Fatigue, residual strength and non-destructive tests of an aging aircraft’s wing detail

Autor: Keijo Koski, Matti Sarkimo, Juha Juntunen, Kari Lahdenperä, Sauli Liukkonen, Aslak Siljander, Jarkko Tikka, Mika Bäckström, R. Lahtinen

Publikováno v: Koski, K, Siljander, A, Bäckström, M, Liukkonen, S, Juntunen, J, Sarkimo, M, Lahdenperä, K, Tikka, J & Lahtinen, R 2009, ' Fatigue, residual strength and non-destructive tests of an aging aircraft's wing detail ', International Journal of Fatigue, vol. 31, no. 6, pp. 1089-1094 . https://doi.org/10.1016/j.ijfatigue.2008.05.015

This study concentrates on fatigue, residual strength and non-destructive tests of an aging aircraft’s wing detail of the Finnish Air Force’s Hawk Mk.51 jet trainer. The studied detail was the integral stiffener with a drain hole near the wing ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9fbd89d176dc9365bb04f84eb596400
https://doi.org/10.1016/j.ijfatigue.2008.05.015

The effect of water solubility of solutes on their flux through human skin in vitro: A prodrug database integrated into the extended Flynn database

Autor: Kenneth B. Sloan, Susruta Majumdar, Juha Juntunen

Publikováno v: International Journal of Pharmaceutics. 351:92-103

A database ( n = 50) consisting of values of solubility in water, S AQ , solubility in octanol, S OCT , molecular weight, MW, and maximum flux based on the delivery of total species containing a parent drug by its prodrugs through human skin in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1b602cca04e58722015a6547395899
https://doi.org/10.1016/j.ijpharm.2007.09.034

Anandamide prodrugs

Autor: Juha Juntunen, Tapio Nevalainen, Juhani Huuskonen, Krista Laine, Riku Niemi, David W. Pate, Hannu Taipale, Tomi Järvinen

Publikováno v: European Journal of Pharmaceutical Sciences. 19:37-43

Phosphate esters of arachidonylethanolamide (AEA) and R-methanandamide were synthesized and evaluated as water-soluble prodrugs. Various physicochemical properties (pKa, partition coefficient, aqueous solubility) were determined for the synthesized p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5e9f26ace2b973dfa4f2dfe85ad885a
https://doi.org/10.1016/s0928-0987(03)00044-7

In-vitro corneal permeation of cannabinoids and their water-soluble phosphate ester prodrugs

Autor: Riku Niemi, Tomi Järvinen, Juha Juntunen

Publikováno v: The Journal of pharmacy and pharmacology. 57(9)

Topically administered cannabinoids have been shown to reduce intraocular pressure by interacting with the ocular cannabinoid receptor. Most cannabinoids have very poor aqueous solubility, which limits their pharmaceutical development and usefulness.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4334cce44d724f8f97c81df59e10a7
https://pubmed.ncbi.nlm.nih.gov/16105235

Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid

Autor: Séverine Vandevoorde, Kent-Olov Jonsson, Jeffrey C. Jerman, Darren Smart, Didier M. Lambert, Tomi Järvinen, Anna Andersson, Christopher J. Fowler, Juha Juntunen

Publikováno v: Biochemical pharmacology. 66(5)

It has previously been shown that the endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) inhibit the proliferation of C6 glioma cells in a manner that can be prevented by a combination of capsazepine (Caps) and cannabinoid (CB) receptor an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c288cc558e697222e65b2608457416
https://pubmed.ncbi.nlm.nih.gov/12948856