Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Juergen Holtz"'
Autor:
Rolf-Edgar Silber, Simone Kahrstedt, Alexander Navarrete Santos, Jochen Börgermann, Ivar Friedrich, RJ Scheubel, Andreas Simm, Juergen Holtz
Publikováno v:
International Journal of Cardiology. 139:134-141
Background Progenitor cells contribute to repair of ischemia-associated disturbances of microcirculations, but detailed mechanisms of paracrine angiogenic activation of endothelium by progenitor cells are unclear. The present study was designed to te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da8496918cfd626e31e8c346e0c11d4
https://doi.org/10.1016/j.ijcard.2008.10.009
https://doi.org/10.1016/j.ijcard.2008.10.009
Autor:
Ursula Müller-Werdan, Stefan Engelhardt, Susanne Rohrbach, Juergen Holtz, Karl Werdan, Martin J. Lohse
Publikováno v:
Molecular Medicine. 13:605-614
The induction of proinflammatory cytokines in stressed myocardium is considered an innate immune response, but the role of beta-adrenergic signaling in this proinflammatory response and the mechanisms of cardioprotection by beta-blockers are not full
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307d7f463122467f841658e9e850c8db
https://doi.org/10.2119/2007-00071.rohrbach
https://doi.org/10.2119/2007-00071.rohrbach
Publikováno v:
Experimental Gerontology. 41:525-531
Extension of life span by caloric restriction is assumed to result from retardation of a genetically determined program of ageing, but the new concept of hormesis regards caloric restriction as mild stress, which triggers active, protective reactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5d86f271e5f013f563a1a7e0d7620a
https://doi.org/10.1016/j.exger.2006.02.001
https://doi.org/10.1016/j.exger.2006.02.001
Autor:
RJ Scheubel, Ivar Friedrich, Holger Weber, Juergen Holtz, Andreas Simm, Jochen Börgermann, Rolf-Edgar Silber, Simone Kahrstedt
Publikováno v:
Experimental Gerontology. 41:540-548
Diabetes and ageing induce reduction and dysfunction of vascular progenitor cells. Advanced glycation endproducts (AGEs) accumulate in diabetes and ageing. We investigated the influence of AGEs on function of CD34 progenitor cells. CD34 cells were co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78972140d6ba3295f2f2c8a109772b9
https://doi.org/10.1016/j.exger.2006.01.002
https://doi.org/10.1016/j.exger.2006.01.002
Autor:
Ursula Ravens, Peter Ellinghaus, Juergen Holtz, Ulrich Nielsch, Henning Morawietz, Joachim Huetter, Dobromir Dobrev, RJ Scheubel
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 129(6):1383-1390
Objectives The knowledge of chamber-specific gene expression in human atrial and ventricular myocardium is essential for the understanding of myocardial function and the basis for the identification of putative therapeutic targets in the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438042f83d03d15e70c6d50c0e397665
Publikováno v:
Basic Research in Cardiology. 100:240-249
Membrane-bound and secreted neuregulin isoforms induce growth, survival and differentiation by activating erbB tyrosine kinase receptors. In cultured cardiomyocytes, erbB2 and erbB4 receptors regulate apoptosis by controlling bcl-x splicing, and cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86d6bd3a5653aaed7d95371856bc9e8
https://doi.org/10.1007/s00395-005-0514-4
https://doi.org/10.1007/s00395-005-0514-4
Dose-Dependent Regulation of NAD(P)H Oxidase Expression by Angiotensin II in Human Endothelial Cells
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 22:1845-1851
Objective— Angiotensin II (Ang II)–mediated induction of vascular superoxide anion formation could contribute to the development of endothelial dysfunction, hypertension, and atherosclerosis. An NAD(P)H oxidase has been identified as a major endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eafea617f1fc5f2fd0391fc81f2fc7d
https://doi.org/10.1161/01.atv.0000035392.38687.65
https://doi.org/10.1161/01.atv.0000035392.38687.65
Autor:
Andreas Simm, Juergen Holtz, Rolf Edgar Silber, RJ Scheubel, Kostas Drogaris, Dorothea Darmer, Babett Bartling
Publikováno v:
Journal of the American College of Cardiology. 39(3):481-488
Objectives Activation of the caspase cascade through the mitochondrial and/or death receptor pathway was investigated in the failing human myocardium, in which the mode and extent of the cascade activation are unknown. Background In terminal heart fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58018243c288b82f9d376a9f2821abd
Autor:
Paul M.L. Janssen, Juergen Holtz, Dorothea Darmer, Heike Schumann, Gerd Hasenfuss, J. Prestle, Stephan E. Lehnart, Oliver Zeitz
Publikováno v:
Scopus-Elsevier
10.1152/ajpheart.00024.2001.—Increased mechanical load has been proposed as an inductor of apoptosis, but it is unknown whether this can occur in the range of pre- and afterloads that prevail in the beating heart. We investigated apoptosis in cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae097c76fc0d88a34f4506681506701d
https://doi.org/10.1152/ajpheart.00024.2001
https://doi.org/10.1152/ajpheart.00024.2001
Autor:
Juergen Holtz, Henning Morawietz, Tatsuya Sawamura, Bernd Niemann, Nicole Duerrschmidt, Jan Galle
Publikováno v:
Biochemical and Biophysical Research Communications. 284:961-965
In this study, we analyzed the effect of endothelin-1 (ET-1) on expression of the lectin-like oxidized low-density lipoprotein (oxLDL) receptor-1 LOX-1 and on oxLDL uptake in primary cultures of human umbilical vein endothelial cells (HUVEC). LOX-1 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffe446de4c3522239575d8af406a2e7
https://doi.org/10.1006/bbrc.2001.5044
https://doi.org/10.1006/bbrc.2001.5044