Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Juha Lauren"'
Autor:
Henri J. Huttunen, Tiina Laakso, Matti S. Airaksinen, Pranuthi Muggalla, Juha Lauren, Kai Kysenius, Anja O. Paatero
Publikováno v:
Journal of Alzheimer's Disease. 31:759-764
Neuronal LRRTM3 (leucine-rich repeat transmembrane 3) protein has been reported to promote amyloid-β protein precursor (AβPP) processing and LRRTM3 is a candidate gene in late-onset Alzheimer's disease. To address the role of LRRTM3 in AβPP proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9244eb885e257f000a73cd67c76333d
https://doi.org/10.3233/jad-2012-120193
https://doi.org/10.3233/jad-2012-120193
Publikováno v:
Azania: Archaeological Research in Africa. 44:163-193
During the 1980s, a fairly detailed picture was constructed of the prehistory of the Loita-Mara region, Narok District, southwestern Kenya, up to Elmenteitan times. However, the archaeological sequence after the Elmenteitan period remained poorly und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8c580bbc588bd896c6807cd6783efe0
https://doi.org/10.1080/00671990903047090
https://doi.org/10.1080/00671990903047090
Publikováno v:
Nature
A pathological hallmark of Alzheimer's disease is an accumulation of insoluble plaque containing the amyloid-beta peptide of 40-42 amino acid residues. Prefibrillar, soluble oligomers of amyloid-beta have been recognized to be early and key intermedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e026adf2646703529d4479acf5c10d1c
http://europepmc.org/articles/PMC2748841
http://europepmc.org/articles/PMC2748841
Autor:
Amy F.T. Arnsten, Ji Liao, Althea A. Stillman, Fuki M. Hisama, Samuel G. B. Johnson, James H. Park, Betty P. Liu, Aaron W. McGee, Stephane Budel, Stefano Sodi, Bao-Zhu Yang, Thihan Padukkavidana, Zeny Feng, Jieun Kim, Fenghua Hu, Juha Lauren, Joel Gelernter, Hongyu Zhao, Stephen M. Strittmatter
Publikováno v:
The Journal of Neuroscience. 28:13161-13172
In schizophrenia, genetic predisposition has been linked to chromosome 22q11 and myelin-specific genes are misexpressed in schizophrenia. Nogo-66 receptor 1 (NGRorRTN4R) has been considered to be a 22q11 candidate gene for schizophrenia susceptibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02071b1803da2b18b9f61c485f66768
https://doi.org/10.1523/jneurosci.3828-08.2008
https://doi.org/10.1523/jneurosci.3828-08.2008
Autor:
Juha Lauren, Jaan-Olle Andressoo, Mart Saarma, Raimo K. Tuominen, Johan Peränen, Veli-Matti Leppänen, Merja H. Voutilainen, Nisse Kalkkinen, Tõnis Timmusk, Maria Lindahl, Päivi Lindholm, Sanna Janhunen
Publikováno v:
Nature. 448:73-77
In Parkinson's disease, brain dopamine neurons degenerate most prominently in the substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of neurons in developing and adult vertebrate nervous system. The most potent n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107f7acbdcb36ede984f5e2c7e23eca8
https://doi.org/10.1038/nature05957
https://doi.org/10.1038/nature05957
Publikováno v:
Journal of Biological Chemistry. 282:5715-5725
Nogo, MAG, and OMgp are myelin-associated proteins that bind to a neuronal Nogo-66 receptor (NgR/NgR1) to limit axonal regeneration after central nervous system injury. Within Nogo-A, two separate domains are known interact with NgR1. NgR1 is the fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26f58936d1b58f826a56eedea7c82f3
https://doi.org/10.1074/jbc.m609797200
https://doi.org/10.1074/jbc.m609797200
Publikováno v:
Genomics. 81:411-421
Leucine-rich repeat containing proteins are involved in protein-protein interactions and they regulate numerous cellular events during nervous system development and disease. Here we have isolated and characterized a new four-membered family of genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfea22bca26935240ecf8dbc2afc231c
https://doi.org/10.1016/s0888-7543(03)00030-2
https://doi.org/10.1016/s0888-7543(03)00030-2
Publikováno v:
The American Journal of Pathology. 153:1333-1339
Almost all functional cells are located within 30 μm of a blood capillary. Acute changes in blood flow are regulated in response to tissue needs by changes in the constriction level of blood vessels, 1 whereas long-term regulation of tissue perfusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f0e83f49221bfc59cc7c278db9c3038
https://doi.org/10.1016/s0002-9440(10)65717-3
https://doi.org/10.1016/s0002-9440(10)65717-3
Autor:
Juha Lauren
Publikováno v:
Journal of Alzheimer's disease : JAD. 38(2)
Soluble oligomeric species of amyloid-β (Aβ) peptide are presumed to be drivers of synaptic impairment, and the resulting cognitive dysfunction in Alzheimer's disease. In 2009, cellular prion protein (PrPC) was identified in a genome-wide screen as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a92bb8e4287991e8859096d1cad0c09
https://pubmed.ncbi.nlm.nih.gov/23948943
https://pubmed.ncbi.nlm.nih.gov/23948943
Autor:
Juha Lauren, Vootele Voikar, Tiina Laakso, Natalia Kulesskaya, Matti S. Airaksinen, Stephen M. Strittmatter
Publikováno v:
Behavioural brain research. 238
The LRRTM family proteins have been shown to act as synaptogenic cell adhesion molecules via interaction with presynaptic neurexins and are associated with neuropsychiatric disorders. LRRTM1-knockout mice have subtle morphological deficits in excitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e17a30c2d759a8776971fbd3422f967
https://pubmed.ncbi.nlm.nih.gov/23089646
https://pubmed.ncbi.nlm.nih.gov/23089646