Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jufang Barkalow"'
Autor:
Thaddeus S. Franczyk, Lawrence Kolaczkowski, James C. Marek, Donna K. Montavon, Maureen A. McLaughlin, Guangxin Liang, Anthony R. Haight, Vincent S. Chan, Travis B. Dunn, John E. Hengeveld, David M. Barnes, Jufang Barkalow, Shashank Shekhar, Brian J. Kotecki, James J. Napier
Publikováno v:
The Journal of Organic Chemistry. 84:4873-4892
Dasabuvir (1) is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the course of the development of the synthetic route, two novel coupling reactions were developed
Autor:
Wayne A. Pritts, Anthony R. Haight, Lawrence Kolaczkowski, Jufang Barkalow, David M. Barnes, Adam Schellinger
Publikováno v:
The Journal of organic chemistry. 84(8)
( R)-Boc-2-methylproline (3a) was synthesized in good yield with excellent stereochemical control from alanine benzyl ester hydrochloride 11. The process, which is based on a modification of one described by Kawabata, proceeds in four steps and requi
Autor:
David M. Barnes, Jufang Barkalow, Yong Chen, Francis A. J. Kerdesky, John E. Hengeveld, Anthony R. Haight, Bryan Macri, Ashok K. Gupta, Agnes Pal, Brian J. Kotecki
Publikováno v:
Organic Process Research & Development. 13:225-229
The impact of entropic effects on the classical salt resolution of a 2-arylpyrrolidine is described. We have found that the crystallization of a racemic mixture of the base with tartaric acid led to a salt in which the undesired enantiomer is incorpo
Publikováno v:
Organic Letters. 11:273-275
A novel method for the preparation of MOM-protected carbamates is described that avoids the use of MOM-Cl, a regulated carcinogen. The two-step, one-pot procedure generates a reactive N-chloromethyl carbamate that is quenched with methanol to afford
Autor:
Pulla Reddy Singam, Jufang Barkalow, Gary Callen, b Mukund Chorghade, c and Howard Foote, Michael Cain, a Roger Koops, Richard Pariza d, David Brown, Patel Ketan M, Subhash R. Patel, Ashok K. Gupta, Mahendra N. Deshpande
Publikováno v:
Organic Process Research & Development. 2:351-356
A scalable process for the novel antidepressant ABT-200, starting with 5,6-methylenedioxy-1-tetralone, is described. The new process improves the scale-up and safety concerns associated with the previously employed route to ABT-200. The scalable proc
Publikováno v:
ChemInform. 40
A novel method for the preparation of MOM-protected carbamates is described that avoids the use of MOM-Cl, a regulated carcinogen. The two-step, one-pot procedure generates a reactive N-chloromethyl carbamate that is quenched with methanol to afford
Publikováno v:
Organic Letters; Jan2009, Vol. 11 Issue 2, p273-275, 3p