Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Jugal Kishore Das"'
Autor:
Hao-Yun Peng, Liqing Wang, Jugal Kishore Das, Anil Kumar, Darby J. Ballard, Yijie Ren, Xiaofang Xiong, Paul de Figueiredo, Jin-Ming Yang, Jianxun Song
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8+ T cells and has important imp
Externí odkaz:
https://doaj.org/article/2af97a96aeb14b708a623902a676224f
Autor:
Julia Plocica, Fengguang Guo, Jugal Kishore Das, Koichi S. Kobayashi, Thomas A. Ficht, Robert C. Alaniz, Jianxun Song, Paul de Figueiredo
Publikováno v:
Journal of Translational Autoimmunity, Vol 6, Iss , Pp 100198- (2023)
Autoimmune diseases such as rheumatoid arthritis and type 1 diabetes are increasingly common global problems. Concerns about increases in the prevalence of such diseases and the limited efficacy of conventional treatment regimens necessitates new the
Externí odkaz:
https://doaj.org/article/8da82bd35dfb461283b54c870da9d9d2
Autor:
Jugal Kishore Das, Fengguang Guo, Carrie Hunt, Shelby Steinmeyer, Julia A Plocica, Koichi S. Kobayashi, Yufang Ding, Arul Jayaraman, Thomas A Ficht, Robert C. Alaniz, Paul de Figueiredo, Jianxun Song
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Immunotherapy has led to impressive advances in the treatment of autoimmune and pro-inflammatory disorders; yet, its clinical outcomes remain limited by a variety of factors including the pro-inflammatory microenvironment (IME). Discovering effective
Externí odkaz:
https://doaj.org/article/b23a1d9e8ee941c29942432317185d80
Autor:
Liqing Wang, Hao-Yun Peng, Aspen Pham, Eber Villazana, Darby J. Ballard, Jugal Kishore Das, Anil Kumar, Xiaofang Xiong, Jianxun Song
Publikováno v:
Pathogens, Vol 12, Iss 2, p 321 (2023)
For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T cells, have been extensively investigated in regard to SARS-CoV-2 infection. However, human health and T cell responses are also impa
Externí odkaz:
https://doaj.org/article/ba71006973af45b6a1a859c3fbb71d9c
Autor:
Darby J. Ballard, Hao-Yun Peng, Jugal Kishore Das, Anil Kumar, Liqing Wang, Yijie Ren, Xiaofang Xiong, Xingcong Ren, Jin-Ming Yang, Jianxun Song
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Eukaryotic Elongation Factor-2 Kinase (eEF2K) acts as a negative regulator of protein synthesis, translation, and cell growth. As a structurally unique member of the alpha-kinase family, eEF2K is essential to cell survival under stressful conditions,
Externí odkaz:
https://doaj.org/article/1b565e457eea44d3b1b45122df3841bc
Autor:
Liqing Wang, Anil Kumar, Jugal Kishore Das, Yijie Ren, Hao-Yun Peng, Darby Jane Ballard, Xiaofang Xiong, Jacob Rance Davis, Xingcong Ren, Jin-Ming Yang, Jianxun Song
Publikováno v:
Viruses, Vol 14, Iss 8, p 1713 (2022)
Nucleus accumbens-associated protein 1 (NAC1) is a transcription co-factor that has been shown to possess multiple roles in stem cell and cancer biology. However, little is known about its roles in regulation of the immune system. In the current stud
Externí odkaz:
https://doaj.org/article/43088b5d6bae4b5380ee1e5bf389e573
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100264- (2021)
Summary: In T cell-based cancer immunotherapy, tumor antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) can specifically target tumor Ags on malignant cells. This promising approach drove us to adopt this strategy of T cell transfer (ACT)-base
Externí odkaz:
https://doaj.org/article/c707f7872a72461ba0a0ad145c3eb5ce
Autor:
Hao-Yun Peng, Jason Lucavs, Darby Ballard, Jugal Kishore Das, Anil Kumar, Liqing Wang, Yijie Ren, Xiaofang Xiong, Jianxun Song
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T cells undergo metabolic reprogramming and multiple biological processes to satisfy their energetic and biosynthetic demands throughout their lifespan. Several of these metabolic pathways result in the generation of reactive oxygen species (ROS). Th
Externí odkaz:
https://doaj.org/article/98650df419f54f90b6ee0fa5ca41fdc6
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Chimeric antigen receptor (CAR) T (CAR-T) cell transfer has made great success in hematological malignancies, but only shown a limited effect on solid tumors. One of the major hurdles is the poor persistence of infused cells derived from ex vivo acti
Externí odkaz:
https://doaj.org/article/04fcfdea226549dfb42c8729639a9958
Autor:
Mohammad Haque, Fengyang Lei, Xiaofang Xiong, Yijie Ren, Anil Kumar, Jugal Kishore Das, Xingcong Ren, Deyu Fang, Paul de Figueiredo, Jin-Ming Yang, Jianxun Song
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101333- (2020)
Summary: The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress hepatitis B virus (HBV) infection. After adoptive transfer, PSC-CTLs can infiltrate
Externí odkaz:
https://doaj.org/article/cf0706687d7a46c6996dacfc2eeed9d9