Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Juergen H. Bertram"'
Publikováno v:
Clinical Immunotherapeutics. 6:211-227
Protein A is a staphylococcal bacterial cell wall component that binds certain subclasses of IgG, other classes of mammalian immunoglobulins and immune complexes. Initial studies in tumour-bearing animals and in patients with cancer were based on the
Autor:
Sharon K. Cochran, Arsinur Oral, Stefan Korec, Snyder Hw, Troy H. Guthrie, Reneé L. Peugeot, William Perkins, Juergen H. Bertram, A. Mittelman, Joseph P. Balint, David H. Henry, David Ciavarella, Gerald L. Messerschmidt, Frank R. Jones, David Wuest
Publikováno v:
Cancer. 71:1882-1892
Background. Chemotherapy-associated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (C-TTP/HUS) is a condition involving thrombocytopenia, microangiopathic hemolytic anemia, and progressive renal dysfunction that develops in 2–10% of
Autor:
Juergen H. Bertram, Sharon K. Cochran, Troy H. Guthrie, Frank R. Jones, Harry W. Snyder, Joseph P. Balint, Abraham Mittelman
Publikováno v:
Blood. 79:2237-2245
Extracorporeal immunoadsorption of plasma to remove IgG and circulating immune complexes (CIC) was evaluated as a therapy for adults with treatment-resistant immune thrombocytopenic purpura (ITP). Seventy-two patients with initial platelet counts les
Autor:
Harry W. Snyder, Juergen H. Bertram, David H. Henry, Dobri D. Kiprov, W. Barrett Benny, Abraham Mittelman, Gerald L Messerschmidt, Sharon K. Cochran, William Perkins, Joseph P. Balint, Frank R. Jones
Publikováno v:
AIDS (London, England). 5(10)
Thirty-seven HIV-infected homosexual men with thrombocytopenia (less than 100 x 10(9)/l) received protein A immunoadsorption treatments to remove platelet-sensitizing immunoglobulin (Ig) G and circulating immune complexes (CIC) from plasma. Patients
Publikováno v:
Cancer Drug Delivery. 4:47-53
Although cisplatin may have intrinsic activity against astrocytoma, limited penetration into the central nervous system may severely curtail delivery of adequate amounts of drug to the tumor. In an attempt to increase the dose of delivered drug witho
Publikováno v:
Artificial Organs. 13:71-77
Platelet-directed antibodies and circulating immune complexes (CIC) were removed from plasma of patients with human immunodeficiency virus (HIV) infection and idiopathic thrombocytopenic purpura (ITP) by extracorporeal immunoadsorption using columns
Autor:
Juergen H. Bertram, David S. Terman
Publikováno v:
European Journal of Cancer and Clinical Oncology. 21:1115-1122
INTRODUCTION IMMOBILIZED protein A (SPA) has been used as experimental cancer therapy in animal models and in man. Striking antitumor responses were frequently observed and prompted an intensive search for the active bioreactants and the mechanism of
Autor:
Donella Jenkins, David H. Henry, Juergen H. Bertram, Dobri D. Kiprov, Snyder Hw, Ira A. Shulman, Parkash S. Gill
Publikováno v:
Artificial Organs. 12:484-490
Nine homosexual patients with immune thrombocytopenia were treated with autologous plasma that had been perfused over silica-immobilized Staphylococcus aureus protein A (SpA). Pretreatment platelet counts ranged from 10,000 to 98,000 cells/mm3 (mean:
Autor:
Daisy Boquiren, Paul R. Meyer, Florence M. Hoffman, Parkash S. Gill, Malcolm S. Mitchell, Alexandra M. Levine, Juergen H. Bertram
Publikováno v:
Blood. 68:752-761
Eight patients with cutaneous T cell lymphomas (CTCL) and five with various other T cell malignancies were treated with mouse monoclonal antibody (MoAb) T101. Doses of 1 to 500 mg were administered weekly over a two-hour period and resulted in one co
Autor:
David H. Henry, M V Viola, Snyder Hw, Ainsworth S, Fiore J, Juergen H. Bertram, A. Mittelman, Gerald L. Messerschmidt, Edward P. Ambinder, J Louie
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 6(2)
Circulating immune complexes (CIC) are known to be present in cancer patients and are responsible for much of the cancer-associated immunosuppression. Removal or modulation of these "blocking factors" can reverse the immunosuppression. Protein A from