4-Pyridoxic Acid/Pyridoxine Ratio in Patients with Type 2 Diabetes is Related to Global Cardiovascular Risk Scores

Autor: Rima Obeid, Juergen Geisel, Wilfred A. Nix

Publikováno v: Diagnostics, Vol 9, Iss 1, p 28 (2019)

Background: Vascular diseases are multifactorial and several risk factors may have synergetic effect on the global vascular risk. Among patients with diabetes, we investigated whether vitamin B6 species differ according to global cardiovascular risk.

Externí odkaz: https://doaj.org/article/fed504ce72e54025bbfbe4083f91ab01

The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics

Autor: Per Magne Ueland, Hussain M. Awwad, Giulia Treccani, Sandra Tillmann, Chad W. MacPherson, Denise F. Happ, Thomas A. Tompkins, Gregers Wegener, Rima Obeid, Juergen Geisel

Publikováno v: Tillmann, S, Awwad, H M, MacPherson, C W, Happ, D F, Treccani, G, Geisel, J, Tompkins, T A, Ueland, P M, Wegener, G & Obeid, R 2021, ' The kynurenine pathway is upregulated by methyl-deficient diet and changes are averted by probiotics ', Molecular Nutrition & Food Research, vol. 65, no. 9, 2100078, pp. e2100078 . https://doi.org/10.1002/mnfr.202100078
Molecular Nutrition & Food Research

Scope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway. This study used Sprague Dawley rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6901d8260975ae41e28ff7bd8b3216

Determinants of soluble angiotensin-converting enzyme 2 concentrations in adult patients with complex congenital heart disease

Autor: Rima Obeid, Juergen Geisel, Hashim Abdul-Khaliq, Stefan Wagenpfeil, Sarah Wissing, Nils Mackenstein, Tanja Raedle-Hurst

Publikováno v: Clinical Research in Cardiology

Background Angiotensin-converting enzyme (ACE) 2 is known to be a functional receptor for SARS-CoV-2 in the current pandemic. Soluble ACE2 (sACE2) concentrations are elevated in patients with various cardiovascular disorders including heart failure.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f0427d214fa3f488ae04ce6b5c13dc
https://pubmed.ncbi.nlm.nih.gov/33280062

Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism

Autor: Juergen Geisel, Stefan Graeber, Yannick Rabagny, Rima Obeid, Hussain M. Awwad, Wolfgang Herrmann

Publikováno v: Obeid, R, Awwad, H M, Rabagny, Y, Graeber, S, Herrmann, W & Geisel, J 2016, ' Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism ', The American Journal of Clinical Nutrition, vol. 103, no. 3, pp. 703-11 . https://doi.org/10.3945/ajcn.115.121269

BACKGROUND: Elevated plasma concentrations of the gut bacteria choline metabolite trimethylamine N-oxide (TMAO) are associated with atherosclerosis. However, the determinants of TMAO in humans require additional assessment.OBJECTIVE: We examined card

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f6228e7a86f4648cd161d0eaf41df1
https://doi.org/10.3945/ajcn.115.121269

Measurement of concentrations of whole blood levels of choline, betaine, and dimethylglycine and their relations to plasma levels

Autor: Rima Obeid, Hussain M. Awwad, Juergen Geisel, Susanne H. Kirsch

Publikováno v: Journal of Chromatography B. 957:41-45

We aimed at developing a method for the measurement of choline and its metabolites in whole blood (WB). After an extraction step, quantification of choline, betaine, and dimethylglycine (DMG) was performed using ultra performance liquid chromatograph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92830e8a29058fa62e82e52901b5cd8d
https://doi.org/10.1016/j.jchromb.2014.02.030