment epithelial cells

Autor: Ali, Koskela, Mika, Reinisalo, Juha M T, Hyttinen, Kai, Kaarniranta, Reijo O, Karjalainen

Publikováno v: Molecular Vision

Purpose In this work, we investigated the ability of pinosylvin (PS), 3,5-dihydroxy-trans-stilbene, to modulate oxidative stress in human RPE cells. PS, a stilbenoid polyphenol, occurs in high concentrations in bark byproducts and therefore represent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a7fd1852309b8b650bd2bc1d3c2a3130
https://pubmed.ncbi.nlm.nih.gov/24940030

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1α -/- Mouse Model Evoke Complement Component C5a Independent of C3

Autor: Iswariyaraja Sridevi Gurubaran, Hanna Heloterä, Stephen Marry, Ali Koskela, Juha M. T. Hyttinen, Jussi J. Paterno, Arto Urtti, Mei Chen, Heping Xu, Anu Kauppinen, Kai Kaarniranta

Publikováno v: Biology
Volume 10
Issue 7
Sridevi Gurubaran, I, Heloterä, H, Marry, S, Koskela, A, Hyttinen, J M T, Paterno, J J, Urtti, A, Chen, M, Xu, H, Kauppinen, A & Kaarniranta, K 2021, ' Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1α-/-Mouse Model Evoke Complement Component C5a Independent of C3 ', Biology, vol. 10, no. 7, 622 . https://doi.org/10.3390/biology10070622
Biology, Vol 10, Iss 622, p 622 (2021)

Aging-associated chronic oxidative stress and inflammation are known to be involved in various diseases, e.g., age-related macular degeneration (AMD). Previously, we reported the presence of dry AMD-like signs, such as elevated oxidative stress, dysf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9a6f044f3ad392d0b2ae2ad4111b4b1f