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Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Autor:
Jue Xiang Wang, Mark W. Irvine, Erica S. Burnell, Kiran Sapkota, Robert J. Thatcher, Minjun Li, Noriko Simorowski, Arturas Volianskis, Graham L. Collingridge, Daniel T. Monaghan, David E. Jane, Hiro Furukawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold s
Externí odkaz:
https://doaj.org/article/9cf4ff26eb1b4740b5b19c5f54918691
Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Autor:
Minjun Li, David E. Jane, Graham L. Collingridge, Erica S. Burnell, Robert J. Thatcher, Kiran Sapkota, Arturas Volianskis, Daniel T. Monaghan, Noriko Simorowski, Hiro Furukawa, Mark W. Irvine, Jue Xiang Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Wang, J X, Irvine, M W, Burnell, E S, Sapkota, K, Thatcher, R J, Li, M, Simorowski, N, Volianskis, A, Collingridge, G L, Monaghan, D T, Jane, D E & Furukawa, H 2020, ' Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors ', Nature Communications, vol. 11, no. 1, 423 . https://doi.org/10.1038/s41467-020-14321-0
Nature Communications
Wang, J X, Irvine, M W, Burnell, E S, Sapkota, K, Thatcher, R J, Li, M, Simorowski, N, Volianskis, A, Collingridge, G L, Monaghan, D T, Jane, D E & Furukawa, H 2020, ' Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors ', Nature Communications, vol. 11, no. 1, 423 . https://doi.org/10.1038/s41467-020-14321-0
Nature Communications
N-Methyl-D-aspartate receptors (NMDARs) play critical roles in the central nervous system. Their heterotetrameric composition generates subtypes with distinct functional properties and spatio-temporal distribution in the brain, raising the possibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88f84ba3487ef9967bcf8d4394ee1ae
Autor:
Jue Xiang Wang, Hiro Furukawa
Publikováno v:
Current opinion in structural biology. 54
N-Methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels, which are critically involved in brain development, learning and memory, cognition, as well as a number of neurological diseases and disorders. Structural biology of NMDARs has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7af98b5b8417f9879a888d25bf3104
https://pubmed.ncbi.nlm.nih.gov/30703613
https://pubmed.ncbi.nlm.nih.gov/30703613