Výsledky vyhledávání - "Juergen Stichler"

Catalytic Asymmetric Reduction of a 3,4-Dihydroisoquinoline for the Large-Scale Production of Almorexant: Hydrogenation or Transfer Hydrogenation?

Autor: Juergen Stichler, Peter Kapitan, Laurent Lefort, Richard A. Ward, Thomas Dax, Stefan Abele, Johannes G. de Vries, André H.M. de Vries, Gerard K. M. Verzijl, Wolfgang Skranc, Matthias Helms, Zarghun Nazir, Imboden Christoph

Publikováno v: Organic Process Research & Development. 17:1531-1539

Several methods are presented for the enantioselective synthesis of the tetrahydroisoquinoline core of almorexant (ACT-078573A), a dual orexin receptor antagonist. Initial clinical supplies were secured by the Noyori Ru-catalyzed asymmetric transfer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7972c7aea27eef7454b3f0f79ab4458
https://doi.org/10.1021/op400268f

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