Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Juha M. Peltonen"'
Autor:
Juha M. Peltonen, Anne Roivainen, Juha Rouru, Sami Suilamo, Jukka Herttuainen, Iina Volanen, Kirsi A. Virtanen, Juha O. Rinne, Marita Kailajärvi, Jukka Sallinen, Vesa Oikonen, Semi Helin, Johanna Hietamäki, Pauliina Luoto, Jere Virta, Aila Holopainen, Mika Scheinin, Eveliina Arponen
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 41:1947-1956
Purpose 11C-labelled 1-[(S)-1-(2,3-dihydrobenzo[1,2]dioxin-2-yl)methyl]-4-(3-methoxy-methylpyridin-2-yl)-piperazine (11C-ORM-13070) is a novel PET tracer for imaging of α2C-adrenoceptors in the human brain. Brain α2C-adrenoceptors may be therapeuti
Autor:
Marjo Pihlavisto, Henri Xhaard, Anna-Marja Hoffren, Siegfried Wurster, Juha M. Peltonen, Anne Marjamäki, Liisa T. Kanerva, Juha-Matti Savola, Mark S. Johnson, Mika Scheinin, Tommi Nyrönen
Publikováno v:
British Journal of Pharmacology. 140:347-358
The structural determinants of catechol hydroxyl interactions with adrenergic receptors were examined using 12 α2-adrenergic agonists and a panel of mutated human α2A-adrenoceptors. The α2ASer201 mutant had a Cys Ser201 (position 5.43) amino-acid
Autor:
Juha Rouru, Juha M. Peltonen, Semi Helin, Juha O. Rinne, Jukka Sallinen, Anne Roivainen, Iina Volanen, Pauliina Luoto, Jere Virta, Marita Kailajärvi, Johanna Hietamäki, Mika Scheinin, Aila Holopainen, Jussi Lehto, Kirsi A. Virtanen, Eveliina Arponen, Vesa Oikonen
Publikováno v:
European journal of nuclear medicine and molecular imaging. 42(1)
α2C-Adrenoceptors share inhibitory presynaptic functions with the more abundant α2A-adrenoceptor subtype, but they also have widespread postsynaptic modulatory functions in the brain. Research on the noradrenergic system of the human brain has been
Autor:
Pauliina, Luoto, Sami, Suilamo, Vesa, Oikonen, Eveliina, Arponen, Semi, Helin, Jukka, Herttuainen, Johanna, Hietamäki, Aila, Holopainen, Marita, Kailajärvi, Juha M, Peltonen, Juha, Rouru, Jukka, Sallinen, Mika, Scheinin, Jere, Virta, Kirsi, Virtanen, Iina, Volanen, Anne, Roivainen, Juha O, Rinne
Publikováno v:
European journal of nuclear medicine and molecular imaging. 41(10)
(11)C-labelled 1-[(S)-1-(2,3-dihydrobenzo[1,2]dioxin-2-yl)methyl]-4-(3-methoxy-methylpyridin-2-yl)-piperazine ((11)C-ORM-13070) is a novel PET tracer for imaging of α2C-adrenoceptors in the human brain. Brain α2C-adrenoceptors may be therapeutic ta
Autor:
Liisa Pylkkänen, Christer T. Jansén, Juha M. Peltonen, Jarmo Laihia, Terhi Lehtinen, Lasse Leino, Iina Volanen
Publikováno v:
Acta dermato-venereologica. 94(4)
New treatment modalities are needed in atopic dermatitis. We evaluated the pharmacokinetics, safety, tolerability, and efficacy of topical cis-urocanic acid (cis-UCA) cream in randomised vehicle-controlled double-blinded clinical trials. The subjects
Publikováno v:
European Journal of Pharmacology. 355:275-279
We measured agonist-stimulated binding of the stable GTP-analog guanosine-5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS) as a functional assay to monitor G-protein activation by recombinant human alpha2-adrenoceptor subtypes alpha2A, alpha2B and alp
Autor:
Juha M, Peltonen, Tommi, Nyrönen, Siegfried, Wurster, Marjo, Pihlavisto, Anna-Marja, Hoffrén, Anne, Marjamäki, Henri, Xhaard, Liisa, Kanerva, Juha-Matti, Savola, Mark S, Johnson, Mika, Scheinin
Publikováno v:
British journal of pharmacology. 140(2)
1. The structural determinants of catechol hydroxyl interactions with adrenergic receptors were examined using 12 alpha2-adrenergic agonists and a panel of mutated human alpha2A-adrenoceptors. The alpha2ASer201 mutant had a Cys --Ser201 (position 5.4
Autor:
Juha M. Peltonen, Anne Marjamäki, Liisa T. Kanerva, Tiina A. Salminen, Tommi Nyrönen, Mika Scheinin, Erja Katainen, Siegfried Wurster, Minna Varis, Mark S. Johnson, Juha-Matti Savola, Marjo Pihlavisto, Anna-Marja Hoffren, Leif Laaksonen
Publikováno v:
ResearcherID
Europe PubMed Central
Europe PubMed Central
We present a mechanism for agonist-promoted alpha(2A)-adrenergic receptor (alpha(2A)-AR) activation based on structural, pharmacological, and theoretical evidence of the interactions between phenethylamine ligands and alpha(2A)-AR. In this study, we