Development of N-2,4-pyrimidine-N-phenyl-N′-alkyl ureas as orally active inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 2

Autor: Maier, Jennifer A., Brugel, Todd A., Clark, Michael P., Sabat, Mark, Golebiowski, Adam, Bookland, Roger G., Laufersweiler, Matthew J., Laughlin, Steven K., VanRens, John C., De, Biswanath, Hsieh, Lily C., Brown, Kimberly K., Juergens, Karen, Walter, Richard L., Janusz, Michael J.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 1 July 2006 16(13):3514-3518

Development of orally bioavailable bicyclic pyrazolones as inhibitors of tumor necrosis factor-alpha production.

Autor: Clark MP; Health Care Research Center, Procter and Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, Ohio 45040, USA. clark.mp@pg.com, Laughlin SK, Laufersweiler MJ, Bookland RG, Brugel TA, Golebiowski A, Sabat MP, Townes JA, VanRens JC, Djung JF, Natchus MG, De B, Hsieh LC, Xu SC, Walter RL, Mekel MJ, Heitmeyer SA, Brown KK, Juergens K, Taiwo YO, Janusz MJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2004 May 20; Vol. 47 (11), pp. 2724-7.