Výsledky vyhledávání - "Juha, Kesseli"

Akademický článek

Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland

Autor: Riikka Nurminen, Ebrahim Afyounian, Niina Paunu, Riku Katainen, Mari Isomäki, Anssi Nurminen, Mauro Scaravilli, Jenni Tolppanen, Vidal Fey, Anni Kivinen, Pauli Helén, Niko Välimäki, Juha Kesseli, Lauri A. Aaltonen, Hannu Haapasalo, Matti Nykter, Kirsi J. Rautajoki

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Predisposing factors underlying familial aggregation of non-syndromic gliomas are still to be uncovered. Whole-exome sequencing was performed in four Finnish families with brain tumors to identify rare predisposing variants. A total of 417 d

Externí odkaz: https://doaj.org/article/3f05e1aae8db4dccab392f0bae132f55

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Akademický článek

Functional human cell-based vascularised cardiac tissue model for biomedical research and testing

Autor: Maria Koivisto, Tuomas A. Tolvanen, Tarja Toimela, Ilkka Miinalainen, Antti Kiviaho, Juha Kesseli, Matti Nykter, Lauri Eklund, Tuula Heinonen

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC) are widely used in in vitro biomedical research and testing. However, fully matured, adult cardiomyocyte characteristics have not been achieved. To improve the maturity

Externí odkaz: https://doaj.org/article/e91a2ccd543946a4a1e74761627a9c6c

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Akademický článek

Adaptive and non-adaptive gene expression responses in prostate cancer during androgen deprivation.

Autor: Reetta Nätkin, Pasi Pennanen, Heimo Syvälä, Merja Bläuer, Juha Kesseli, Teuvo L J Tammela, Matti Nykter, Teemu J Murtola

Publikováno v: PLoS ONE, Vol 18, Iss 2, p e0281645 (2023)

Androgen deprivation therapy is the cornerstone treatment of advanced prostate cancer. Eventually prostate cancer cells overcome androgen deprivation therapy, giving rise to castration resistant prostate cancer (CRPC) characterized by increased andro

Externí odkaz: https://doaj.org/article/9203e67f881845b9a88f84cbfa676d4a

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Akademický článek

Combined Longitudinal Clinical and Autopsy Phenomic Assessment in Lethal Metastatic Prostate Cancer: Recommendations for Advancing Precision Medicine

Publikováno v: European Urology Open Science, Vol 30, Iss , Pp 47-62 (2021)

Background: Systematic identification of data essential for outcome prediction in metastatic prostate cancer (mPC) would accelerate development of precision oncology. Objective: To identify novel phenotypes and features associated with mPC outcome, a

Externí odkaz: https://doaj.org/article/11491b30f8294e5aade6fdfb5c1a7835

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Nonmalignant AR-positive prostate epithelial cells and cancer cells respond differently to androgen

Autor: Konsta Kukkonen, Bryn Autio-Kimura, Hanna Rauhala, Juha Kesseli, Matti Nykter, Leena Latonen, Tapio Visakorpi

Publikováno v: Endocrine-Related Cancer. 29:717-733

Prostate cancer research suffers from the lack of suitable models to study the role of normal cells in prostate carcinogenesis. To address this challenge, we developed a cell line model mimicking luminal prostate epithelial cells by modifying the imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96169737a889663a2e8605196e2358ef
https://doi.org/10.1530/erc-22-0108

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Akademický článek

Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas

Autor: Birgitta Lehtinen, Annina Raita, Juha Kesseli, Matti Annala, Kristiina Nordfors, Olli Yli-Harja, Wei Zhang, Tapio Visakorpi, Matti Nykter, Hannu Haapasalo, Kirsi J. Granberg

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)

Abstract Background Fibroblast growth factor receptors (FGFRs) are well-known proto-oncogenes in several human malignancies and are currently therapeutically targeted in clinical trials. Among glioma subtypes, activating FGFR1 alterations have been o

Externí odkaz: https://doaj.org/article/6b146cdd7b804c81a39d40ca1851b35f

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Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems

Autor: Sara Hamis, Panu Somervuo, J. Arvid Ågren, Dagim Shiferaw Tadele, Juha Kesseli, Jacob G. Scott, Matti Nykter, Philip Gerlee, Dmitri Finkelshtein, Otso Ovaskainen

Theoretical and applied cancer studies that use individual-based models (IBMs) have been limited by the lack of a mathematical formulation that enables rigorous analysis of these models. However, spatial cumulant models (SCMs), which have arisen from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c251dc2accf610ff1d9c1a0d1f2f98a
http://hdl.handle.net/10138/357583

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Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases

Autor: Mina Sattari, Annika Kohvakka, Elaheh Moradi, Hanna Rauhala, Henna Urhonen, William B Isaacs, Matti Nykter, Teemu J Murtola, Teuvo L. J. Tammela, Leena Latonen, G. Steven Bova, Juha Kesseli, Tapio Visakorpi

Publikováno v: Endocrine-Related Cancer.

Prostate cancer (PCa) is the second-most common cause of male cancer-related death in western industrialized countries, and the emergence of metastases is a key challenge in the treatment of PCa. Accumulating studies have shown that long noncoding RN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46442bb6f60ac48db39285c6d5c29c00
https://doi.org/10.1530/erc-22-0247

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