Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Juergen Bockmann"'
Autor:
Ekaterina Atanasova, Andrea Pérez Arévalo, Ines Graf, Rong Zhang, Juergen Bockmann, Anne-Kathrin Lutz, Tobias M. Boeckers
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Autism spectrum disorder (ASD) is mainly characterized by deficits in social interaction and communication and repetitive behaviors. Known causes of ASD are mutations of certain risk genes like the postsynaptic protein SHANK3 and
Externí odkaz:
https://doaj.org/article/508bd4040ef242d8bc937e9009dc09be
Autor:
Sarah Jesse, Hans‐Peter Müller, Michael Schoen, Harun Asoglu, Juergen Bockmann, Hans‐Juergen Huppertz, Volker Rasche, Albert C. Ludolph, Tobias M. Boeckers, Jan Kassubek
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 1, Pp 46-58 (2020)
Abstract Objective Heterozygous SHANK3 mutations or partial deletions of the long arm of chromosome 22, also known as Phelan–McDermid syndrome, result in a syndromic form of the autism spectrum as well as in global developmental delay, intellectual
Externí odkaz:
https://doaj.org/article/87eb5db2bd2045e083b594b2fcc12b32
Autor:
Carolina Urrutia-Ruiz, Daniel Rombach, Silvia Cursano, Susanne Gerlach-Arbeiter, Michael Schoen, Juergen Bockmann, Maria Demestre, Tobias M. Boeckers
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6081 (2022)
Autism spectrum disorders (ASDs) are characterized by repetitive behaviors and impairments of sociability and communication. About 1% of ASD cases are caused by mutations of SHANK3, a major scaffolding protein of the postsynaptic density. We studied
Externí odkaz:
https://doaj.org/article/956c0cd65eb54b108ced521da9ddaf76
Autor:
Michael Schoen, Harun Asoglu, Helen F. Bauer, Hans-Peter Müller, Alireza Abaei, Ann Katrin Sauer, Rong Zhang, Tian-jia Song, Juergen Bockmann, Jan Kassubek, Volker Rasche, Andreas M. Grabrucker, Tobias M. Boeckers
Publikováno v:
Frontiers in Neural Circuits, Vol 13 (2019)
Research efforts over the past decades have unraveled both genetic and environmental factors, which contribute to the development of autism spectrum disorders (ASD). It is, to date, largely unknown how different underlying causes result in a common p
Externí odkaz:
https://doaj.org/article/13d027f67c1f4822bf6240febe20bbc1
Autor:
Ann Katrin Sauer, Juergen Bockmann, Konrad Steinestel, Tobias M. Boeckers, Andreas M. Grabrucker
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2134 (2019)
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by deficits in social interaction and communication, and repetitive behaviors. In addition, co-morbidities such as gastro-intestinal problems have frequently be
Externí odkaz:
https://doaj.org/article/50ef25c828324926902d8357d7ee0c13
Autor:
Stefan Liebau, Julie Steinestel, Leonhard Linta, Alexander Kleger, Alexander Storch, Michael Schoen, Konrad Steinestel, Christian Proepper, Juergen Bockmann, Michael J Schmeisser, Tobias M Boeckers
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18148 (2011)
BackgroundThe stabilization or regulated reorganization of the actin cytoskeleton is essential for cellular structure and function. Recently, we could show that the activation of the SK3-channel that represents the predominant SK-channel in neural st
Externí odkaz:
https://doaj.org/article/0e0ea8c5a24d4b38b35ba8be100c8676
Autor:
Christian Proepper, Konrad Steinestel, Michael J Schmeisser, Jutta Heinrich, Julie Steinestel, Juergen Bockmann, Stefan Liebau, Tobias M Boeckers
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27045 (2011)
BACKGROUND: Abelson-interacting protein 1 (Abi-1) plays an important role for dendritic branching and synapse formation in the central nervous system. It is localized at the postsynaptic density (PSD) and rapidly translocates to the nucleus upon syna
Externí odkaz:
https://doaj.org/article/8f45e73726fe4835acf2ea593895ab9d
Autor:
null Mubashir Ahmad, null Nadine Stirmlinger, null Irfana Jan, null Ulrich Stifel, null Sooyeon Lee, null Marcel Weingandt, null Ulrike Kelp, null Juergen Bockmann, null Anita Ignatius, null Tobias M Boeckers, null Jan Tuckermann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52d6fce1072bf3aa099aa16f0500b732
https://doi.org/10.1002/jbm4.10711/v3/response1
https://doi.org/10.1002/jbm4.10711/v3/response1
Autor:
Débora Garrido, Stefania Beretta, Stefanie Grabrucker, Helen Friedericke Bauer, David Bayer, Carlo Sala, Chiara Verpelli, Francesco Roselli, Juergen Bockmann, Christian Proepper, Alberto Catanese, Tobias M. Boeckers
Publikováno v:
Molecular psychiatry 27(12), 4994-5006 (2022). doi:10.1038/s41380-022-01756-8
Members of the Shank protein family are master scaffolds of the postsynaptic architecture and mutations within the SHANK genes are causally associated with autism spectrum disorders (ASDs). We generated a Shank2-Shank3 double knockout mouse that is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdd439bd2ea247f1ff0ca2a0e2c6dcb
https://pub.dzne.de/record/165245
https://pub.dzne.de/record/165245
Autor:
Kevin Thome, Carolina Urrutia-Ruiz, Stefanie Grabrucker, Carlo Sala, Günter Ehret, Johanna Schweizer, Andreas M. Grabrucker, Tobias M. Boeckers, Michael Schön, Rong Zhang, Juergen Bockmann, Bastian Hengerer, Jessica Pagano, Chiara Verpelli
Publikováno v:
The EMBO journal 40(5), e104267 (2021). doi:10.15252/embj.2019104267
The EMBO Journal
The EMBO Journal
Impairments in social relationships and awareness are features observed in autism spectrum disorders (ASDs). However, the underlying mechanisms remain poorly understood. Shank2 is a high���confidence ASD candidate gene and localizes primarily t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a338e9ab894eff16eec4c405d9ab335c