Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Juha Akkila"'
Publikováno v:
European Journal of Pharmacology. 653:70-74
Significant inter-individual variability exists in responses of human dorsal hand veins to activation of α-adrenoceptors. Simultaneous graded infusions of the α1- and α2-adrenoceptor agonists phenylephrine (3.66–8000 ng/min) and dexmedetomidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df527be0b96ad27a7233ccccfbfdbc3
https://doi.org/10.1016/j.ejphar.2010.11.024
https://doi.org/10.1016/j.ejphar.2010.11.024
Autor:
Arvo Mesikepp, Jaan Eha, Lasse Lehtonen, Saila Antila, Ulle Planken, Marika Heinpalu, Pentti Põder, Juha Akkila, Imbrit Loogna
Publikováno v:
Cardiovascular Drugs and Therapy. 17:451-458
Objective: The aim was to study the pharmacodynamic interactions and safety of the co-administration of the calcium sensitizer levosimendan and the calcium antagonist felodipine in patients with coronary heart disease (CHD) and with normal ejection f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b83d0902fa165632e040031ff71594
https://doi.org/10.1023/b:card.0000015860.08185.6d
https://doi.org/10.1023/b:card.0000015860.08185.6d
Autor:
Juhani Knuuti, Lasse Lehtonen, Hidehiro Iida, Kjell Någren, Juha Akkila, Pertti Lehikoinen, Markku Saraste, Liisa-Maria Voipio-Pulkki, Meri Karanko, Heikki Ukkonen
Publikováno v:
Clinical Pharmacology & Therapeutics. 68:522-531
Aims Levosimendan, a novel calcium-dependent calcium sensitizer of the myocardial contractile proteins, also enhances diastolic relaxation and induces peripheral vasodilation by opening potassium channels. To assess the combined energetical effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91df5d8022a063ccaffbada0222e5b73
https://doi.org/10.1067/mcp.2000.110972
https://doi.org/10.1067/mcp.2000.110972
Autor:
Franz X. Kleber, Veselin Mitrovic, Markku S. Nieminen, Lasse Lehtonen, Gerd Hasenfuss, Juha Akkila, Willem J. Remme, Olof Nyquist
Publikováno v:
Journal of the American College of Cardiology. 36:1903-1912
OBJECTIVESWe sought to define the therapeutic dose range of levosimendan in patients with New York Heart Association class II-IV heart failure of ischemic origin.BACKGROUNDLevosimendan is a calcium sensitizer for treatment of acute decompensated hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c386a65291d96abcd323c135b251f97
https://doi.org/10.1016/s0735-1097(00)00961-x
https://doi.org/10.1016/s0735-1097(00)00961-x
Publikováno v:
Journal of Cardiovascular Pharmacology. 35:664-669
Provocation of fatal cardiac arrhythmias has limited the use of inotropic agents as heart failure therapy. Calcium sensitization of the myofilaments might increase inotropy without influencing cardiac electrophysiology unless modified by ancillary pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9423ccd678c5186bce6b2728a68894c1
https://doi.org/10.1097/00005344-200004000-00021
https://doi.org/10.1097/00005344-200004000-00021
Publikováno v:
Cancer Letters. 144:75-84
The levels of 26 kDa-soluble (S) and 30 kDa-membrane-bound (MB) catechol-O-methyltransferase (COMT) polypeptides were determined in paired samples from normal and neoplastic breast tissue of 32 patients with breast cancer. Immunohistochemical stainin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73109b4e59ff2bc146b8b1d09073b415
https://doi.org/10.1016/s0304-3835(99)00197-4
https://doi.org/10.1016/s0304-3835(99)00197-4
Autor:
M. Juhani Knuuti, Juha Akkila, Pertti Lehikoinen, Markku Saraste, Kjell Någren, Liisa-Maria Voipio-Pulkki, Lasse Lehtonen, Heikki Ukkonen
Publikováno v:
Clinical Pharmacology & Therapeutics. 61:596-607
Dynamic positron emission tomography (PET) with [11C]acetate allows noninvasive assessment of myocardial oxygen consumption. In combination with echocardiography, PET enables determination of cardiac efficiency (defined as useful cardiac work per uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d934723a598bf8afb4448cc1fa0cf0f4
https://doi.org/10.1016/s0009-9236(97)90139-9
https://doi.org/10.1016/s0009-9236(97)90139-9
Publikováno v:
European journal of pharmacology. 653(1-3)
Significant inter-individual variability exists in responses of human dorsal hand veins to activation of α-adrenoceptors. Simultaneous graded infusions of the α₁- and α₂-adrenoceptor agonists phenylephrine (3.66-8000 ng/min) and dexmedetomidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f08d6d7a4850ed478be4c69739999574
https://pubmed.ncbi.nlm.nih.gov/21147097
https://pubmed.ncbi.nlm.nih.gov/21147097
Autor:
Juha Akkila, Aulikki Nissinen, Martine Wahl, Pekka Puska, Ingela Wiklund, Adrian Wilson, Timo Lahti
Publikováno v:
Journal of Clinical Epidemiology. 44:989-997
A total of 112 male patients with severe effort-induced angina pectoris (New York Heart Association functional classes II and III) participated in a randomized open trial consisting of a 6 month phase with 3 month treatment cross-overs. The aim of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a1ab52efa722f6dd6354012489aab9
https://doi.org/10.1016/0895-4356(91)90070-p
https://doi.org/10.1016/0895-4356(91)90070-p
Publikováno v:
Clinical Pharmacology and Therapeutics. 48:356-364
The effect of catechol-O-methyltransferase inhibition with nitecapone (OR-462) on the hemodynamic responses to exercise and catecholamine metabolism was studied in 10 healthy male volunteers (aged 19 to 26 years). Nitecapone, a new specific and selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e549f1e0f60919bb33d8f917c702f03
https://doi.org/10.1038/clpt.1990.163
https://doi.org/10.1038/clpt.1990.163