Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Juerg Hunziker"'
Autor:
Eric Weber, Juerg Hunziker, Dominic Hoepfner, Ralph Riedl, Vivian Prindle, Sven Schuierer, Yue Fu, Silvio Roggo, Florian Fuchs, Ashraf S. Ibrahim, Jianshi Tao, Frank Petersen, Manuel Mihalic, David Estoppey, Dominik Pistorius, Christian Studer, Etienne Richard, Klaus Memmert, Thomas Aust, Frederic Grandjean
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature communications, vol 11, iss 1
Nature communications, vol 11, iss 1
Biosynthesis of glycosylphosphatidylinositol (GPI) is required for anchoring proteins to the plasma membrane, and is essential for the integrity of the fungal cell wall. Here, we use a reporter gene-based screen in Saccharomyces cerevisiae for the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390861add4674d3014656f11c8eddcee
https://doaj.org/article/f7cd22501a204070a70510bf4ba6dfe2
https://doaj.org/article/f7cd22501a204070a70510bf4ba6dfe2
Publikováno v:
Computational Geosciences, vol. 24, no. 3, pp. 1101-1120
Relating the attenuation and velocity dispersion of seismic waves to fluid pressure diffusion (FDP) by means of numerical simulations is essential for constraining the mechanical and hydraulic properties of heterogeneous porous rocks. This, in turn,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03688d23f653aec70c6451ac9c788b0
https://doi.org/10.1007/s10596-019-09928-2
https://doi.org/10.1007/s10596-019-09928-2
Autor:
Bertrand Arnaud, Marianne Uteng, Sandra Holzinger, Peter von Matt, Patrik Roethlisberger, Ivan Galimberti, Christel Guibourdenche, Felix Freuler, Simon Haenni, Markus Kaufmann, Murielle Brichet, Amanda Cobos-Correa, Christian Bergsdorf, Mario Bernhard, Andreas Lerchner, Juerg Hunziker, Valery Polyakov, Joerg Kallen, Aude Izaac, Hans-Joerg Martus, Azeddine Elhajouji, Lukas Leder, Guglielmo Roma, Nikolaus Stiefl
Publikováno v:
ChemMedChem. 13(18)
CLK2 inhibition has been proposed as a potential mechanism to improve autism and neuronal functions in Phelan-McDermid syndrome (PMDS). Herein, the discovery of a very potent indazole CLK inhibitor series and the CLK2 X-ray structure of the most pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e987aac713b4f86e61928a58cc93de51
https://pubmed.ncbi.nlm.nih.gov/29985556
https://pubmed.ncbi.nlm.nih.gov/29985556
Publikováno v:
Chem. 1:336-338
Juerg Hunziker earned a PhD from ETH Zurich, followed by a postdoctoral stay at Caltech and a junior group-leader position (University of Bern), before joining Novartis, where he is currently responsible for natural-product chemistry in Global Discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d98c14d97b108f93b634fef7e452848
https://doi.org/10.1016/j.chempr.2016.08.018
https://doi.org/10.1016/j.chempr.2016.08.018
Autor:
Francois Natt, Thomas Faller, Joel Krauser, Esther van de Kerkhof, Juerg Hunziker, Karine Litherland, Jesper Christensen, Piet Swart
Publikováno v:
Drug Metabolism and Disposition. 41:1211-1219
Absorption, distribution, metabolism, and excretion properties of two unformulated model short interfering RNA (siRNAs) were determined using a single internal [(3)H]-radiolabeling procedure, in which the full-length oligonucleotides were radiolabele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f517889d1de3a0a0211682de90694ec
https://doi.org/10.1124/dmd.112.050666
https://doi.org/10.1124/dmd.112.050666
Publikováno v:
Gene Therapy. 13:496-502
MicroRNAs (miRNAs) are endogenous 19-25 nucleotide RNAs that have recently emerged as a novel class of important gene-regulatory molecules involved in many critical developmental and cellular functions. miRNAs have been implicated in the pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beccfdce2ebc17694b0c17cba1792d03
https://doi.org/10.1038/sj.gt.3302654
https://doi.org/10.1038/sj.gt.3302654
Autor:
Michael Beverly, Armin Beyerbach, Karine Litherland, David Morrissey, Julien A. Boos, Mari-Luz Piccolotto, Piet Swart, Juerg Hunziker, Andre Dattler, Werner Zuercher, Thomas Faller, Sandro Gfeller, David W. Kirk, Iwan Beuvink, Fabian Von Arx, Esther van de Kerkhof, Jesper Christensen, Philippe Neuner, William Leonard Wishart
Publikováno v:
Nucleic Acids Research
Efficient tissue-specific delivery is a crucial factor in the successful development of therapeutic oligonucleotides. Screening for novel delivery methods with unique tissue-homing properties requires a rapid, sensitive, flexible and unbiased techniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fbeae90599d659168cb139bc7414fc
https://doi.org/10.1093/nar/gkt515
https://doi.org/10.1093/nar/gkt515
Pyrimidine oligodeoxyribonucleotides bind in the major groove of DNA parallel to the purine Watson-Crick strand by formation of specific hydrogen bonds between thymine and adenine (T•AT triplet) and protonated cytosine and guanine (C+GC triplet) on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741248ace03f22c33f7db8b5d1a1018c
https://resolver.caltech.edu/CaltechAUTHORS:20160510-105204315
https://resolver.caltech.edu/CaltechAUTHORS:20160510-105204315
