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of 6
pro vyhledávání: '"Juerg F. Tschopp"'
Autor:
C. Mazur, Robert Fitridge, Michael D. Pierschbacher, B. R. Copeland, Takeo Abumiya, G. J. Del Zoppo, Juerg F. Tschopp, James A. Koziol
Publikováno v:
Stroke. 31:1402-1410
Background and Purpose —Platelets become activated and accumulate in brain microvessels of the ischemic microvascular bed after experimental focal cerebral ischemia. The binding of glycoprotein IIb/IIIa (integrin α IIb β 3 ) on platelets to fibri
Autor:
Juerg F. Tschopp, John R. Harper, Michael D. Pierschbacher, Nancy J. Sipes, William S. Craig, James W. Polarek
Publikováno v:
Journal of Cellular Biochemistry. 56:150-154
Manipulation of the wound healing process and the manner in which tissues interact with inert biomaterials were both made possible with the discovery of arginine-glycine-aspartic (RGD) acid as a major cell recognition signal in the extracellular matr
Autor:
Michael D. Pierschbacher, Juerg F. Tschopp, Soan Cheng, Daniel G. Mullen, Doug Dixon, William S. Craig
Publikováno v:
Journal of Medicinal Chemistry. 37:1-8
Utilizing conformational constraints in conjunction with various structural considerations, we have synthesized a series of cyclic disulfide peptides that are highly potent and selective antagonists for the platelet integrin alpha IIb beta 3 (GPIIb/I
Publikováno v:
Thrombosis and Haemostasis. 72:119-124
SummaryMembrane glycoprotein αIIbβ3 on platelets plays a pivotal role in hemostasis by mediating RGD-(arginine-glycine-aspartic acid)-dependent platelet adhesion and aggregation. Antagonists of αIIbβ3 ligand binding function, such as antibodies,
Autor:
Edward M. Driscoll, Shawn C. Black, Dun-Xue Mu, Michael D. Pierschbacher, Juerg F. Tschopp, Benedict R. Lucchesi
Publikováno v:
Coronary artery disease. 4(9)
BACKGROUND A synthetic RGD-containing cyclic peptide, TP9201, specific for the platelet alpha IIb beta 3 receptor complex, was tested for its ability to accelerate thrombolysis and prevent reocclusion in experimentally induced coronary artery thrombo
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