Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Juergen W. Pfeiffer"'
Autor:
Richard Malcolmson, Andrew P.-Z. Clark, James B Fink, Plamena Entcheva-Dimitrov, Juergen W. Pfeiffer, Dennis Sullivan, Simon Authier, Kim Bujold, Jeffrey S. Tepper
Publikováno v:
International journal of toxicology. 39(5)
Currently, off-label continuous administration of inhaled epoprostenol is used to manage hemodynamics during mitral valve surgery. A toxicology program was developed to support the use of inhaled epoprostenol during mechanical ventilation as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d257de9b3d7c7a73ebba3578c25b239d
https://pubmed.ncbi.nlm.nih.gov/32787636
https://pubmed.ncbi.nlm.nih.gov/32787636
Publikováno v:
Journal of pharmacological and toxicological methods. 99
Introduction For nonclinical drug development, it is optimal if safety pharmacology and toxicology studies are performed in a model that reasonably represents the patient the drug is intended to treat. To simulate prolonged inhalation therapy in vent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234da98a51d6cccec4112375884b4576
https://pubmed.ncbi.nlm.nih.gov/31078712
https://pubmed.ncbi.nlm.nih.gov/31078712
Autor:
Masaki Kajimoto, Michael A. Portman, Coral N. Ringer, Gail H. Deutsch, Jonathan A. Poli, James B Fink, Rajesh Uthamanthil, Juergen W. Pfeiffer, Joseph Zimmerman, Robert M DiBlasi, Patrik Malone, Dolena R. Ledee, David N Crotwell
Publikováno v:
Critical Care Explorations
Critical Care Explorations, Vol 3, Iss 2, p e0338 (2021)
Critical Care Explorations, Vol 3, Iss 2, p e0338 (2021)
Supplemental Digital Content is available in the text.
Objectives: Effective treatment options for surfactant therapy in acute respiratory distress syndrome and coronavirus disease 2019 have not been established. To conduct preclinical studies i
Objectives: Effective treatment options for surfactant therapy in acute respiratory distress syndrome and coronavirus disease 2019 have not been established. To conduct preclinical studies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e5fa5c26ae50758332006ca88af73e
https://doi.org/10.1097/cce.0000000000000338
https://doi.org/10.1097/cce.0000000000000338
Autor:
Stephen K. Doberstein, Phi Quach, Kathleen Gogas, Takahiro Miyazaki, Daniel McWeeney, Irene Y. Choi, Jennifer A. Riggs, David Gauvin, Juli Evans, Cherie F. Ali, Juergen W. Pfeiffer, Jonathan Zalevsky, Werner Rubas, Timothy A. Riley, Neel K. Anand, Hema Gursahani, Marlene Hennessy, Grace Kim
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 363(1)
The increasing availability of prescription opioid analgesics for the treatment of pain has been paralleled by an epidemic of opioid misuse, diversion, and overdose. The development of abuse-deterrent formulations (ADFs) of conventional opioids such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60ec3d5b31fa337024f90b96e69d05a
https://pubmed.ncbi.nlm.nih.gov/28778859
https://pubmed.ncbi.nlm.nih.gov/28778859
Autor:
Matthew B Nodwell, G. Roger Thomas, Edmund J. Moran, Juergen W. Pfeiffer, Martin S. Linsell, Uwe Klein, Cecile Yu, Jacobsen John R, R. Murray McKinnell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2871-2876
A multivalent approach focused on amine-based secondary binding groups was applied to the discovery of long-acting inhaled β2-agonists. Addition of amine moieties to the neutral secondary binding group of an existing β2-agonist series was found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e63611622bf41320ee0b1be430ab4f2
https://doi.org/10.1016/j.bmcl.2014.04.095
https://doi.org/10.1016/j.bmcl.2014.04.095
Autor:
Cecile Yu, Uwe Klein, Eric Fournier, Jesse D. Combs, Jacobsen John R, G. Roger Thomas, Juergen W. Pfeiffer, Edmund J. Moran, Seok-Ki Choi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1213-1218
A multivalent approach was applied to the design of long-acting inhaled β(2)-adrenoceptor agonists. A series of dimeric arylethanolamines based on the short acting β(2)-adrenoceptor agonist albuterol were prepared, varying the nature and length of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e97db1149e913ebc6365df69b1fac0
https://doi.org/10.1016/j.bmcl.2011.11.072
https://doi.org/10.1016/j.bmcl.2011.11.072
Autor:
Timothy J. Church, G. Roger Thomas, Jacobsen John R, Uwe Klein, Edmund J. Moran, Teresa M. Pulido-Rios, James B. Aggen, Cecile Yu, Juergen W. Pfeiffer
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(12)
A series of potent β2-adrenoceptor agonists incorporating a biarylamine secondary binding group was identified. The previously reported milveterol (5), identified by a multivalent approach and containing a typical β2-agonist primary binding group l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a17d43f5c5c5d404c1b478dc1594b8d
https://pubmed.ncbi.nlm.nih.gov/24813741
https://pubmed.ncbi.nlm.nih.gov/24813741
Autor:
Melinda C. Aldrich, Mark W. Moore, Harm HogenEsch, Daniel Tumas, Juergen W. Pfeiffer, Daniel G. Rudmann, Jeffery S. Tepper
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 279:L1047-L1057
Tumor necrosis factor-α (TNF) is implicated as an important proinflammatory cytokine in asthma. We evaluated mice deficient in TNF receptor 1 (TNFR1) and TNFR2 [TNFR(−/−) mice] in a murine model of allergic inflammation and found that TNFR(−/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fd4f9e3d817a169a7f1b3eaf8d36ba
https://doi.org/10.1152/ajplung.2000.279.6.l1047
https://doi.org/10.1152/ajplung.2000.279.6.l1047
Autor:
Juergen W. Pfeiffer, Jennifer Riggs-Sauthier, Hema Gursahani, David Lechuga-Ballesteros, C. Simone Fishburn
Publikováno v:
Journal of pharmaceutical sciences. 98(8)
Polyethylene glycol (PEG) polymers are large amphiphilic molecules that are highly hydrated in solution. To explore the permeability properties of different sized PEG polymers across epithelial membranes in vivo, we examined the absorption of fluores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a16bf488557015c92d8ced214ae130
https://pubmed.ncbi.nlm.nih.gov/19408293
https://pubmed.ncbi.nlm.nih.gov/19408293
Autor:
Jeffrey S. Tepper, J. Rachel Reader, Edward S. Schelegle, Dallas M. Hyde, Lei F. Putney, Juergen W. Pfeiffer, Melinda C. Aldrich
Publikováno v:
The American journal of pathology. 162(6)
Increased mucus production in asthma is an important cause of airflow obstruction during severe exacerbations. To better understand the changes in airway epithelium that lead to increased mucus production, ovalbumin-sensitized and -challenged mice we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca19cbc3fa0fbf9224add80b59b8adc
https://pubmed.ncbi.nlm.nih.gov/12759261
https://pubmed.ncbi.nlm.nih.gov/12759261